Field Trials of Adjuvant and Saline Influenza Vaccines

Herbert, W.J.; Selwyn, Sydney; Philp, John R.

doi:10.1136/jech.19.2.97

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…5) show that considerably less virus is required to produce a given rise in antibody when oily adjuvant is used. In subsequent adjuvant vaccine trials with a variety of influenza virus strains serological advantages similar to those described above have been obtained with antigen doses 5-10 times lower than those in conventional aqueous vaccines (Davenport, 1961;Hobson et al, 1964;Herbert, Selwyn & Philp, 1965).…”

Section: Discussionmentioning

confidence: 94%

The potential role of immunological adjuvants in influenza vaccines

Hobson

1973

Postgraduate Medical Journal

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Summary Aqueous influenza vaccines seldom induce long-persistent protection against epidemic risk, and often fail to immunize up to one-third of the recipients, especially when there has been no previous immunological experience of the serotype of virus contained in the vaccine. Attempts to improve the situation by increasing the size or number of doses are limited by expense, toxicity and the time available in face of an oncoming epidemic. The future use of isolated viral antigens as vaccines may be limited by similar disadvantages. Immunological adjuvants may make a valuable contribution in decreasing the minimum effective dose of antigen, thereby reducing the toxicity and expense of the vaccine, and increasing its availability. Adjuvant vaccines used in the past have been shown to induce higher mean titres of circulating virus-neutralizing or HI antibody in a higher proportion of the population than have aqueous vaccines, and the duration of immunity has been prolonged. The choice of adjuvants and the avoidance of untoward side-effects are discussed in this review.

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Section: Discussionmentioning

confidence: 94%

The potential role of immunological adjuvants in influenza vaccines

Hobson

1973

Postgraduate Medical Journal

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“…These vaccines induced greater and more sustained antibody responses and enabled antigen sparing [40-42]. However, mineral oil adjuvanted vaccines also induced unwanted local reactions such as cysts and sterile abscesses [43].…”

Section: Recently Introduced Influenza Vaccinesmentioning

confidence: 99%

“…The first generation of adjuvanted influenza vaccines was introduced in the 1950s, and formulations included the emulsification of antigens with mineral oil [ 38 , 39 ]. These vaccines induced greater and more sustained antibody responses and enabled antigen sparing [ 40 - 42 ]. However, mineral oil adjuvanted vaccines also induced unwanted local reactions such as cysts and sterile abscesses [ 43 ].…”

Section: Recently Introduced Influenza Vaccinesmentioning

confidence: 99%

Influenza Vaccines: Unmet Needs and Recent Developments

Noh

2013

Infect Chemother

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Influenza is a worldwide public health concern. Since the introduction of trivalent influenza vaccine in 1978, vaccination has been the primary means of prevention and control of influenza. Current influenza vaccines have moderate efficacy, good safety, and acceptable tolerability; however, they have unsatisfactory efficacy in older adults, are dependent on egg supply for production, and are time-consuming to manufacture. This review outlines the unmet medical needs of current influenza vaccines. Recent developments in influenza vaccines are also described.

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Efficacité comparée de deux techniques de vaccination contre la grippe

Vibes¹

1971

Médecine et Maladies Infectieuses

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Field Trials of Adjuvant and Saline Influenza Vaccines

Cited by 4 publications

References 9 publications

The potential role of immunological adjuvants in influenza vaccines

The potential role of immunological adjuvants in influenza vaccines

Influenza Vaccines: Unmet Needs and Recent Developments

Efficacité comparée de deux techniques de vaccination contre la grippe

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