Fibrosarcoma arising in the paranasal sinus: a clinicopathological and radiological analysis

Zeng, Junjie; Liu, Huaping; Liu, Lizhi; Liao, Weihua; Hu, Ping; Wang, Xiaoyi; Li, Xuejun; Sun, Lun‐Quan; Zhang, Youming; Yi, Xiaoping

doi:10.1259/dmfr.20170459

Cited by 3 publications

(6 citation statements)

References 36 publications

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“…When suspecting PNFS, there are particular findings found on certain modalities that may rule in or out other diagnoses on the differential [35]. One study identified the common CT and MRI features seen in patients with confirmed PNFS [5]. This particular study confirmed that PNFS commonly presents as a solitary lobulated or irregular heterogeneous mass, with either well-or ill-defined margins.…”

Section: Diagnostic Methodsmentioning

confidence: 89%

“…In routine clinical practice, paranasal fibrosarcoma is commonly misdiagnosed as other neoplasms due to its rarity and non-specific symptomatology. Therefore, it is critical to be familiar with the imaging features that differentiate paranasal fibrosarcoma from other malignancies [5]. Additionally, the rarity of the disease and the relatively few studies within the literature examining the imaging characteristics of PNFS continue to make the preoperative diagnosis of PNFS a challenge [5].…”

Section: Diagnostic Methodsmentioning

confidence: 99%

“…Therefore, it is critical to be familiar with the imaging features that differentiate paranasal fibrosarcoma from other malignancies [5]. Additionally, the rarity of the disease and the relatively few studies within the literature examining the imaging characteristics of PNFS continue to make the preoperative diagnosis of PNFS a challenge [5]. It is also critical that physicians be aware of the advantages and disadvantages of the different imaging modalities.…”

Section: Diagnostic Methodsmentioning

confidence: 99%

“…As with other nasal cavity and paranasal sinus pathologies, PNFS often presents with unilateral nasal obstruction and epistaxis, sometimes being mistaken as a papilloma [1]. Previous reports have found associations with age and gender but reports vary [4,5]. Final staging and diagnosis are based on imaging, histopathology, and immunohistochemistry, with a characteristic herringbone arrangement of fibroblasts being pathognomonic [6].…”

Section: Introductionmentioning

confidence: 99%

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Fibrosarcomas of the Paranasal Sinuses: A Systematic Review

Bughrara¹,

Almsaddi²,

John³

et al. 2022

Cureus

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Fibrosarcomas are rare, malignant neoplasms of mesenchymal origin. Fibrosarcomas appear to be sporadic, but cases of fibrosarcomas secondary to radiation of nasopharyngeal carcinomas have been reported. Paranasal sinus fibrosarcomas (PNFS) are even rarer with few cases being reported since the 1950s. There have been several retrospective cohort studies examining PNFS; however, to our knowledge, no comprehensive review exists. This review aims to summarize the findings of all published cases of PNFS from the 1950s to the 2020s. We hope that a comprehensive review will assist in accurate and early diagnoses of PNFS, and help guide treatment as early treatment is associated with a favorable prognosis. This systematic review reports results following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search was conducted on PubMed, Embase, and Cochrane Library. Studies were screened using established inclusion/exclusion criteria. A total of 26 studies were included for data extraction, and relevant data were collected and analyzed. In our study, the most common study type was case reports (n = 19). The most common presentation for PNFS included male gender (n = 17) with maxillary sinus (n = 57) involvement. Patients commonly presented with complaints of nasal obstruction (n = 15), epistaxis (n = 11), and facial fullness/pain (n = 9). Surgical resection was the mainstay treatment, with the use of chemotherapy or radiation depending on surgical margins and resectability. The diagnosis was commonly made with histological analysis. This review of the literature provides a summary and reference of important presenting factors, elements of diagnosis, and treatment options regarding PNFS to help bring awareness and guide the treatment of such a rare disease. Moving forward, there is a greater need for larger standardized studies that can further complement our findings, as well as more consistent reporting of cases.

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Section: Diagnostic Methodsmentioning

confidence: 89%

Section: Diagnostic Methodsmentioning

confidence: 99%

Section: Diagnostic Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fibrosarcomas of the Paranasal Sinuses: A Systematic Review

Bughrara¹,

Almsaddi²,

John³

et al. 2022

Cureus

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“…Patel et al analyzed 51 sinonasal fibrosarcoma patients from the SEER database. They found that the disease-specific survival rate of patients treated with surgery was better than patients treated with primary radiotherapy alone [ 35 , 36 ]. However, there has been no evaluation of postoperative prognosis in patients with fibrosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Score for the Overall Survival Probability Scores of Fibrosarcoma Patients after Surgery: A Novel Nomogram-Based Risk Assessment System

Chen

Chi

Chen

et al. 2021

Journal of Oncology

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Background. The primary purpose of this study was to determine the risk factors affecting overall survival (OS) in patients with fibrosarcoma after surgery and to develop a prognostic nomogram in these patients. Methods. Data were collected from the Surveillance, Epidemiology, and End Results database on 439 postoperative patients with fibrosarcoma who underwent surgical resection from 2004 to 2015. Independent risk factors were identified by performing Cox regression analysis on the training set, and based on this, a prognostic nomogram was created. The accuracy of the prognostic model in terms of survival was demonstrated by the area under the curve (AUC) of the receiver operating characteristic curves. In addition, the prediction consistency and clinical value of the nomogram were validated by calibration curves and decision curve analysis. Results. All included patients were divided into a training set (n = 308) and a validation set (n = 131). Based on univariate and multivariate analyses, we determined that age, race, grade, and historic stage were independent risk factors for overall survival after surgery in patients with fibrosarcoma. The AUC of the receiver operating characteristic curves demonstrated the high predictive accuracy of the prognostic nomogram, while the decision curve analysis revealed the high clinical application of the model. The calibration curves showed good agreement between predicted and observed survival rates. Conclusion. We developed a new nomogram to estimate 1-year, 3-year, and 5-year OS based on the independent risk factors. The model has good discriminatory performance and calibration ability for predicting the prognosis of patients with fibrosarcoma after surgery.

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