Fighting Food Allergy by Inducing Oral Tolerance: Facts and Fiction

Yang, Xiaotong; Liang, Rui; Xing, Qianlu; Ma, Xiaojuan

doi:10.1159/000515292

Cited by 9 publications

(4 citation statements)

References 120 publications

(128 reference statements)

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“…A mother's distress while breastfeeding can alter milk microbiota ( 33 ) or lower milk secretory immunoglobulin A ( 34 ), both of which affect infant gut immunity ( 35 ). Hence, impaired mother-infant feeding or social interactions may lower socio-emotional responses in the infant ( 36 ) and, via the gut-brain axis, lead to food intolerance ( 37 ). Since parent-child interactions, namely strategies for infant soothing, were not assessed in our study, we are unable to offer explanations for the unexpected findings on food sensitization and improved cognition or language in boys.…”

Section: Discussionmentioning

confidence: 99%

Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment

Tessier¹,

Mandhane²,

Pei³

et al. 2022

Front. Pediatr.

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IntroductionFood sensitization is a first and strong indicator of immune deviation in the progression to other allergic conditions. Sensitization to food or other allergens and related inflammation during critical windows of infant development may adversely affect neurodevelopmental milestones. However, additional research is needed to test this association further.MethodsAssociations between atopic (any food or aeroallergen) or food sensitization (specific to egg, soybean, peanut, and milk) at age 1 year and neurodevelopment up to 2 years of age were evaluated in the national CHILD Cohort Study, with a secondary aim examining whether these associations were sex-specific. Food and atopic sensitization were assessed by skin prick tests (SPT) in 1-year-old infants, with neurodevelopment assessed using the cognitive, language, motor, and social-emotional subscales of the Bayley Scales of Infant Development (BSID-III) administered at 1 and 2 years of age.ResultsAtopic sensitization was present among 16.4% of infants, while 13.4% had food sensitizations. Only socioemotional scores reached statistical significance among the four BSID-III domains. Both atopic and food sensitization at 1 year of age was associated with lower social-emotional scores, independent of the infant's ethnicity. These findings were sex-specific and only observed among boys, among whom social-emotional scores were lowered by 5 points if atopic sensitization was present (−5.22 [95% CI: −9.96, −0.47], p = 0.03) or if food sensitization was present (−4.85 [95% CI: −9.82,0.11], p = 0.06). Similar results were observed using the standard SPT cut-off of ≥3 mm — for atopic sensitization (−5.17 [95% CI: −11.14, −0.80], p = 0.09) and for food sensitization (−4.61 [95% CI: −10.96, 1.74], p = 0.15).ConclusionIn our study of term infants, we found an inverse, cross-sectional association between atopic and food sensitization status and social-emotional development scores in male children but not female children.

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Section: Discussionmentioning

confidence: 99%

Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment

Tessier¹,

Mandhane²,

Pei³

et al. 2022

Front. Pediatr.

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“…Allergic enterocolitis with food allergies is characterized by severe pain in the abdomen, flatulence, and loose stools with the discharge of vitreous mucus, which contains many eosinophils. Patients with allergic enterocolitis complain of extreme weakness, loss of appetite, headache, and dizziness (9,12,13,73). Histological examination of patients with allergic enterocolitis reveals hemorrhagic changes, pronounced tissue eosinophilia, local edema, and mucus hypersecretion (7,9,68,72,81,84,85).…”

Section: Gastrointestinal Manifestationsmentioning

confidence: 99%

Enterosorbents in complex therapy of food allergies: a focus on digestive disorders and systemic toxicity in children

Shichkin,

Kurchenko,

Okhotnikova

et al. 2023

Front. Immunol.

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The review analyzes mechanisms and concomitant factors in developing IgE-associated allergic diseases provoked by food allergens and discusses clinical symptoms and current approaches for the treatment of food allergies. The expediency of using enterosorbents in complex therapy of food allergies and skin and respiratory manifestations associated with gastroenterological disorders is substantiated. The review summarizes the experience of using enterosorbents in post-Soviet countries to detoxify the human body. In this regard, special attention is paid to the enterosorbent White Coal (Carbowhite) based on silicon dioxide produced by the Ukrainian company OmniFarma.

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“…The default, "healthy" reaction of the immune system to food proteins is called oral tolerance, which is the continuous unresponsiveness of the immune system to the 130-190 g of food proteins daily absorbed, a process that is largely mediated by the gut-associated lymphoid tissue (GALT) (Brandtzaeg, 2009;Yang et al, 2021). GALT is the largest lymphoid tissue in the body, comprising among others the Peyer's patches, the lymphoid follicles, and the mesenteric lymph node (MLN).…”

Section: Loss Of Oral Tolerancementioning

confidence: 99%

Critical features of an in vitro intestinal absorption model to study the first key aspects underlying food allergen sensitization

Dijk

Villa

Benedé

et al. 2022

Comp Rev Food Sci Food Safe

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New types of protein sources will enter our diet in a near future, reinforcing the need for a straightforward in vitro (cell‐based) screening model to test and predict the safety of these novel proteins, in particular their potential risk for de novo allergic sensitization. The Adverse Outcome Pathway (AOP) for allergen sensitization describes the current knowledge of key events underlying the complex cellular interactions that proceed allergic food sensitization. Currently, there is no consensus on the in vitro model to study the intestinal translocation of proteins as well as the epithelial activation, which comprise the first molecular initiation events (ME1‐3) and the first key event of the AOP, respectively. As members of INFOGEST, we have highlighted several critical features that should be considered for any proposed in vitro model to study epithelial protein transport in the context of allergic sensitization. In addition, we defined which intestinal cell types are indispensable in a consensus model of the first steps of the AOP, and which cell types are optional or desired when there is the possibility to create a more complex cell model. A model of these first key aspects of the AOP can be used to study the gut epithelial translocation behavior of known hypo‐ and hyperallergens, juxtaposed to the transport behavior of novel proteins as a first screen for risk management of dietary proteins. Indeed, this disquisition forms a basis for the development of a future consensus model of the allergic sensitization cascade, comprising also the other key events (KE2‐5).

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Fighting Food Allergy by Inducing Oral Tolerance: Facts and Fiction

Cited by 9 publications

References 120 publications

Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment

Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment

Enterosorbents in complex therapy of food allergies: a focus on digestive disorders and systemic toxicity in children

Critical features of an in vitro intestinal absorption model to study the first key aspects underlying food allergen sensitization

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