Field Observation of Folacin Deficiency in Poults

Lee, C-D; Lv, Belcher; Dl, Miller

doi:10.2307/1588132

Cited by 5 publications

(2 citation statements)

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“…Folate is a potential antioxidant with the capacity for oxyradical scavenging ( 45 ) and is essential for immunity maintenance ( 27 ) , and these attributes would help birds cope with more immunological and oxidative stress during the late period. Furthermore, folate has an important role in poultry viability and growth, and folate insufficiency may affect the survival and growth of poultry ( 46 ) . Therefore, more folate is needed to promote high-intensity growth and overcome more stress in the late stage of broilers.…”

Section: Discussionmentioning

confidence: 99%

Effect of in ovo feeding of folic acid on the folate metabolism, immune function and epigenetic modification of immune effector molecules of broiler

Zhi

et al. 2015

Br J Nutr

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This study was conducted to investigate the effect of in ovo feeding (IOF) of folic acid on the folate metabolism, immune function and the involved epigenetic modification of broilers. A total of 400 (Cobb) hatching eggs were randomly divided into four groups (0, 50, 100 and 150 µg injection of folic acid at embryonic age 11 d), and chicks hatched from each treatment were randomly divided into six replicates with 12 broilers/replicate after incubation. The results indicated that, in ovo, 100-and 150-µg folic acid injections improved the hatchability. The average daily gain and feed conversion ratio increased in the 150-µg group during the late growth stage. Simultaneously, in the 100-and 150-µg groups, an increase was observed in hepatic folate content and the expression of methylenetetrahydrofolate reductase (d1 and 42) and methionine synthase reductase (d21). IgG and IgM concentrations, as well as plasma lysozyme activity of broilers, showed a marked increase along with increasing folic acid levels. The splenic expression levels of IL-2 and IL-4 were up-regulated, whereas that of IL-6 was down-regulated, in the 100-and 150-µg folic acid treatment groups. In addition, histone methylation in IL-2 and IL-4 promoters exhibited an enrichment of H3K4m2 but a loss of H3K9me2 with the increased amount of folic acid additive. In contrast, a decrease in H3K4m2 and an increase in H3K9me2 were observed in the IL-6 promoter in folic acid treatments. Furthermore, in ovo, the 150-µg folic acid injection improved the chromatin tightness of the IL-2 and IL-4 promoter regions. Our findings suggest that IOF of 150 µg of folic acid can improve the growth performance and folate metabolism of broilers, and enhance the relationship between immune function and epigenetic regulation of immune genes, which are involved with the alterations in chromatin conformation and histone methylation in their promoters.

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Section: Discussionmentioning

confidence: 99%

Effect of in ovo feeding of folic acid on the folate metabolism, immune function and epigenetic modification of immune effector molecules of broiler

Zhi

et al. 2015

Br J Nutr

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show abstract

“…Mortality was also lower for poults injected with folacin. Lee et (ca. 1965) were able to correct a folacin defi ciency in poults when they were injected with 150 meg of folacin during the first week after hatching.…”

Section: Introductionmentioning

confidence: 99%