Field evaluation of a rapid point-of-care assay for targeting antibiotic treatment for trachoma control: a comparative study

Michel, C; Solomon, Anthony W.; Magbanua, Jose Paolo V.; Massae, Patrick; Huang, Ling; Mosha, Jonaice; West, Sheila K.; Nadala, Cesar; Bailey, Robin L.; Wisniewski, Craig; Mabey, David; Lee, Helen H.

doi:10.1016/s0140-6736(06)68695-9

Cited by 63 publications

(56 citation statements)

References 20 publications

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“…Taken to scale, the advent of simple diagnostic tests for yaws and trachoma could help reduce the need for mass administration of antibiotics, such as azithromycin. [191][192][193] Improved diagnostics can help convert a vicious cycle into a more virtuous one.…”

Section: Innovation In Tackling Antibiotic Resistancementioning

confidence: 99%

Antibiotic resistance—the need for global solutions

Laxminarayan

Dusé

Wattal

et al. 2013

The Lancet Infectious Diseases

3,580

2,602

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The causes of antibiotic resistance are complex and include human behaviour at many levels of society; the consequences aff ect everybody in the world. Similarities with climate change are evident. Many eff orts have been made to describe the many diff erent facets of antibiotic resistance and the interventions needed to meet the challenge. However, coordinated action is largely absent, especially at the political level, both nationally and internationally. Antibiotics paved the way for unprecedented medical and societal developments, and are today indispensible in all health systems. Achievements in modern medicine, such as major surgery, organ transplantation, treatment of preterm babies, and cancer chemotherapy, which we today take for granted, would not be possible without access to eff ective treatment for bacterial infections. Within just a few years, we might be faced with dire setbacks, medically, socially, and economically, unless real and unprecedented global coordinated actions are immediately taken. Here, we describe the global situation of antibiotic resistance, its major causes and consequences, and identify key areas in which action is urgently needed.

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Section: Innovation In Tackling Antibiotic Resistancementioning

confidence: 99%

Antibiotic resistance—the need for global solutions

Laxminarayan

Dusé

Wattal

et al. 2013

The Lancet Infectious Diseases

3,580

2,602

View full text Add to dashboard Cite

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“…Other tests that are more sensitive and specific than the clinical examination, such as a point-of-care assay, may provide cost savings over NAATs. 26 Alternatively, trachoma programs could follow the lead of genital chlamydial research by pooling PCR samples. 27 , 28 Costs for genital Chlamydia screening programs can be cut in half by testing pooled samples and re-analyzing individual samples from positive pools.…”

Section: Discussionmentioning

confidence: 99%

Clinical Activity and Polymerase Chain Reaction Evidence of Chlamydial Infection after Repeated Mass Antibiotic Treatments for Trachoma

Keenan¹,

Lakew²,

Alemayehu³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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It is unclear how the prevalence of clinically active trachoma correlates with the prevalence of ocular chlamydial infection at the community level. In 24 villages from a cluster-randomized clinical trial of mass azithromycin distributions in Ethiopia, the correlation between the prevalence of clinical activity (on examination) and chlamydial infection (by polymerase chain reaction) was moderately strong before mass antibiotic treatments (Pearson's correlation coefficient r = 0.75, 95% confidence interval [CI] = 0.52–0.87), but decreased at each time point during four biannual treatments (at 24 months, r = 0.15, 95% CI = −0.14–0.41). One year after the final treatment, the correlation coefficient had increased, but not to the pre-treatment level (r = 0.55, 95% CI = 0.30–0.73). In a region with hyperendemic trachoma, conjunctival examination was a useful indicator of the prevalence of chlamydial infection before treatments, less useful during mass treatments, but regained utility by one year after treatments had stopped.

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“…Cell-rich smears with suYcient pathogenic material can be examined either by cell culture or by immunoXuorescence test, enzyme immunoassay (EIA) or nucleic acid hybridization test, the latter three of which may be used as quick tests during routine prenatal care. The bacterial load of these specimens is a major factor in diagnosis, which can be deWnitively established only through nucleic acid ampliWcation tests (NAATs) [66]. Vaginal swabs have a lower bacterial load than endocervical swabs, but a higher load than Wrst-void urine (FVU) [20,67].…”

Section: Diagnosismentioning

confidence: 99%

Female genital Chlamydia trachomatis infection: where are we heading?

Mylonas

2012

Arch Gynecol Obstet

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A routine screening for young women and screening during pregnancy is recommended in several countries. However, additional prospective studies of the effectiveness of chlamydia screening are warranted and might be feasible within established screening programs. Moreover, the transition from cervicitis to infertility should be also evaluated in future controlled studies to underline the existing evidence. Additionally, there is an urgent need to educate and inform health-care providers about implementation of screening programs to reduce the spread of chlamydial infection. Moreover, awareness and use of screening programs by the public is needed, which requires informational campaigns for the general public using different media. For improved screening strategies and public awareness, novel approaches have to be developed and evaluated. Finally, guidelines should be actively disseminated to all medical practitioners to increase their use in daily practice. Although the major socioeconomic and public health concerns of C. trachomatis infection are recognized, several considerations and additional measures for addressing this increasingly urgent health problem remain.

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Field evaluation of a rapid point-of-care assay for targeting antibiotic treatment for trachoma control: a comparative study

Cited by 63 publications

References 20 publications

Antibiotic resistance—the need for global solutions

Antibiotic resistance—the need for global solutions

Clinical Activity and Polymerase Chain Reaction Evidence of Chlamydial Infection after Repeated Mass Antibiotic Treatments for Trachoma

Female genital Chlamydia trachomatis infection: where are we heading?

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