As societal dependence on transionospheric radio signals grows, space weather impact on these signals becomes increasingly important yet our understanding of the effects remains inadequate. This challenge is particularly acute at high latitudes where the effects of space weather are most direct and no reliable predictive capability exists. We take advantage of a large volume of data from Global Navigation Satellite Systems (GNSS) signals, increasingly sophisticated tools for data-driven discovery, and a machine learning algorithm known as the support vector machine (SVM) to develop a novel predictive model for high-latitude ionospheric phase scintillation. This work, to our knowledge, represents the first time an SVM model has been created to predict high-latitude phase scintillation. We use the true skill score to evaluate the SVM model and to establish a benchmark for high-latitude ionospheric phase scintillation prediction. The SVM model significantly outperforms persistence (i.e., current and future scintillation are identical), doubling the predictive skill according to the true skill score for a 1-hr lead time. For a 3-hr lead time, persistence is comparable to a random chance prediction, suggesting that the memory of the ionosphere in terms of high-latitude plasma irregularities is on the order of, or shorter than, a few hours. The SVM model predictive skill only slightly decreases between the 1-and 3-hr predictive tasks, pointing to the potential of this method. Our findings can serve as a foundation on which to evaluate future predictive models, a critical development toward the resolution of space weather impact on transionospheric radio signals.Plain Language Summary Society is increasingly dependent on radio signals, particularly those from the Global Navigation Satellite Systems (GNSS), and the technologies (e.g., navigation and financial transactions) that they enable. The integrity and reliability of these signals is threatened by their travel from the GNSS satellites to the ground, which includes passage through a charged region between 100 and 1,000 km known as the ionosphere. Disturbances to the ionosphere from solar energy, or space weather, cause variations in GNSS signals that adversely affect the dependent systems and technologies. Currently, the effect of the ionosphere on these signals cannot be reliably predicted, and the challenge is particularly important at latitudes above 45 ∘ where space weather impacts are most direct. We have compiled a large volume of data from the regions important to space weather (i.e., from the Sun to the Earth) to develop a novel machine learning model capable of skillfully predicting disruptions to GNSS signals at high latitudes.To our knowledge, this model is the first of its kind. We find that the new model is capable of more accurate predictions than current methods and position this model as a benchmark on which future predictive models can be measured.