Fifty years of multicentric Castleman's disease

A retrospective study of 34�patients with unicentric and multicentric Castleman's disease: Experience from a single institution

“…Abnormalities in the diagnostic examinations, including elevated C-reactive protein expression level and erythrocyte sedimentation rate, were mostly observed in the patients with MCD in the present study, which is consistent with the results of a previous study (3). The radiological characteristics of CD can also be observed in benign or malignant lymphomatous tumors and other mediastinal masses.…”

“…It has been six decades since the discovery of CD by Dr Benjamin Castleman, who described a patient with a solitary hyperplastic mediastinal lymph node in 1954 (1). With the development of clinical examination and imaging technology, numerous previous studies have investigated CD, including the pathophysiology, associated inflammatory mediators and molecular therapies (2,3). Generally, CD can be categorized into two subtypes based on the anatomical distribution of disease: Unicentric CD (UCD) and multicentric CD (MCD).…”

“…Generally, CD can be categorized into two subtypes based on the anatomical distribution of disease: Unicentric CD (UCD) and multicentric CD (MCD). UCD is the most common form, with localized disease and usually being the hyaline vascular histological type (4), whereas MCD is a much more aggressive form with a plasma cell variant pattern histologically (3). Pathological biopsy is required for the diagnosis of CD when a patient presents with lymphadenopathy, as UCD is often asymptomatic and MCD is frequently accompanied by systemic manifestations, including fever, fatigue, edema and weight loss (5).…”

Castleman's Disease: From Basic Mechanisms to Molecular Therapeutics

“…It presents usually later in the fifth to sixth decade of life. MCD can progress to severe pancytopenia, multiorgan failure [6], and lymphoma. It can rarely be associated with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, a devastating disease.…”

A Case of Castleman's Disease Mimicking a Hepatocellular Carcinoma: A Case Report and Review of Literature

“…4,5 In some patients, the presence of multicentric Castleman's disease is associated with polyneuropathy, organomegaly, endocrine abnormality, M-protein, and sclerotic bone lesion (POEMS syndrome). 7,18 Radiologic characteristics of Castleman's disease are quite non-specific. Ultrasonography usually reveals a hypoechogenic and homogenous mass.…”