Fibrous Hamartoma of Infancy: Current Review

Abstract

This review examines 197 cases of fibrous hamartoma of infancy (FHI) described in the literature and provides a detailed clinicopathologic analysis of what is known to date of this peculiar lesion of the subcutis and lower dermis. The vast majority of these cases occurred within the first year of life (91%). Twenty-three percent were congenital. There was a predilection for boys with a male/female ratio of 2.4. Males and females had similar anatomic distribution with the most common locations being the axillary region, upper arm, upper trunk, inguinal region, and external genital area. Most cases presented as solitary masses, but four cases of multiple separate synchronous lesions have been reported. Most lesions presented as a painless nodule, sometimes with rapid growth. A few cases had overlying skin changes, including alteration in pigmentation, eccrine gland hyperplasia, and increased hair. No lesions were reported to have familial or syndromic association, or to occur in combination with other hamartomas. Spontaneous regression has not been reported. The treatment of choice is local excision. Even with incomplete excision, FHI has a low recurrence rate. Criteria for histologic diagnosis include the presence of well-defined bundles of dense, uniform, fibrous connective tissue projecting into fat, primitive mesenchyme arranged in nests, concentric whorls or bands, and mature adipose tissue intimately admixed with the other components. Flow-cytometric and conventional cytogenetic studies have not been reported; these may clarify any relationship to other fibroblastic/myofibroblastic proliferations in children, resulting in better classification and terminology of this unique lesion.

A Rare Cause of Positional Dyspnea: Hypopharyngeal Hamartoma

“…Hamartomas are tumor-like benign formations that can be observed in all body parts and that occur because of the abnormal growth of tissue in an unusual amount and with an unusual mixture of cells (4). While most hamartomas are mesenchymal ones that do not include an epithelial tissue and that develop because of an abnormal growth of the mesenchymal tissue, epithelial-glandular hamartomas, which include a mixture of epithelial and glandular components, are less frequently observed (5).…”

Soft Tissue Ankle Mass in a 15-month-old Girl

“…This lesion commonly involves the muscles of the head, neck, and proximal extremities, similar to fibrous hamartoma of infancy. It is also a benign soft tissue tumor that presents during the first 2 years of life [3,4,8]. Histologic interpretation can be classified as diffuse or desmoid types.…”

Solunum sıkıntısı olan bir yenidoğan

“…In the etiology of hamartomas, causes including congenital malformation, hyperplasia of normal tissue and response to inflammation have been considered (1,3). Hamartomas usually occur as a painless mass and rapid growth may be seen in some cases.…”

“…Hamartomas usually occur as a painless mass and rapid growth may be seen in some cases. Familial characteristics or association with syndromes could not be demonstrated (1,4). Hamartomas can reach a diameter of 15 cm, but they are usually 2.5-5 cm in diameter (3).…”

“…Hamartomas can reach a diameter of 15 cm, but they are usually 2.5-5 cm in diameter (3). Differentiating this tumor-like mass from other pathologies including lymphadenomegaly, sarcoma, lipoma, hemangioma, neurofibroma, dermatofibroma or teratoma by detailed investigation is essential in terms of treatment approach (1,(3)(4)(5).…”