Fifty years of progressive supranuclear palsy

Colosimo, Carlo; Bak, Thomas H.; Bologna, Matteo; Berardelli, Alfredo

doi:10.1136/jnnp-2013-305740

Cited by 48 publications

(31 citation statements)

References 94 publications

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“…This drawback is related to the spatial resolution of the blood oxygen level-dependent images, which is insufficient to yield a reliable parcellation. Third, because we studied a homogeneous group of patients affected by Richardson syndrome, 1 and not by other PSP subtypes, the conclusion of our study cannot be extended to other subtypes of PSP. Last, we did not perform a follow-up study; therefore, further investigations are needed to clarify whether FC abnormalities in PSP are useful measures to predict the clinical outcome in this condition.…”

Section: Figmentioning

confidence: 96%

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Disrupted Resting-State Functional Connectivity in Progressive Supranuclear Palsy

Piattella

Tona

Bologna

et al. 2015

AJNR Am J Neuroradiol

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Section: Figmentioning

confidence: 96%

“…All the patients were clinically classified as having Richardson syndrome, one of the subtypes of PSP, 1,14 by experienced neurologists (A.B. and M.B.).…”

Section: Subjectsmentioning

confidence: 99%

Disrupted Resting-State Functional Connectivity in Progressive Supranuclear Palsy

Piattella

Tona

Bologna

et al. 2015

AJNR Am J Neuroradiol

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“…Motor symptoms include parkinsonian signs, postural instability with frequent falls and ocular motor abnormalities. Non-motor symptoms consist of cognitive and behavioral abnormalities, including impairment of executive functions, subcortical dementia, and personality changes [1,2]. From a pathological point of view, PSP is characterized by neuronal and glial depositions of an abnormally phosphorylated tau protein in the basal ganglia nuclei, diencephalon, brainstem, and cerebellum, with limited involvement of the neocortex [3].…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging evidence of gray and white matter damage and clinical correlates in progressive supranuclear palsy

et al. 2015

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To evaluate gray matter (GM) and white matter (WM) abnormalities and their clinical correlates in patients with progressive supranuclear palsy (PSP). Sixteen PSP patients and sixteen age-matched healthy subjects underwent a clinical evaluation and multimodal magnetic resonance imaging, including three-dimensional T1-weighted imaging and diffusion tensor imaging (DTI). Volumetric and DTI analyses were computed using SPM and FSL tools. PSP patients showed GM volume decrease, involving the frontal cortex, putamen, pallidum, thalamus and accumbens nucleus, cerebellum, and brainstem. Additionally, they had widespread changes in WM bundles, mainly affecting cerebellar peduncles, thalamic radiations, corticospinal tracts, corpus callosum, and longitudinal fasciculi. GM volumes did not correlate with WM abnormalities. DTI indices of WM damage, but not GM volumes, correlated with clinical scores of disease severity and cognitive impairment. The neurodegenerative changes that occur in PSP involve both GM and WM structures and develop concurrently though independently. WM damage in PSP correlates with clinical scores of disease severity and cognitive impairment, thus providing further insight into the pathophysiology of the disease.

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“…It has been mentioned in its first descriptions [1] and forms part of the most diagnostic criteria [2,3]. It is one of the important features distinguishing it from progressive supranuclear palsy (PSP): a syndrome to which it is closely related clinically as well as pathologically [4].…”

Section: Introductionmentioning

confidence: 99%

The association of aphasia and right-sided motor impairment in corticobasal syndrome

et al. 2015

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Corticobasal syndrome is defined clinically on the basis of symptoms and findings related to dysfunction of the cerebral cortex and the basal ganglia. Usually, marked asymmetry of motor findings is observed. Although aphasia has now been recognized as a frequent feature of corticobasal syndrome, it remains unclear whether it is usually associated with right-sided motor symptoms, pointing to the involvement of the left hemisphere. Hence, we set out to examine the relationship between the presence of language symptoms and the side affected by extrapyramidal symptoms. We analyzed the electronic care records of patients seen in the years 2003-2013 in the Neurology Department of the University Hospital of Munich. The diagnosis of corticobasal syndrome was discussed in ninety-two individuals. Of those, 38 cases fulfilled diagnostic criteria for corticobasal syndrome. Aphasia correlated highly with a predominant right-sided movement disorder (p = 0.002). In contrast, it was less common in patients with left-sided motor presentation. Dysarthria did not show a preferential correlation (p = 0.25). Our analysis suggests a characteristic presentation of corticobasal syndrome in which motor dysfunction of the right side of the body is associated with aphasia.

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Fifty years of progressive supranuclear palsy

Abstract: [No abstract available

Cited by 48 publications

References 94 publications

Disrupted Resting-State Functional Connectivity in Progressive Supranuclear Palsy

Disrupted Resting-State Functional Connectivity in Progressive Supranuclear Palsy

Neuroimaging evidence of gray and white matter damage and clinical correlates in progressive supranuclear palsy

The association of aphasia and right-sided motor impairment in corticobasal syndrome

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