Fibrosarcome infantile simulant un hémangiome type rapidly involuting congenital hemangioma (RICH)

Cissé, Mamadou; Machet, L.; Touze, Anne Le; Machet, M.C.; Lejars, Odile; Lorette, G

doi:10.1016/j.annder.2007.01.002

Cited by 7 publications

(10 citation statements)

References 9 publications

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“…Even after tissue biopsy, the diagnosis of these cutaneous masses may be unclear. Previous reports have described hypervascular variants of CIFS that appeared histologically similar to vascular lesions including a kaposiform hemangioendothelioma, a vascular malformation and a hemangioma . In our case, the telescoping punch biopsy allowed for inspection of only the periphery of the tumor as it infiltrated out through the subcutis.…”

Section: Discussionmentioning

confidence: 71%

“…Previous reports have described hypervascular variants of CIFS that appeared histologically similar to vascular lesions including a kaposiform hemangioendothelioma, a vascular malformation and a hemangioma. 10,14,17 In our case, the telescoping punch biopsy allowed for inspection of only the periphery of the tumor as it infiltrated out through the subcutis. It was difficult to judge the degree of vascularity at the core of the tumor, as the sampled portion did not display prominent vasculature, and the treating physicians did not elect for definitive resection.…”

Section: -11mentioning

confidence: 83%

“…Only 13 cases of CIFS presenting as a cutaneous lesion – including our own – have been reported . The age at diagnosis ranges from 1 day to 6 months, with an average of 66.8 days (Table ).…”

Section: Discussionmentioning

confidence: 99%

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Congenital infantile fibrosarcoma mimicking a cutaneous vascular lesion: a case report and review of the literature

et al. 2016

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Congenital infantile fibrosarcoma (CIFS) is a rare neoplasm of infancy that occurs most frequently in the extremities, and when presenting in the skin, may sometimes resemble infantile hemangiomas or other vascular lesions. Clinically, these tumors differ from hemangiomas in the time of onset, morphology, and growth pattern and must be evaluated histologically for definitive diagnosis. We describe an infant with a neoplasm involving the distal left forearm initially presumed to be a vascular lesion after evaluation by two separate ultrasound studies. He presented at seven weeks of life with a multinodular lesion that had enlarged significantly since birth, and the skin biopsy revealed a fibrosarcoma. This case highlights an unusual cutaneous presentation of CIFS, which varies in appearance from the previous 12 cases reported in the literature. We review the clinical manifestations of these congenital masses and emphasize early diagnosis for conservative therapy and improved prognosis.

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Section: Discussionmentioning

confidence: 71%

Section: -11mentioning

confidence: 83%

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Congenital infantile fibrosarcoma mimicking a cutaneous vascular lesion: a case report and review of the literature

et al. 2016

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“…Sometimes a prominent vascular component is present within the tumor. In these cases, the mass could be clinically interpreted as a vascular lesion, in particular congenital hemangioma [1–11]. Herein we present a case of infantile fibrosarcoma misinterpreted clinically and radiologically as a vascular malformation.…”

Section: Introductionmentioning

confidence: 99%

Infantile Fibrosarcoma—A Clinical and Histologic Mimicker of Vascular Malformations: Case Report and Review of the Literature

Chou

Jennings

et al. 2013

Pediatr Dev Pathol

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Infantile fibrosarcoma is a rare soft tissue tumor that usually presents either at birth or in the 1st year of life. Here we describe a case of a 4-month-old female who presented with a congenital right axillary mass. The initial clinical impression was benign vascular/lymphatic malformation. The core biopsy showed a spindle cell lesion with abundant vasculature represented by small vascular channels. However, immunohistochemical analysis did not support a diagnosis of vascular lesion/tumor. Polymerase chain reaction study for ETS Translocation Variant 6/neurotrophic tyrosine kinase receptor, type 3 fusion transcript was positive, and the diagnosis of infantile fibrosarcoma was established. The patient underwent resection of the axillary mass. Microscopic examination of the resection specimen showed numerous vascular channels. Intermixed there were also cellular areas composed of spindle cells similar to those seen in the biopsy material. Molecular studies were repeated and confirmed the diagnosis of infantile fibrosarcoma. Infantile fibrosarcoma has been previously reported in the literature to clinically masquerade as hemangioma. In addition, this case proves that infantile fibrosarcoma could also mimic vascular malformations on clinical, radiologic, and pathologic exams. In fact, the vascular component of the tumor is very unusual in our patient and represents a histologic feature that has not been described before. The case highlights the diagnostic challenges at clinical, radiologic, and pathologic levels in some cases of infantile fibrosarcoma and raises awareness among clinicians and pathologists related to another peculiar pattern that can be encountered in this disease.

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“…ETV6–NTRK3 fusion is found in almost all cases of infantile fibrosarcoma, and is now considered to be the most reliable molecular genetic marker distinguishing other fibrotic lesions of childhood 5 . Other conditions, which are sometimes difficult to distinguish from infantile fibrosarcoma, such as infantile myofibromatosis 7 or rapidly involuting congenital hemangioma, 8 have been shown to be differentiated by this genetic approach. ETV6–NTRK3 fusion can be established by RT–PCR and/or FISH in paraffin‐embedded tissue sections.…”

mentioning

confidence: 99%

Cranial fasciitis resembling infantile fibrosarcoma differentiated by genetic assay

Imafuku¹,

Takahashi²,

Hashizumi³

et al. 2011

The Journal of Dermatology

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Fibrosarcome infantile simulant un hémangiome type rapidly involuting congenital hemangioma (RICH)

Cited by 7 publications

References 9 publications

Congenital infantile fibrosarcoma mimicking a cutaneous vascular lesion: a case report and review of the literature

Congenital infantile fibrosarcoma mimicking a cutaneous vascular lesion: a case report and review of the literature

Infantile Fibrosarcoma—A Clinical and Histologic Mimicker of Vascular Malformations: Case Report and Review of the Literature

Cranial fasciitis resembling infantile fibrosarcoma differentiated by genetic assay

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