Fibromyalgia in women

Mountz, James M.; Bradley, Laurence A.; Modell, Jack G.; Alexander, Robert W.; Triana‐Alexander, Mireya; Aaron, Leslie A.; Stewart, Katharine E.; Alarcón, Graciela S.; Mountz, John D.

doi:10.1002/art.1780380708

Cited by 338 publications

(45 citation statements)

References 64 publications

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“…Mountz et al 14 demonstrated significantly reduced rCBF in the bilateral thalami and caudate nuclei in 10 patients with FM, whereas Kwiatek et al 13 only found reduced rBCF in the right thalamus in 17 subjects with FM. Although we did find slightly lower rCBF values in the bilateral thalami and bilateral caudate nuclei in subjects with FM compared with healthy controls, these differences were not significant.…”

Section: Discussionmentioning

confidence: 98%

“…4-6 Functional neuroimaging modalities have been used to demonstrate changes in neuronal activity or blood flow in regions implicated in pain processing between patients with FM and controls. 7,10,11,13,14 MR spectroscopy studies have also described metabolic changes in patients with FM. 23,27 However, to our knowledge, no previous studies have used perfusion MR imaging techniques to investigate perfusion alterations in FM.…”

Section: Discussionmentioning

confidence: 99%

“…The locations of these regions of interest were chosen a priori because of their known involvement in pain transmission or because they had shown abnormalities in previous neuroimaging studies of pain. 13,14,23,26-28 …”

Section: Methodsmentioning

confidence: 99%

“…Kwiatek et al 13 showed decreased rCBF in the inferior dorsal pons and the right thalamus in patients with FM versus healthy controls. A study by Mountz et al 14 demonstrated decreased baseline rCBF in the bilateral thalami and caudate nuclei in patients with FM compared with healthy controls by using SPECT. SPECT imaging has demonstrated increases in rCBF in the bilateral thalami and basal ganglia of 14 subjects with FM following treatment with amitriptyline, suggesting that reductions in rCBF in FM normalize with clinical improvement.…”

mentioning

confidence: 99%

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Cerebral Blood Flow Alterations in Pain-Processing Regions of Patients with Fibromyalgia Using Perfusion MR Imaging

Foerster¹,

Petrou²,

Harris³

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE Widespread pain sensitivity in patients with FM suggests a CNS processing problem. The purpose of this study was to assess alterations in perfusion as measured by DSC in a number of brain regions implicated in pain processing between patients with FM and healthy controls. MATERIALS AND METHODS Twenty-one patients with FM and 27 healthy controls underwent conventional MR imaging and DSC. For DSC, 12 regions of interest were placed in brain regions previously implicated in pain processing. rCBF values were calculated for each region of interest. Subjects answered mood/pain coping questionnaires and underwent clinical/experimental pain assessment. RESULTS There were significant correlations between the thalamic rCBF values and the pain-control beliefs of FM subjects. The strength of the relationship between clinical pain measures and thalamic rCBF values increased after adjusting for pain-control beliefs. There was a significantly different distribution pattern of rCBF values across various brain regions between the FM group and the healthy controls. There was a lower degree of correlation in the FM group between the thalamic rCBF values and the other brain regions relative to the healthy controls. CONCLUSIONS Significant correlations were found between thalamic rCBF values and pain belief values. These data suggest that there are baseline alterations of brain perfusion in patients with FM. rCBF values of the thalami exhibited lower correlations with respect to other brain regions thought to be involved in pain processing compared with those in healthy controls.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Cerebral Blood Flow Alterations in Pain-Processing Regions of Patients with Fibromyalgia Using Perfusion MR Imaging

Foerster¹,

Petrou²,

Harris³

et al. 2011

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…Using a similar technique, Jones et al have demonstrated that patients suffering from chronic functional facial pain show an exaggerated response of anterior cingulate cortex and a reduced response of prefrontal cortex to an acute somatic heat pain stimulus (19). Mountz et al have recently reported abnormalities of rCBF in the thalamus and caudate nucleus associated with low somatic pain thresholds in female patients with FM (30). These studies, using single-photon-emission computed tomography (SPECT) indicate that rCBF in the left and right hemithalami and left and right caudate nucleus were significantly lower in women with FM than in normal controls.…”

Section: Evidence For Alteration In Central Processing Of Sensory Infmentioning

confidence: 93%

The Association of Functional Gastrointestinal Disorders and Fibromyalgia

Chang¹

1998

European Journal of Surgery

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Previous epidemiological studies have confirmed the clinical impression that functional gastrointestinal disorders typically overlap with fibromyalgia (FM) in the same patient, suggesting a common etiology. FM syndrome occurs in up to 60% of patients with functional bowel disorders. Up to 50% of patients with a diagnosis of FM syndrome complain of symptoms characteristic of functional dyspepsia and 70% have symptoms of IBS. These two conditions have common clinical characteristics: (1) the majority of patients associate stressful life events with the initiation or exacerbation of symptoms, (2) the majority of patients complain of disturbed sleep and fatigue, (3) psychotherapy and behavioral therapies are efficacious in treating symptoms, and (4) low-dose tricyclic antidepressant medication can improve symptoms. Despite these similarities, their perceptual responses to both somatic and visceral stimuli differ. While FM patients characteristically exhibit somatic hyperalgesia, IBS patients without coexistent FM have somatic hypoalgesia to mechanical stimuli. Visceral distention studies have also demonstrated perceptual alterations in patients with IBS and FM although these findings appear to differ in the two conditions. Further studies will help explore the mechanisms which are responsible for the similarities and differences in clinical symptoms and physiologic parameters seen in IBS and FM.

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Fibromyalgia Syndrome a Decade Later

Goldenberg¹

1999

Arch Intern Med

188

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Fibromyalgia in women

Cited by 338 publications

References 64 publications

Cerebral Blood Flow Alterations in Pain-Processing Regions of Patients with Fibromyalgia Using Perfusion MR Imaging

Cerebral Blood Flow Alterations in Pain-Processing Regions of Patients with Fibromyalgia Using Perfusion MR Imaging

The Association of Functional Gastrointestinal Disorders and Fibromyalgia

Fibromyalgia Syndrome a Decade Later

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