Fight Against COVID-19: ARCI’s Technologies for Disinfection

Sarada, Bulusu V.; Vijay, Ritu; Johnson, Rebecca; Rao, Tata N.; Padmanabham, G.

doi:10.1007/s41403-020-00153-3

Cited by 34 publications

(21 citation statements)

References 17 publications

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“… Ludwig-Begall et al (2020) studied three techniques of decontaminating face masks: (1) ultraviolet germicidal irradiation, (2) vaporized hydrogen peroxide and (3) dry heat ( Ludwig-Begall et al, 2020 ). Sarada et al (2020) described the technologies of the International Advanced Research Center for Powder Metallurgy and New Materials (ARCI), India, in developing various disinfection systems to combat COVID-19 ( Sarada et al, 2020 ). ARCI used physical, chemical and dry heat processes to disinfect surfaces effectively.…”

Section: Introductionmentioning

confidence: 99%

Performance study of a sterilization box using a combination of heat and ultraviolet light irradiation for the prevention of COVID-19

Mahanta

Saxena

Pandey

et al. 2021

Environmental Research

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SARS-CoV-2 virus and other pathogenic microbes are transmitted to the environment through contacting surfaces, which need to be sterilized for the prevention of COVID-19 and related diseases. In this study, a prototype of a cost-effective sterilization box is developed to disinfect small items. The box utilizes ultra violet (UV) radiation with heat. For performance assessment, two studies were performed. First, IgG (glycoprotein, a model protein similar to that of spike glycoprotein of SARS-COV-2) was incubated under UV and heat sterilization. An incubation with UV at 70 °C for 15 minutes was found to be effective in unfolding and aggregation of the protein. At optimized condition, the hydrodynamic size of the protein increased to ∼171 nm from ∼5 nm of the native protein. Similarly, the OD 280 values also increased from 0.17 to 0.78 indicating the exposure of more aromatic moieties and unfolding of the protein. The unfolding and aggregation of the protein were further confirmed by the intrinsic fluorescence measurement and FTIR studies, showing a 70% increase in the β-sheets and a 22 % decrease in the α-helixes of the protein. The designed box was effective in damaging the protein’s native structure indicating the effective inactivation of the SARS-COV-2. Furthermore, the incubation at 70 °C for 15 minutes inside the chamber resulted in 100 % antibacterial efficacy for the clinically relevant E.coli bacteria as well as for bacteria collected from daily use items. It is the first detailed performance study on the efficacy of using UV irradiation and heat together for disinfection from virus and bacteria.

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Section: Introductionmentioning

confidence: 99%

Performance study of a sterilization box using a combination of heat and ultraviolet light irradiation for the prevention of COVID-19

Mahanta

Saxena

Pandey

et al. 2021

Environmental Research

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“…The precise timing, the location, and the mechanism of disinfection, the type of disinfectant to be used, and safety measures to be implemented for both public health and the environment must be determined (Iyiola et al 2020 ; Nabi et al 2020 ; Zhang et al 2020 ). Determination of the minimum amount of disinfectant necessary, appropriate exposure levels, and appropriate level of contact is essential for optimum action (Sarada et al 2020 ). Avoidance of indiscriminate sprays, minimization of public movement, and the development of low-risk or nontoxic but effective disinfectants for future safe applications should be an international priority (Iyiola et al 2020 ; Nabi et al 2020 ; Zhang et al 2020 ).…”

Section: Updated Disinfection Approaches Against Sars-cov-2mentioning

confidence: 99%

“…Avoidance of indiscriminate sprays, minimization of public movement, and the development of low-risk or nontoxic but effective disinfectants for future safe applications should be an international priority (Iyiola et al 2020 ; Nabi et al 2020 ; Zhang et al 2020 ). Additionally, efforts should be engaged for the development of disinfection systems, such as UVC-based disinfection trolleys, UVC germicidal lamp-based fogging chambers, dry heat sterilization, and HOCl-based chemical disinfectants (Sarada et al 2020 ).…”

Section: Updated Disinfection Approaches Against Sars-cov-2mentioning

confidence: 99%

The role of disinfectants and sanitizers during COVID-19 pandemic: advantages and deleterious effects on humans and the environment

Dhama

Patel

Kumar

et al. 2021

Environ Sci Pollut Res

150

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Disinfectants and sanitizers are essential preventive agents against the coronavirus disease 2019 (COVID-19) pandemic; however, the pandemic crisis was marred by undue hype, which led to the indiscriminate use of disinfectants and sanitizers. Despite demonstrating a beneficial role in the control and prevention of COVID-19, there are crucial concerns regarding the large-scale use of disinfectants and sanitizers, including the side effects on human and animal health along with harmful impacts exerted on the environment and ecological balance. This article discusses the roles of disinfectants and sanitizers in the control and prevention of the current pandemic and highlights updated disinfection techniques against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This article provides evidence of the deleterious effects of disinfectants and sanitizers exerted on humans, animals, and the environment as well as suggests mitigation strategies to reduce these effects. Additionally, potential technologies and approaches for the reduction of these effects and the development of safe, affordable, and effective disinfectants are discussed, particularly, eco-friendly technologies using nanotechnology and nanomedicine.

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“…EW at HOCl concentration of 200 ppm is effective in inactivating a variety of viruses, including coronaviruses, noroviruses, and other enteric viruses (15). Recent studies (4,15,23) reported the effectiveness of EW with HOCl concentrations as low as 100 ppm against SARS-CoV-2, and many HOCl-based products have been developed that meet the EPA criteria for use against SARS-CoV-2 (5). Moreover, previous studies (24,25) showed that slightly acidic EW and neutral EW generated in single-cell units (without diaphragm), similar to that mentioned in this report, were effective against difficult-to-kill viruses/pathogens (such as non-enveloped viruses (e.g., norovirus) (26).…”

Section: Reportmentioning

confidence: 99%

Electrolyzed Water Generated On-Site as a Promising Disinfectant in the Dental Office During the COVID-19 Pandemic

Farah

Ali

2021

Front. Public Health

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Electrolyzed water is a safe, broad-spectrum bactericidal and viricidal agent, which can be used as a potent and effective alternative disinfectant in case of supply shortages. This report describes the on-site production of slightly acidic electrolyzed water (EW) from diluted salt solution and vinegar at a dental office using a portable EW generator unit. Such measures can ensure the safe continuity of important dental service provision for our patients during the coronavirus disease 2019 (CoVID-19) pandemic.

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Fight Against COVID-19: ARCI’s Technologies for Disinfection

Cited by 34 publications

References 17 publications

Performance study of a sterilization box using a combination of heat and ultraviolet light irradiation for the prevention of COVID-19

Performance study of a sterilization box using a combination of heat and ultraviolet light irradiation for the prevention of COVID-19

The role of disinfectants and sanitizers during COVID-19 pandemic: advantages and deleterious effects on humans and the environment

Electrolyzed Water Generated On-Site as a Promising Disinfectant in the Dental Office During the COVID-19 Pandemic

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