Objectives: The objective of this study is to identify the clinical characteristics and the factors affecting the morbidity and mortality of the patients with malignancy and to increase the quality of care and raise awareness of rapid targeted-therapy in the emergency department. Materials and Methods: In our study, cancer patients 18 years of age and older who presented to the emergency department of a university hospital were evaluated prospectively. Patients' demographics, vital signs, characteristics associated with malignancy, examinations performed, and their results, treatments, and length of stay were evaluated. Results: A total of 1283 patients and 1522 presentations were recorded. 51.99% of the patients were male, and 48.01% were female. The overall mean age was 63.05±14.08. The most prevalent symptom was dyspnea (17.94%), and the most common type of cancer was lung cancer (16.23%). In male patients, the most prevalent complaint was fever, and the most common type of cancer was lung cancer (34.63%). In female patients, the most prevalent complaint was dyspnea, and the most common type of cancer was breast cancer (35.25%). The influence of MAP, pulse, Hb levels, uremia, and hypoalbuminemia on mortality and ICU admission was significant. Overall, 41.46% of the patients were hospitalized, and 1.05% of the patients died. The average length of stay was 4.64±6.73 days. Conclusion: Patients with malignancy constitute a significant portion of emergency department admissions. Promoting the emergency physicians' insight into and experience on oncological emergencies would contribute to decreasing the mortality and morbidity of these patients. ÖZET Amaç: Çalışmada acil servis başvuran malignite hastalarının klinik karakteristik özelliklerini, morbidite ve mortalitelerine etki eden faktörleri inceleyerek hastaların bakım kalitesini ve hedefe yönelik hızlı tedavi bilincini artırmayı amaçladık.