Fibromiyaljili Hastalarda D Vitamin Düzeylerinin Değerlendirilmesi ve Fonksiyonel Durum ile İlişkisi

Abstract

Aim: Fibromyalgia syndrome is a common musculoskeletal disorder, characterized by chronic
 widespread pain, multiple tender points, joint stiffness, and systemic symptoms without any underlying
 organic disease. The initial aim of the present study was to determine the vitamin D levels in patients
 with fibromyalgia and compare these values to those found in healthy subjects. Then, correlations
 between functional status, clinical severity of the disease, and vitamin D levels were assessed.
 Material and Methods: This case-control study included 137 female fibromyalgia patients and 109
 healthy female counterparts. The severity of pain was assessed by a visual analogue scale and the
 functional impact was evaluated through the Fibromyalgia Impact Questionnaire in the patient group.
 Vitamin D levels were compared between groups, and the correlation between vitamin D levels and
 questionnaire scores was determined.
 Results: Vitamin D and parathormone levels did not differ significantly between groups (p=0.858,
 p=0.790 respectively). The mean Fibromyalgia Impact Questionnaire scores and the medians for the
 visual analogue scale did not differ significantly among vitamin D deficient, insufficient, and sufficient
 patients (p=0.548 , p=0.952 respectively). In addition, no significant correlation between vitamin D
 levels and the Fibromyalgia Impact Questionnaire score was found(Spearman’s rho=0.056, p=0.513).
 Conclusion: This study did not show any significant differences between the vitamin D levels of
 fibromyalgia patients and those of healthy subjects. Further, in fibromyalgia patients, there was no
 correlation between vitamin D levels and functional status or disease severity

The effect of vitamin D treatment on quality of life in patients with fibromyalgia

“…In the study by Aktunç et al, vitamin D levels were evaluated in patients diagnosed with FMS and a healthy group. While the deficiency and insufficiency rate of vitamin D in the patient group was 80%, this rate was 85% in the healthy group, and it was not found to be statistically significant [10]. Similarly, in the study conducted by Doğru et al, fibromyalgia and healthy groups were examined, and vitamin D deficiency and insufficiency were detected in 60% of the patients and 50.7% of the control group [17].…”

“…Fibromyalgia is one of the commonly observed chronic pain syndromes in society, significantly impacting the quality of life of patients. The prevalence of Vitamin D deficiency in FM patients, relationship with symptom severity, and its effect on daily life have been frequently investigated in the literature, yielding conflicting results [10]. Vitamin D is considered essential for the human body, and its deficiency has been associated with chronic widespread pain syndromes, cardiovascular pathologies, autoimmune diseases, and certain types of cancer [16].…”

“…Its deficiency negatively affects calcium and phosphorus metabolism, osteoblastic cell activity, and bone mineral density [9]. Vitamin D deficiency has been associated with various pathologies such as chronic pain, delayed growth and development in children, malignancy, and autoimmune diseases [10]. It leads to symptoms like widespread chronic pain and fatigue, often coinciding with fibromyalgia syndrome (FMS).…”