Throughout human exploration of space, analog missions have proven to be a critical aspect in reducing risk while increasing technical and operational experience. In light of the new goals associated with the Vision for Space Exploration (VSE), the prior processes and procedures for analog missions are not adequate to meet the objectives of the VSE. To solve this problem, previous analog work was analyzed to uncover gaps in the current system of creating and running analog missions. Then, a Systems Engineering approach to the design process of analogs was created, which includes outlining the analog, documenting it in NASA's Analogs Database, using checklists to ensure all elements of the analog are being considered, and creating a quantitative trade study with consistent metrics. A trade study can be used to compare the fidelity of analog missions and to ensure that the analog missions closely match the actual spaceflight mission. Overall, the Systems Engineering approach can be applied to analog missions so that the analog missions meet the objectives of the Vision for Space Exploration through high fidelity, consistency, and collaboration.