Field efficacy of mandipropamid for the control of potato late blight

Rekanović, Emil; Stepanović, Miloš; Stević, Milan; Potočnik, Ivana; Todorović, Biljana; Milijasevic-Marcic, Svetalana

doi:10.2298/pif1002157r

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…It was first introduced in 1977, and has since been considered an important tool to protect grape and vegetable crops from oomycete pathogens of the Peronosporales order [2]. In practical applications, CYM effectively combats downy mildew diseases caused by Plasmopara viticola in grapevine cultures and late blight diseases triggered by Phytophthora infestans in tomato and potato crops [3,4]. Due to its weak persistence (half-life of a few days, depending on the conditions) and mobile nature (adsorption coefficient, KOC 39-238), CYM displays a relatively short period of activity when used alone [5].…”

Section: Introductionmentioning

confidence: 99%

The widely used cymoxanil fungicide impairs respiration inSaccharomyces cerevisiaevia cytochromecoxidase inhibition

Mendes,

Santos-Pereira,

Vieira

et al. 2024

Preprint

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Cymoxanil (CYM) is a synthetic acetamide fungicide that has been widely used to combat downy mildew diseases in grapevine cultures and late blight diseases in tomato and potato caused by the oomycetesPlasmopara viticolaandPhytophthora infestans, respectively. Despite its extensive application, the biochemical mode of action of CYM remains elusive. Previous reports indicate that CYM affects growth, DNA and RNA synthesis inPhytophthoraand inhibits cell growth, biomass production and respiration rate in the well-characterized fungal modelSaccharomyces cerevisiae. We therefore used this model to further characterize the effect of CYM on mitochondria. We found that CYM inhibits oxygen consumption in whole cells after 3 h of exposure, which persists over time. Using isolated mitochondria, we demonstrated that CYM specifically inhibits cytochromecoxidase (CcO) activity during oxidative phosphorylation. Based on molecular docking algorithms, we propose that CYM acts by blocking the interaction of cytochromec(cytc) with CcO, hampering electron transfer and inhibiting CcO catalytic activity. Although other targets cannot be excluded, our data offer valuable insights into the mode of action of CYM that can be instrumental to drive informed management of the use of this fungicide.

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Section: Introductionmentioning

confidence: 99%

The widely used cymoxanil fungicide impairs respiration inSaccharomyces cerevisiaevia cytochromecoxidase inhibition

Mendes,

Santos-Pereira,

Vieira

et al. 2024

Preprint

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“…For example, Rekanović et al. (2010), Töfoli et al. (2016), and Fanigliulo and Sacchetti (2009) also reported that racemic mandipropamid was effective against potato late blight, potato early blight ( Alternaria solani ), and Phytophthora infestans on tomato ( Solanum lycopersicum L.), respectively.…”

Section: Introductionmentioning

confidence: 99%

“…Mandipropamid, the chemical structure of which is demonstrated in Supplemental Figure S1, is a new chiral carboxylic acid amide (CAA) fungicide with extremely high activity against plant oomycete pathogens such as P. viticola and P. infestans; this pesticide works to inhibit mycelial growth and sporulation by nhibiting cell wall synthesis (Blum et al, 2010). For example, Rekanović et al (2010), Töfoli et al (2016), and Fanigliulo and Sacchetti (2009) also reported that racemic mandipropamid was effective against potato late blight, potato early blight (Alternaria solani), and Phytophthora infestans on tomato (Solanum lycopersicum L.), respectively. After application, a large amount of mandipropamid could be absorbed in the cuticular wax layer, ensuring excellent rainfastness, which meant good persistence of its bioactivity (Fanigliulo & Sacchetti, 2009).…”

Section: Introductionmentioning

confidence: 99%

Enantioselective environmental behavior of the chiral fungicide mandipropamid in four types of Chinese soil

Han

Chen

Liu

et al. 2021

Soil Science Soc of Amer J

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Enantioselective degradation behavior of mandipropamid, and factors affecting its degradation and metabolites in four types of Chinese soil were investigated in this work. The results showed that the enantiomeric selectivity values ranged from 0.025 to 0.170, indicating that enantioselectivity was found in the degradation process of the racemate in all of the soil samples and that the R-(−)-enantiomer was preferentially degraded. The degradation compounds formed faster in native alkaline soils (half-lives = 35.5-39.80 d) than in native acidic soils (half-lives = 51.3-77.90 d). The half-lives of the R-(−)-enantiomer and S-(+)-enantiomer were 35.5-73.7 and 37.5-77.9 d, 66.6-97.6 and 70.0-103.5 d, and 52.5-110.0 and 66.0-144.4 d in the fourtypes of soil under native, sterilized, and organic matter-removed conditions, respectively, which indicated that mandipropamid degradation can be attributed to microbial activity and the organic matter content in the soil. Furthermore, the half-lives of the R-(−)-enantiomer and S-(+)-enantiomer decreased 1.07-1.95 and 1.08-1.79 times with each 10˚C increase in incubation temperature, and the half-lives of the R-(−)-enantiomer and S-(+)-enantiomer decreased 1.09-1.43 and 1.06-1.50 times with increasing moisture content. However, the incubation temperature and soil moisture did not change the enantioselectivity. Mandipropamid enantiomers were observed to be configurationally stable in the selected soil, and no interconversion was found during the incubation of enantiopure R-(−)-mandipropamid or S-(+)-mandipropamid in native or sterilized soil. During the degradation process, four major metabolites were detected. In comprehensive consideration of the environmental behavior, the enantioselective degradation results should be considered to more accurately assess the risk of this chiral pesticide in a real environment.

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Enantioselective evaluation of the chiral fungicide mandipropamid: Dissipation, distribution and potential dietary intake risk in tomato, cucumber, Chinese cabbage and cowpea

Lan

Yang

et al. 2022

Ecotoxicology and Environmental Safety

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Field efficacy of mandipropamid for the control of potato late blight

Cited by 3 publications

References 6 publications

The widely used cymoxanil fungicide impairs respiration inSaccharomyces cerevisiaevia cytochromecoxidase inhibition

The widely used cymoxanil fungicide impairs respiration inSaccharomyces cerevisiaevia cytochromecoxidase inhibition

Enantioselective environmental behavior of the chiral fungicide mandipropamid in four types of Chinese soil

Enantioselective evaluation of the chiral fungicide mandipropamid: Dissipation, distribution and potential dietary intake risk in tomato, cucumber, Chinese cabbage and cowpea

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