Fifteen-Year Study of the Changing Epidemiology of Methicillin-Resistant Staphylococcus aureus

Crum, Nancy F.; Lee, Rachel U.; Thornton, Scott A.; Stine, O. Colin; Wallace, Mark R.; Barrozo, Chris; Keefer-Norris, Ananda; Judd, Sharon; Russell, Kevin L.

doi:10.1016/j.amjmed.2006.01.004

Cited by 174 publications

(131 citation statements)

References 39 publications

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“…Staphylococcus aureus is the most commonly isolated pathogen in SSTIs, both in ambulatory and hospitalised patients [14][15][16]. Antimicrobial-resistant pathogens, especially methicillin-resistant S. aureus (MRSA), are increasingly isolated in nosocomial infections [17][18][19][20]. Several recent reports identified MRSA as the leading pathogen in SSTIs [21][22][23][24]; it also causes 20% to 50% of diabetes-associated foot infections in several countries and is associated with worse outcomes than other pathogens [23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost

Tabak²,

et al. 2010

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Aims/hypothesis Skin and soft tissue infections (SSTIs) cause substantial morbidity in persons with diabetes. There are few data on pathogens or risk factors associated with important outcomes in diabetic patients hospitalised with SSTIs. Methods Using a clinical research database from CareFusion, we identified 3,030 hospitalised diabetic patients with positive culture isolates and a diagnosis of SSTI in 97 US hospitals between 2003 and 2007. We classified the culture isolates and analysed their association with the anatomic location of infection, mortality, length of stay and hospital costs. Results The only culture isolate with a significantly increased prevalence was methicillin-resistant Staphylococcus aureus (MRSA); prevalence for infection of the foot was increased from 11.6 to 21.9% (p<0.0001) and for non-foot locations from 14.0% to 24.6% (p=0.006). Patients with non-foot (vs foot) infections were more severely ill at presentation and had higher mortality rates (2.2% vs 1.0%, p<0.05). Significant independent risk factors associated with higher mortality rates included having a polymicrobial culture with Pseudomonas aeruginosa (OR 3

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Section: Introductionmentioning

confidence: 99%

Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost

Tabak²,

et al. 2010

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“…MRSA strains were responsible for 59% of skin and soft tissue infections in 11 U.S. emergency departments, and MRSA made up 59.5% of all S. aureus infections in intensive care unit patients in 2004 (32,37). In addition, the incidence of MRSA disease in the community more than doubled from 2002 to 2004 (14). The increasing rate of MRSA infections has shifted chemotherapy away from ␤-lactam antibiotics and toward drugs effective against MRSA, such as vancomycin.…”

mentioning

confidence: 99%

“…Staphylococcus aureus is an aggressive human pathogen and a leading cause of disease in the community and health care settings (14,32). S. aureus infections range in severity from uncomplicated skin and soft tissue infections to the more severe infections necrotizing pneumonia, endocarditis, and sepsis.…”

mentioning

confidence: 99%

Spontaneous Deletion of the Methicillin Resistance Determinant, mecA , Partially Compensates for the Fitness Cost Associated with High-Level Vancomycin Resistance in Staphylococcus aureus

Noto¹,

Fox²,

Archer

2008

Antimicrob Agents Chemother

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Treatment of infections caused byStaphylococcus aureus is often confounded by the bacterium's ability to develop resistance to chemotherapeutic agents. Methicillin-resistant S. aureus (MRSA) arises through the acquisition of staphylococcal chromosomal cassette mec (SCCmec), a genomic island containing the methicillin resistance determinant, mecA. In contrast, resistance to vancomycin can result from exposure to the drug, a mechanism that is not dependent upon a gene acquisition event. Here we describe three MRSA strains that became resistant to vancomycin during passage in the presence of increasing concentrations of the drug. In each case two derivative strains were isolated, one that had lost mecA and one that retained mecA during passage. Strain 5836VR lost mecA by the site-specific chromosomal excision of SCCmec, while the other two strains (strains 3130VR and VP32) deleted portions of their SCCmec elements in a manner that appeared to involve IS431. Conversion to vancomycin resistance caused a decrease in the growth rate that was partially compensated for by the deletion of mecA. In mixed-culture competition experiments, vancomycin-resistant strains that lacked mecA readily outcompeted their mecA-containing counterparts, suggesting that the loss of mecA during conversion to vancomycin resistance was advantageous to the organism.

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“…lık ile selülit görülmektedir ve lezyonlar genellikle ekstremitelerde yer alır (2,10,11) . Abse ile seyreden olgularda sistemik bulgu olarak ateş yüksekliği ve lökositoz eşlik edebilir (2,10) .…”

Section: S Baysal Ve Ark Toplum Kökenli Metisilin Dirençli Staphylunclassified

“…Abse ile seyreden olgularda sistemik bulgu olarak ateş yüksekliği ve lökositoz eşlik edebilir (2,10) . Hastamızda abse formasyonu gözlenmiş olup, beraberinde ateş ve kan sayı-mında lökositozu da mevcuttu.…”

Section: S Baysal Ve Ark Toplum Kökenli Metisilin Dirençli Staphylunclassified

Abscess cause by community acquired Methicillin Resistant Staphylococcus Aureus

Baysal¹,

Düzgöl²,

Çağlar³

et al. 2016

BUCH

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ÖZToplum kökenli metisilin dirençli Staphylococcus aureus enfeksiyonları, gün geçtikçe sıklığı artmakta olan enfeksiyonlar olup, en sık deri ve yumuşak doku enfeksiyonları olarak karşımıza çıkmaktadır. Bu enfeksiyonlar, çocuklarda sıklıkla abse ve selülit şeklinde prezente olup, hastaların çoğunda risk faktörü olmadan enfeksiyona neden olmuştur. Toplum kökenli Metisilin Dirençli Staphylococcus aureus enfeksiyonları için en önemli virulans faktörü penton valentine lökosidin sentezi kabul edilmektedir ve penton valentine lökosidin pozitif suşların doku nekrozu ve abse formasyonu ile ilişkili olduğu gözlenmiştir. Tedavisinde cerrahi drenaj ve/ve ya antibiyoterapi uygulanmaktadır. Bu makalede, literatür bilgilerinden yararlanılarak Toplum kökenli metisilin dirençli Staphylococcus aureus bağlı deri enfeksiyonu olan bir olgu tartışıl-mıştır.Anahtar kelimeler: toplum kökenli, abse, MRSA ABSTRACTThe incidence of community-acquired Methicillin Resistant Staphylococcus aureus infections (MRSI) is increasing day by day and they most frequently confront us as skin and soft tissue infections. These infections in children frequently present themselves as abscesses and cellulitis and most patients have this infection without known risk factors. The most important virulence factor for the Community-acquired Methicillin Resistant Staphylococcus aureus infections is Penton Valentine Leukocidin synthesis and Penton Valentine Leukocidin positive strains are associated with tissue necrosis and abscess formation. In its treatment, surgical drainage and/or antibiotics are applied. In this article; a patient with skin infections caused by Communityacquired Methicillin Resistant Staphylococcus aureus was discussed by utilizing literature information. Olgu Sunumuİzmir Dr. Behçet Uz Çocuk Hast. Dergisi 2016; 6(3):227-230 doi:10.5222/buchd.2016.227 GİrİŞ Toplum kökenli metisilin dirençli S.aureus enfeksiyonları (TK-MRSA), gün geçtikçe sıklığı artmakta olan enfeksiyonlar olup, en sık deri ve yumuşak doku enfeksiyonları olarak karşımıza çıkmaktadır. Bu enfeksiyonlar, çocuklarda sıklıkla abse ve selülit şeklinde prezente olup, hastaların çoğunda risk faktörü olmadan enfeksiyona neden olmuştur. TK-MRSA enfeksiyonları için en önemli virulans faktörü Penton Valentine Lökosidin (PVL) sentezi kabul edilmektedir ve PVL pozitif suşların doku nekrozu ve abse formasyonu ile ilişkili olduğu gözlenmiştir. Tedavisinde cerrahi drenaj ve/veya antibiyoterapi uygulanmaktadır. Bu makalede literatür bilgilerinden yararlanılarak TK-MRSA bağlı deri enfeksiyonu olan bir olgu tartışılmıştır.

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Fifteen-Year Study of the Changing Epidemiology of Methicillin-Resistant Staphylococcus aureus

Cited by 174 publications

References 39 publications

Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost

Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost

Spontaneous Deletion of the Methicillin Resistance Determinant, mecA , Partially Compensates for the Fitness Cost Associated with High-Level Vancomycin Resistance in Staphylococcus aureus

Abscess cause by community acquired Methicillin Resistant Staphylococcus Aureus

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