ObjectivesTo investigate the primary respiratory manifestations (PRM) in SLE.MethodsAll patients in the RELESSER cohort were retrospectively investigated for the presence of PRMResultsAt least one PRM was present in 11.3% (365/3215) of cases. The most common was pleurisy, occurring in 21.1% of patients, followed by ALP in 3.6%, PE in 2.9%, PPH 4%, DILD in 2%, DAH in 0.8%, and SLS in 0.8%.The variables associated with the presence of PPM are shown in the following table 1:Odds Ratio95%
ConfidenceIntervalP
Age1,031,02–1,040.000SLEDAI score1,031,00–1,070,02Raynaud phenomenon1,411,09–1,840,01Severe nephritis1,561,18–2,060002Secondary APS2,21,63–2,970.000Anti-RNP positivity1,321,00–1,750054Cardiac disease2,811,90–4,160000Vasculitis1,811,25–2,620002Hematologic abnormalities1,311,00–1,710048Neuropsychiatric manifestations1,491,11–2.020009Gastrointestinal involvement2,051,14–3,670016After adjusting for known confounders in the multivariable model, PPM remained a risk factor for diminished survival (HR: 3.13).ConclusionsPPM independently contributed to a decreased survival in SLEDisclosure of InterestNone declared
