Fibromuscular Hamartoma of the Esophagus in an Infant

Beckerman, Robert C.; Taussig, Lynn M.; Froede, Richard C.; Coulthard, Stanley W.; Firor, Hugh V.; Tonkin, Ina L.D.

doi:10.1001/archpedi.1980.02130140027008

Cited by 7 publications

(5 citation statements)

References 5 publications

(1 reference statement)

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“…To the best of our knowledge, twenty studies with twenty esophageal hamartoma cases (1,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) have been reported and eight of these studies described (4,6,8,10,11) were cervical or upper esophagus hamartomas [Halfhide et al (10) and Ginai et al (11) reported the same case], and five cases (5,7,9,13) were in distal or lower esophagus [one (9) was in Chinese, Table 1]. Several other studies (23-32) also reported congenital esophageal stenosis caused by tracheobronchial remnants.…”

Section: Discussionmentioning

confidence: 99%

“…Esophageal chondromatous hamartomas, which are histologically composed of nodules of proliferating hyaline cartilage and spindle cells, are very rare (3). Only several studies have reported that esophageal hamartomas were chondromatous or contained cartilaginous (4)(5)(6)(7)(8)(9) or bony tissue (10,11). We herein present a very rare case of an elderly women with a chondromatous hamartoma in the cervical esophagus.…”

Section: Introductionmentioning

confidence: 95%

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Chondromatous hamartoma of cervical esophagus: a case report and literature review

Zhang

Wang

et al. 2017

J. Thorac. Dis.

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Esophageal chondromatous hamartomas are very rare tumors, characterized by proliferating hyaline cartilage cells. We described the case of a 64-year-old woman, with a progressive foreign body sensation in the laryngopharynx caused by an intraluminal pedicled mass. Transcervical esophagectomy was performed and intraoperative biopsy revealed the mass was a cervical esophageal chondromatous hamartoma.The patient's postoperative course was uneventful and she recovered well. A review of the literature was conducted, and the symptoms, locations, histopathology findings, treatment methods and follow up results of esophageal hamartoma cases were summarized. We found that pre-operative endoscopic ultrasonographyguided fine-needle aspiration (EUS-FNA) can aid in diagnosis and that aggressive surgical treatment should be recommended for cervical esophageal hamartomas.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Chondromatous hamartoma of cervical esophagus: a case report and literature review

Zhang

Wang

et al. 2017

J. Thorac. Dis.

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“…However, in a tumor-like lesion due to fibromuscular tissues, segmental resection of the oesophagus may be recommended as the treatment of choice (11,12). Although surgical iqterventions other than Clark-Adams' procedure were used with favourable results (Table IV), their efTeetiveness remains unclear due to lack of experience and the short term ofthe follow-up.…”

Section: Discussionmentioning

confidence: 99%

Congenital Oesophageal Stenosis due to Fibromuscular Thickening

Todani¹,

Watanabe²,

Mizuguchi³

et al. 1984

Eur J Pediatr Surg

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Three patients with fibromuscular oesophageal stenosis are reported. The onset was usually before 6 months of age; earlier than that of stenosis due to tracheobronchial remnants. The localization of the stenotic area varied from the distal to the mid-oesophagus. Extramucosal myotomy seemed to be the treatment of choice for this lesion, particularly in the mid-oesophagus involved diffusely, because of its good effectiveness, less invasiveness, and simplicity.

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“…Macrophages associated with tumors represent a regulatory bridge between cancer and the immune system of patients. Studies have shown that macrophages and genes that stimulate macrophages worsen the prognosis and condition of patients [ 19 , 20 ]. Other studies suggest that macrophages are involved in the killing of immune cells and influence the effectiveness of different treatment strategies for cancers [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of macrophage related gene in colorectal cancer patients and their functional roles

et al. 2021

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Background Recent scientific research has enabled the identification of macrophages related-genes (MaRG), which play a key role in the control of the immune microenvironment in many human cancers. However, the functional role of MaRGs in human tumors is ill-defined. Herein, we aimed at bioinformatically exploring the molecular signatures of MaRGs in colorectal cancer. Methods A list of MaRGs was generated and their differential expression was analyzed across multiple datasets downloaded from the publicly available functional genomics database Gene Expression Omnibus. The weighted gene co-expression network analysis (WGCNA) was also applied to identify the partner genes of these MaRGs in colorectal cancer. Results After integration of the results from analyses of different datasets, we found that 29 differentially expressed MaRGs (DE-MaRGs) could be considered as CRC-related genes as obtained from the WGCNA analysis. These genes were functionally involved in positive regulation of DNA biosynthetic process and glutathione metabolism. Protein–protein interaction network analysis indicated that PDIA6, PSMA1, PRC1, RRM2, HSP90AB1, CDK4, MCM7, RFC4, and CCT5 were the hub MaRGs. The LASSO approach was used for validating the 29 MaRGs in TCGA-COAD and TCGA-READ data and the results showed that ten among the 29 genes could be considered as MaRGs significantly involved in CRC. The maftools analysis showed that MaRGs were mutated at varying degrees. The nomogram analysis indicated the correlation of these MaRGs with diverse clinical features of CRC patients. Conclusions Conclusively, the present disclosed a signature of MaRGs as potential key regulators involved in CRC pathogenesis and progression. These findings contribute not only to the understanding of the molecular mechanism of CRC pathogenesis but also to the development of adequate immunotherapies for CRC patients.

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Fibromuscular Hamartoma of the Esophagus in an Infant

Cited by 7 publications

References 5 publications

Chondromatous hamartoma of cervical esophagus: a case report and literature review

Chondromatous hamartoma of cervical esophagus: a case report and literature review

Congenital Oesophageal Stenosis due to Fibromuscular Thickening

Identification of macrophage related gene in colorectal cancer patients and their functional roles

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