Field evaluation of a quantitative, and rapid malaria diagnostic system using a fluorescent Blue-ray optical device

Mita, Toshihiro; Yamamoto, Takeki; Hashimoto, Muneaki; Nagatomi, Kenji; Nogami, Takahiro; Sofue, Yasuyuki; Hayashi, Takuya; Ido, Yusuke; Yatsushiro, Shouki; Abe, Kaori; Kajimoto, Kazuaki; Tamari, Noriko; Awuor, Beatrice; Sonye, George; Kongere, James; Munga, Stephen; Ohashi, Jun; Oka, Hiroaki; Minakawa, Noboru; Kataoka, Masatoshi

doi:10.1101/721076

Cited by 4 publications

(5 citation statements)

References 37 publications

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“…In addition to identifying new candidate makers for severe malaria, new diagnostic tools for detecting malaria parasites are challenging. Recently, magnetic resonance relaxometry (MRR) [ 73 , 74 , 75 ], on-chip nuclear magnetic resonance (NMR) [ 76 ], rotating-crystal magneto-optical detection (RMOD) [ 77 ], and fluorescent blue-ray optical devices [ 78 ] have emerged as high-sensitivity malaria diagnostic tools to detect low parasite density in asymptomatic individuals. These new diagnostic tools will help increase the detection of malaria parasites and provide early treatment to patients, which can reduce malaria transmission, reducing the rate of misdiagnosis or mis-treatment that can facilitate severe malaria or anti-malarial drug resistance.…”

Section: Discussionmentioning

confidence: 99%

“…knowlesi malaria can be found in the changing patterns in land use where spillover opportunities for human infection due to increased contact with natural reservoirs and infected vectors have been aggravated. In addition, the range and distribution of primary hosts and vectors including their bionomics are still lacking in data [ 78 ]. These are strong rationales to conduct further studies on the parasite, vector, and host biology in non- P .…”

Section: Discussionmentioning

confidence: 99%

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Alteration of Platelet Count in Patients with Severe Non-Plasmodium falciparum Malaria: A Systematic Review and Meta-Analysis

Mahittikorn

Masangkay

Kotepui

et al. 2021

Biology

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The understanding of platelet biology under physiological and pathological conditions like malaria infection is critical importance in the context of the disease outcome or model systems used. The importance of severe thrombocytopenia (platelet count < 50,000 cells (µL) and profound thrombocytopenia (platelet count < 20,000 cells/µL) in malaria patients remains unclear. This study aimed to synthesize evidence regarding the risks of severe and profound thrombocytopenia in patients with severe non-Plasmodium falciparum malaria. Our overall aim was to identify potential indicators of severe non-P. falciparum malaria and the Plasmodium species that cause severe outcomes. This systematic review was registered at the International Prospective Register of Systematic Reviews (PROSPERO) under registration ID CRD42020196541. Studies were identified from previous systematic reviews (n = 5) and the MEDLINE, Scopus, and Web of Science databases from 9 June 2019 to 9 June 2020. Studies were included if they reported the outcome of severe non-Plasmodium species infection, as defined by the World Health Organization (WHO) criteria, in patients with known platelet counts and/or severe and profound thrombocytopenia. The risk of bias was assessed using the Newcastle–Ottawa Scale (NOS). Data were pooled, and pooled prevalence (PP) and pooled odds ratios (ORs) were calculated using random effects models. Of the 118 studies identified from previous meta-nalyses, 21 met the inclusion criteria. Of the 4807 studies identified from the databases, three met the inclusion criteria. Nine studies identified from reference lists and other sources also met the inclusion criteria. The results of 33 studies reporting the outcomes of patients with severe P. vivax and P. knowlesi infection were pooled for meta-analysis. The PP of severe thrombocytopenia (reported in 21 studies) was estimated at 47% (95% confidence interval (CI): 33–61%, I2: 96.5%), while that of profound thrombocytopenia (reported in 13 studies) was estimated at 20% (95% CI: 14–27%, 85.2%). The pooled weighted mean difference (WMD) in platelet counts between severe uncomplicated Plasmodium infections (reported in 11 studies) was estimated at −28.51% (95% CI: −40.35–61%, I2: 97.7%), while the pooled WMD in platelet counts between severe non-Plasmodium and severe P. falciparum infections (reported in eight studies) was estimated at −3.83% (95% CI: −13.90–6.25%, I2: 85.2%). The pooled OR for severe/profound thrombocytopenia comparing severe to uncomplicated Plasmodium infection was 2.92 (95% CI: 2.24–3.81, I2: 39.9%). The PP of death from severe and profound thrombocytopenia was estimated at 11% (95% CI: 0–22%). These results suggest that individuals with severe non-P. falciparum infection (particularly P. vivax and P. knowlesi) who exhibit severe or profound thrombocytopenia should be regarded as high risk, and should be treated for severe malaria according to current WHO guidelines. In addition, severe or profound thrombocytopenia coupled with other clinical and microscopic parameters can significantly improve malaria diagnosis, enhance the timely treatment of malaria infections, and reduce the morbidity and mortality of severe non-P. falciparum malaria.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Alteration of Platelet Count in Patients with Severe Non-Plasmodium falciparum Malaria: A Systematic Review and Meta-Analysis

Mahittikorn

Masangkay

Kotepui

et al. 2021

Biology

View full text Add to dashboard Cite

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“…Given the wide range of thematic areas discussed, we acknowledge that we have only scratched the surface of the various cross-cutting topics. Consequently, we did not elaborate on the host immune response to malaria nor on technological advances in diagnosing and treating malaria since they are widely covered elsewhere [ 89 , 90 , 91 , 92 , 93 , 94 ]. Additionally, this paper faces two challenges, namely (1) a self-selection bias that might lead to a more prominent emphasis on some cross-cutting topics, and (2) not considering recently published papers [ 95 ].…”

Section: Discussionmentioning

confidence: 99%

An Overview of Malaria Transmission Mechanisms, Control, and Modeling

Savi

2022

Medical Sciences

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In sub-Saharan Africa, malaria is a leading cause of mortality and morbidity. As a result of the interplay between many factors, the control of this disease can be challenging. However, few studies have demonstrated malaria’s complexity, control, and modeling although this perspective could lead to effective policy recommendations. This paper aims to be a didactic material providing the reader with an overview of malaria. More importantly, using a system approach lens, we intend to highlight the debated topics and the multifaceted thematic aspects of malaria transmission mechanisms, while showing the control approaches used as well as the model supporting the dynamics of malaria. As there is a large amount of information on each subject, we have attempted to provide a basic understanding of malaria that needs to be further developed. Nevertheless, this study illustrates the importance of using a multidisciplinary approach to designing next-generation malaria control policies.

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“…The implementation of such technology-driven or omics-based systems throughout endemic areas could prevent aggressive treatments and related side effects. [ 33 , 34 , 35 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Treatment for Severe Malaria: Post-Artesunate Delayed Haemolysis and Neutropenia

et al. 2022

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Parenteral artesunate (AS) is the WHO first-line treatment recommended in adults and children for severe malaria. Post-artesunate delayed haemolysis (PADH) is an uncommon adverse reaction to AS with a mechanism that is not fully understood, occurring in adults and children. Neutropenia is another possible finding after AS treatment, albeit rare. We present the case of a child who experienced both effects after treatment with AS for imported severe Falciparum malaria with very high parasitaemia. In addition, thirty-five paediatric cases of PADH, five cases of delayed anaemia without known haemolysis, and fourteen cases of neutropenia after artesunate treatment were identified from the literature review. PADH seems to be a dose-independent reaction and is not strongly related to hyperparasitaemia, although it is more frequent in this case. To date, the benefits of AS outweigh its potential side effects. However, haematological follow-up is mandatory to avoid possible complications from anaemia and neutropenia, especially in children treated with other contemporary drugs.

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Field evaluation of a quantitative, and rapid malaria diagnostic system using a fluorescent Blue-ray optical device

Cited by 4 publications

References 37 publications

Alteration of Platelet Count in Patients with Severe Non-Plasmodium falciparum Malaria: A Systematic Review and Meta-Analysis

Alteration of Platelet Count in Patients with Severe Non-Plasmodium falciparum Malaria: A Systematic Review and Meta-Analysis

An Overview of Malaria Transmission Mechanisms, Control, and Modeling

Treatment for Severe Malaria: Post-Artesunate Delayed Haemolysis and Neutropenia

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