Fiebre chikungunya. Manifestaciones reumáticas de una infección emergente en Europa

Horcada, M. Loreto; Díaz-Calderón, Carlos; Garrido, Laura

doi:10.1016/j.reuma.2014.07.005

Cited by 35 publications

(14 citation statements)

References 24 publications

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“…Most infected patients become symptomatic, and the disease progresses through three phases: an acute phase, which can last up to 10 days and is characterized by fever, pain, periarticular edema, and, in many cases, rash (2) ; a subacute phase, typically lasting from day 11 to month 3, in which rheumatic symptoms, characterized by synovitis (of the large and small joints) and tenosynovitis, predominate; and a chronic phase, beginning after the third month of evolution, in which there is persistence of inflammatory symptoms at some sites, myalgia, and peripheral nerve compressive syndromes. A small percentage of patients in the chronic phase develop profiles resembling that of rheumatoid arthritis, and the main finding on imaging studies is joint erosion (1,5,6) .…”

Section: Introductionmentioning

confidence: 99%

Ultrasound of ankles in the diagnosis of complications of chikungunya fever

et al. 2017

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ObjectiveTo describe the main ultrasound findings of chikungunya fever in the ankle.Materials and MethodsThis was a cross-sectional observational study involving 52 patients referred to the Hospital Universitário Pedro Ernesto and presenting with clinical and biochemical evidence of chikungunya fever. The examinations were performed by a radiologist with more than 20 years of experience in ultrasound.ResultsThe predominant gender was female (in 88.5%), and the mean age was 58.4 years. The majority (61.5%) of the patients came from the northern part of the city of Rio de Janeiro, and 46.2% were using corticosteroids to treat inflammatory symptoms. The most common alterations observed by ultrasound were joint effusion (in 69.2%), tenosynovitis (in 59.6%), cellulitis (in 46.2%), Kager's fat pad thickening (in 29.9%), myositis (of the soleus or flexor hallucis longus muscle) (in 17.3%), retrocalcaneal bursitis (in 5.8%), tendon ruptures (in 3.8%), and increased vascular flow on power Doppler (in 3.8%).ConclusionSigns of synovitis and tenosynovitis were the main ultrasound findings in a predominantly female population with a mean age of 58.4 years. Further studies are needed in order to define the role of ultrasound in the follow-up of such patients.

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Section: Introductionmentioning

confidence: 99%

Ultrasound of ankles in the diagnosis of complications of chikungunya fever

et al. 2017

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“…Biochemical confirmation is absolutely necessary in order to differentiate the symptoms and make the differential diagnosis with other diseases transmitted by Aedes mosquitoes, such as dengue, that are endemic to the same geographic areas. To make the definitive diagnosis of chikungunya fever, the presence of the virus in the blood should be demonstrated directly by means of viral RNA determination at the peak of viremia; that is, 5–10 days after the onset of symptoms (1,2) . There are currently few therapeutic options, and symptomatic treatment produces only a slow, moderate response (1) .…”

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confidence: 99%

“…In chikungunya fever, there is a high incidence of recurrence and chronicity of joint involvement, with persistence of the inflammatory symptoms (1,2) . In the chronic phase, the disease presents aspects quite similar to those of rheumatoid arthritis, including bilateral, symmetric chronic polyarthritis with a migratory pattern, and the prevalence of rheumatoid factor positivity ranges from 25% to 43% (1,2) .…”

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confidence: 99%

“…In the chronic phase, the disease presents aspects quite similar to those of rheumatoid arthritis, including bilateral, symmetric chronic polyarthritis with a migratory pattern, and the prevalence of rheumatoid factor positivity ranges from 25% to 43% (1,2) . After the initial manifestations, there can be recurrence of the arthritis, the rate of such recurrence decreasing over time, from 88–100% in the first six weeks to 12% by five years.…”

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Imaging findings in chikungunya fever

Canella

2017

Radiol Bras

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“…Some alphaviruses are emerging pathogens, including chikungunya virus, VEEV, MAYV, and EEEV (Figueiredo 2007; Cassadou et al 2014; Fischer and Staples 2014; Horcada et al 2015). Three of these (VEEV, EEEV, and MAYV) are zoonotic and widespread in South America (Hubalek et al 2014).…”

Section: Introductionmentioning

confidence: 99%

SEROSURVEY OF SELECTED ARBOVIRAL PATHOGENS IN FREE-RANGING, TWO-TOED SLOTHS (CHOLOEPUS HOFFMANNI) AND THREE-TOED SLOTHS (BRADYPUS VARIEGATUS) IN COSTA RICA, 2005–07

Medlin¹,

Deardorff²,

Hanley

et al. 2016

Journal of Wildlife Diseases

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We screened for antibodies to 16 arboviruses in four populations of free-ranging sloths in Costa Rica. Blood samples were taken from 16 Hoffman’s two-toed sloths (HTSs; CHOLOEPUS HOFFMANNI) and 26 brown-throated sloths (BTSs; BRADYPUS VARIEGATUS) over a 3-yr period. We used serologic assays to detect antibodies against 10 arboviruses previously described in sloths (St. Louis encephalitis [SLEV], Changuinola, Venezuelan equine encephalitis, Ilheus [ILHV], Oropouche, Mayaro, Utinga, Murutucu, Punta Toro, and vesicular stomatitis [VSV] viruses) and six arboviruses not described in sloths (Rio Grande, West Nile [WNV], eastern equine encephalitis, Piry, Munguba, and La Crosse viruses). Overall, 80% of sloths had detectable antibodies to SLEV, 67% had antibodies to ILHV, 32% to Punta Toro virus, 30% to Changuinola virus, 15% to WNV, 14% to VSV, 11% to Venezuelan equine encephalitis virus, and 10% to Rio Grande virus. No samples had detectable antibodies to the remaining eight viruses. We found a significant increase in prevalence of antibody to VSV in HTSs between 2005 and 2007, and for WNV antibody between 2005 and 2006. We found no significant differences in the prevalences of antibodies to the sampled viruses between the two locations. Antibody prevalences were significantly higher in HTSs than in BTSs for SLEV in 2005. Antibody-positive results for ILHV were likely due to cross-reaction with SLEV. The novel finding of antibodies to Rio Grande virus in sloths could be due to cross-reaction with another phlebovirus. These findings might have implications for land management and domestic animal health. Due to the nature of the study, we could not determine whether sloths could represent amplification hosts for these viruses, or whether they were only exposed and could be used as sentinel species. Further studies are needed to fully characterize arboviral exposure in sloths.

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Fiebre chikungunya. Manifestaciones reumáticas de una infección emergente en Europa

Cited by 35 publications

References 24 publications

Ultrasound of ankles in the diagnosis of complications of chikungunya fever

Ultrasound of ankles in the diagnosis of complications of chikungunya fever

Imaging findings in chikungunya fever

SEROSURVEY OF SELECTED ARBOVIRAL PATHOGENS IN FREE-RANGING, TWO-TOED SLOTHS (CHOLOEPUS HOFFMANNI) AND THREE-TOED SLOTHS (BRADYPUS VARIEGATUS) IN COSTA RICA, 2005–07

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