A Case of Castleman's Disease Mimicking a Hepatocellular Carcinoma: A Case Report and Review of Literature

A Case of Retroperitoneal Castleman’s Disease and an Update on the Latest Evidence

“…Castleman's disease, also known as angiofollicular lymph node hyperplasia, giant lymph node hyperplasia, or lymphoid hamartoma, is a nonclonal, nonneoplastic lymph node proliferation first described by Castleman and Town in 1954. Castleman and Town reported 13 cases of unicentric hyaline vascular lesions of the chest and described the classic pathologic features of hypervascular lymph nodes with hyalinization of vessels, which form concentric arrangements somewhat reminiscent of Hassall corpuscles in the thymus [ 4 – 7 ]. CD has a peak incidence in females on the third and fourth decade of life [ 8 ].…”

“…Histologically, CD consists of three variants: hyaline vascular (HV), plasma cell (PC), or mixed (Mixed). The HV variant is described in 90 per cent of CD cases and is characterized by the proliferation of capillary vessels in germinal centers of lymphatic follicles [ 13 ]; germinal centers are concentrically arranged—in an onion peel-like formation—by a mantle zone of small lymphocytes [ 4 ]. A prominent vascular proliferation is manifested in the interfollicular regions [ 9 ].…”

“…The HV variant is typically associated with the unicentric subtype and often exhibits less clinical manifestations and a benign prognosis. On the other hand, the PC variant is characterized by hyperplastic follicles and an interfollicular region containing sheets of plasma cells; it is often associated with the multicentric subtype, presenting with systemic manifestations, such as fever, malaise, weight loss, fatigue, edema, anemia, hypergammaglobulinemia, organomegaly, and POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes such as erosive lichen planus) [ 4 , 13 , 14 ]. Between 11 per cent and 30 per cent of patients with POEMS syndrome have multicentric CD, most commonly the HHV-8-positive variant [ 7 ].…”

Minimal access surgery in Castleman disease in a child, a case report

“…Earlier reports have described Castleman disease as differential diagnosis to other GI-disease's like pancreatic islet cell tumor [4], Hepatocellular Carcinoma [5], Ulcerative colitis [6], gastric sub-mucosal tumor [7], PSC [8] or in combination with ulcerative colitis [9], Crohn's disease [10], autoimmune pancreatitis [11] or bleeding oesophageal varices [12].…”

Primary Castleman's disease in the liver: A case report and literature review

“…To the best of our knowledge, this finding has not been previously reported in the literature on hepatic CD to date. We hypothesized that the strip-like area may be attributed to lymphoid tissue, and lymphoproliferative disease may develop anywhere where lymphoid tissue is present (20). This strip-like area extending from the nodule may help with the differential diagnosis of hepatic CD from other diseases.…”