Filbertone Ameliorates Adiposity in Mice Fed a High-Fat Diet via Activation of cAMP Signaling

Moon, Youna; Tong, Teng; Kang, Won Jun; Park, Tae Sun

doi:10.3390/nu11081749

Cited by 16 publications

(14 citation statements)

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“…[56] The cAMP signaling pathway is thus pivotal in regulation of adipose tissue development and function, and it has become a therapeutic target of certain antiobesity phytochemicals. For example, Moon et al [4] reported that filbertone, a major flavor compound in the fruits of hazel trees, reduced lipid accumulation in HFD-fed mice and 3T3-L1 cells by activating the cAMP pathway. Taken together, the transcriptome analysis suggested that EU significantly changed metabolism and signal pathways in epididymal WAT under high-fat feeding conditions.…”

Section: Discussionmentioning

confidence: 99%

“…For example, high-fat diet (HFD) overconsumption is one of the leading causes of obesity. [3,4] In addition, the obesity pandemic is associated with the increasing prevalence of various other chronic diseases and infectious disease, such as type 2 diabetes mellitus, cardiovascular diseases, hypertension, and corona virus disease 2019, and therefore confers serious global public health issues. [5,6] The worldwide prevalence of obesity nearly tripled between 1975 and 2016 in accordance with the World Health Organization, and in 2016, overweight and obese people account for around 39% and 13% of the world's adult population, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Eugenol, A Major Component of Clove Oil, Attenuates Adiposity, and Modulates Gut Microbiota in High‐Fat Diet‐Fed Mice

Zhao

Wang

et al. 2022

Molecular Nutrition Food Res

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Scope Eugenol (EU), the major aromatic compound derived from clove oil, is being focused recently due to its potential in preventing several chronic conditions. Herein, this study aims to evaluate the potential of EU in obesity prevention and to delineate the mechanisms involved. Methods and results Five‐week‐old male C57BL/6J mice are fed with high‐fat diet (HFD) or HFD supplemented with EU (0.2%, w/w) for 13 weeks. EU significantly reduces obesity‐related indexes including final body weight, body weight gain, adipocyte size, visceral fat‐pad weight, and fasting blood glucose. EU prevents HFD‐induced gut dysbiosis, as indicated by the increase of Firmicutes and decrease of Desulfobacterota at phylum level, and the increase of Dubosiella, Blautia, unclassified_f_Oscillospiraceae, and unclassified_f_Ruminococcaceae, and the decrease of Alistipes, Alloprevotella, and Bilophila at genus level. Notably, the obesity‐related indexes are positively correlated with the relative abundances of Bacteroides, unclassified_f_Lachnospiraceae, Colidextribacter, and Bilophila, and negatively correlated with the relative abundances of norank_f_Muribaculaceae and Lachnospiraceae_NK4A136_group. Moreover, the preventive effects of EU on obesity are accompanied by the transcriptomic reprogramming of white adipose tissue. Conclusion These findings demonstrate that EU prevents the HFD‐induced adiposity and modulates gut dysbiosis, and highlight the potential of EU in obesity intervention as a functional dietary supplement.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eugenol, A Major Component of Clove Oil, Attenuates Adiposity, and Modulates Gut Microbiota in High‐Fat Diet‐Fed Mice

Zhao

Wang

et al. 2022

Molecular Nutrition Food Res

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“…C/EBP-α is a central transcriptional adipogenic activator regulated by cAMP-responsive element-binding protein (CREB). cAMP binds to the regulatory subunit PKA and release the catalytic subunit; it phosphorylates the lipid metabolism-associated protein substrates, including AMPK, in peripheral and subcutaneous adipocytes ( Moon et al, 2019 ). AMPK activated during depletion of the cellular ATP increases the AMP/ATP ratio and initiates metabolic and genetic events to restore ATP levels via fatty acid beta-oxidation in adipocytes ( Cheng et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Biosafety, Antiobesity, and Endothelial Cells Proliferation Potential of Basil Seed Extract Loaded Organic Solid Lipid Nanoparticle

et al. 2021

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The present study aimed to synthesize solid lipid nanoparticles to enhance liposome-assisted intracellular uptake of basil seed active components in adipocytes and vascular smooth muscle cells to attain increased bioavailability. To obtain solid lipid nanoparticle (SLNp), the water phase containing basil seed extract (BSE) was encapsulated with lipid matrix containing chia seed phospholipids using homogenization and cold ultra-sonication method. The physicochemical characterization of BSE loaded solid lipid nanoparticles (BSE-SLNp) has been analyzed using Zetasizer, FT-IR, and TEM. The BSE-SLNp showed an average diameter of 20–110 nm on the day of preparation and it remains the same after 60 days of storage. The cytotoxicity assay confirmed that the BSE-SLNp did not produce toxicity in hMSCs, preadipocytes, or human umbilical vein endothelial cells (HUVECs) until the tested higher dose up to 64 μg/ml. During effective dose determination, 4 μg/ml of BSE-SLNp confirmed non-toxic and enhanced metabolic function in hMSCs, preadipocytes, and HUVECs. Biosafety assay confirmed normal nuclear morphology in PI staining and high mitochondrial membrane potential in JC-1 assay within 48 h in hMSCs. The maturing adipocyte treated with 4 μg/ml of BSE-SLNp significantly increased the mitochondrial efficiency and fatty acid beta-oxidation (PPARγC1α, UCP-1, and PRDM-16) related gene expression levels. Oxidative stress induced HUVECs treated with 4 μg/ml of BSE-SLNp potentially enhanced antioxidant capacity, cell growth, and microtubule development within 48 h H2O2 induced oxidative stressed HUVECs have shown 39.8% viable cells, but treatment with BSE-SLNp has shown 99% of viable cells within 48 h confirmed by Annexin-V assay. In addition, mitochondrial membrane potential (Δψm) increased to 89.4% confirmed by JC-1 assay. The observed DNA integrity, cell viability was confirmed by increased antioxidant and tumor suppressor-related gene expression levels. VEGF expression has been significantly increased and pro-inflammation-related mRNA levels were decreased in BSE-SLNp treated cells. In conclusion, enhanced adipocyte fatty acid oxidation is directly associated with decreased adipocytokine secretion which arrests obesity-associated comorbidities. In addition, suppressing vascular cell oxidative stress and metabolic inflammation supports vascular cell proliferation and arrests ageing-related vascular diseases.

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“…Piperonal, an aromatic compound found in vanilla and filbertone, the main flavor compound in hazelnuts, increases the level of cAMP in adipose tissue, decreases the body weight and plasma lipid profiles, and improves glucose tolerance in HFD-induced obese mice [ 105 , 106 , 107 ]. Obesity is well-known to contribute to the progression and development of diabetes.…”

Section: Adipose Tissuementioning

confidence: 99%

Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

Wang

Liu²,

Kang

et al. 2021

Nutrients

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As the prevalence of diabetes increases progressively, research to develop new therapeutic approaches and the search for more bioactive compounds are attracting more attention. Over the past decades, studies have suggested that cyclic adenosine monophosphate (cAMP), the important intracellular second messenger, is a key regulator of metabolism and glucose homeostasis in diverse physiopathological states in multiple organs including the pancreas, liver, gut, skeletal muscle, adipose tissues, brain, and kidney. The multiple characteristics of dietary compounds and their favorable influence on diabetes pathogenesis, as well as their intersections with the cAMP signaling pathway, indicate that these compounds have a beneficial effect on the regulation of glucose homeostasis. In this review, we outline the current understanding of the diverse functions of cAMP in different organs involved in glucose homeostasis and show that a diversity of bioactive ingredients from foods activate or inhibit cAMP signaling, resulting in the improvement of the diabetic pathophysiological process. It aims to highlight the diabetes-preventative or -therapeutic potential of dietary bioactive ingredients targeting cAMP signaling.

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Filbertone Ameliorates Adiposity in Mice Fed a High-Fat Diet via Activation of cAMP Signaling

Cited by 16 publications

References 34 publications

Eugenol, A Major Component of Clove Oil, Attenuates Adiposity, and Modulates Gut Microbiota in High‐Fat Diet‐Fed Mice

Eugenol, A Major Component of Clove Oil, Attenuates Adiposity, and Modulates Gut Microbiota in High‐Fat Diet‐Fed Mice

Evaluation of Biosafety, Antiobesity, and Endothelial Cells Proliferation Potential of Basil Seed Extract Loaded Organic Solid Lipid Nanoparticle

Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment

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