2008
DOI: 10.1002/jbm.b.31190
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Filler particles used in dental biomaterials induce production and release of inflammatory mediators in vitro

Abstract: Although dental composites are in extensive use today, little is known about the biological effects of the filler particles. As composite materials are gradually broken down in the aggressive environment of the oral cavity, the filler particles may leak and induce toxic effects on the surrounding tissue and cells. The aim of this study was to elucidate possible adverse biological effects of commonly used dental filler particles; bariumaluminiumsilica (BaAlSi) and bariumaluminiumfluorosilica (BaAlFSi) with mean… Show more

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Cited by 12 publications
(7 citation statements)
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“…Although some of the resin composites include the same monomers as declared, ROS production and cell viability changes were found to be distinct, as reported previously for different dentin bonding agents [12]. These findings are consistent with previous studies showing that the cytotoxic effect depends not only on the monomers and co-monomers, but also reactions between the components, degradation by products, additives and fillers, which all elicit cytotoxic and inflammatory responses to various degrees [16][17][18].…”
Section: Discussionsupporting
confidence: 90%
“…Although some of the resin composites include the same monomers as declared, ROS production and cell viability changes were found to be distinct, as reported previously for different dentin bonding agents [12]. These findings are consistent with previous studies showing that the cytotoxic effect depends not only on the monomers and co-monomers, but also reactions between the components, degradation by products, additives and fillers, which all elicit cytotoxic and inflammatory responses to various degrees [16][17][18].…”
Section: Discussionsupporting
confidence: 90%
“…induction of inflammatory cytokines and chemokines in cells was demonstrated (Ansteinsson et al, 2009). Another study used a micromanipulation technique to examine various representative fillers used in dental composites.…”
Section: New Analytical Approaches Applied To Filled Materialsmentioning
confidence: 99%
“…The filler loading and the presence of nanofiller were found to alter the viscoelastic behavior of the composite materials as well as macrophage cell adhesion, although variations in the methacrylate conversion produced the most significant differences. Related to this issue, filler particle induction of inflammatory cytokines and chemokines in cells was demonstrated (Ansteinsson et al ., 2009). Another study used a micromanipulation technique to examine various representative fillers used in dental composites.…”
Section: Fillers and Filler Modificationsmentioning
confidence: 99%
“…[7] The biocompatibility of dental restorative materials is being evaluated in different test settings. [8] Red blood cells (RBCs) and associated materials have been elucidated with respect to effect on cellular and sub-cellular levels related to resin constituents [9][10][11] and also filler particles [12] [ Figure 1]. latex gloves, impression materials, eugenol containing temporary cements.…”
Section: Introductionmentioning
confidence: 99%