Fibronectin and laminin in Achilles tendon

Józsa, László; Lehto, Matti; Kannus, Pekka; Kvist, M; Réffy, A; Vieno, Toini; Järvinen, Markku; S, Demel; Elek, E

doi:10.3109/17453678909149322

Cited by 54 publications

(25 citation statements)

References 12 publications

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“…In our previous studies, fibronectin exudates were frequently found in the paratenon of Achilles tendons with fibronectin deposits in the ruptured tendon, implying extravasation of plasma proteins [16,24]. These observations, together with the present findings, indicate that the paratenon is affected.…”

Section: Discussionsupporting

confidence: 72%

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Vascular changes in the ruptured achilles tendon and paratenon

Kvist

Józsa²,

Järvinen

1992

International Orthopaedics

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Thirty patients with ruptures of the Achilles tendon were studied. There were 21 men and 9 women with an average age of 36 years. Specimens from the tendon and paratenon in 24 were examined histologically. Tissue samples of 20 were studied by electron microscopy. Marked degenerative, obliterative and/or inflammatory vascular changes were found in all the ruptured tendons and their paratenon. Our findings indicate that poor vascularity play a role in the aetiology of rupture of the Achilles tendon.

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Section: Discussionsupporting

confidence: 72%

“…Because ruptures of the Achilles tendon are most often seen in patients in the fourth decade of life creased extravasation [16,24] contributing by this mechanism to the development of pathological changes in the tissue of the tendon.…”

Section: Discussionmentioning

confidence: 99%

Vascular changes in the ruptured achilles tendon and paratenon

Kvist

Józsa²,

Järvinen

1992

International Orthopaedics

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“…Tenascin-C contributes to the mechanical stability of the extracellular matrix through its interaction with collagen fibrils (Elefteriou et al, 2001). Fibronectin is located on the surface of collagens, and its synthesis increases to facilitate wound healing (Jozsa et al, 1989a;Williams et al, 1984). Additionally, tendons contain elastin, which composes about 2% of the dry weight of the tendon (Jozsa et al, 1989b).…”

Section: Tendon Compositionmentioning

confidence: 99%

Mechanobiology of tendon

Wang

2006

Journal of Biomechanics

778

699

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“…Similar to cartilage, the proteoglycans hold water and are necessary for resisting compressive loads. Glycoproteins present in tendon ECM include tenascin-C, which interacts with collagen fibrils to provide mechanical stability of the ECM, and fibronectin, which is located on the surface of collagen and plays a role in wound healing [221, 222]. The ECM is also comprised of elastin which makes up about 2% of the dry weight of tendons and drives recovery of the crimped collagen fibers after stretching [223, 224].…”

Section: Tendons and Ligamentsmentioning

confidence: 99%

Decellularized tissue and cell-derived extracellular matrices as scaffolds for orthopaedic tissue engineering

Cheng

Solorio

Alsberg

2014

Biotechnology Advances

313

283

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The reconstruction of musculoskeletal defects is a constant challenge for orthopaedic surgeons. Musculoskeletal injuries such as fractures, chondral lesions, infections and tumor debulking can often lead to large tissue voids requiring reconstruction with tissue grafts. Autografts are currently the gold standard in orthopaedic tissue reconstruction; however, there is a limit to the amount of tissue that can be harvested before compromising the donor site. Tissue engineering strategies using allogeneic or xenogeneic decellularized bone, cartilage, skeletal muscle, tendon and ligament have emerged as promising potential alternative treatment. The extracellular matrix provides a natural scaffold for cell attachment, proliferation and differentiation. Decellularization of in vitro cell-derived matrices can also enable the generation of autologous constructs from tissue specific cells or progenitor cells. Although decellularized bone tissue is widely used clinically in orthopaedic applications, the exciting potential of decellularized cartilage, skeletal muscle, tendon and ligament cell-derived matrices has only recently begun to be explored for ultimate translation to the orthopaedic clinic.

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Fibronectin and laminin in Achilles tendon

Cited by 54 publications

References 12 publications

Vascular changes in the ruptured achilles tendon and paratenon

Vascular changes in the ruptured achilles tendon and paratenon

Mechanobiology of tendon

Decellularized tissue and cell-derived extracellular matrices as scaffolds for orthopaedic tissue engineering

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