The dynamic structure of the ionosphere and its changes play an important role in comprehending the natural cycle by linking earth sciences and space sciences. Ionosphere research includes a variety of fields like meteorology, radio wave reflection from the atmosphere, atmospheric anomaly detection, the impact on GNSS (Global Navigation Satellite Systems) signals, the exploration of earthquake precursors, and the formation of the northern lights. To gain further insight into this layer and to monitor variations in the total electron content (TEC), ionospheric maps are created using a variety of data sources, including satellite sensors, GNSS data, and ionosonde data. In these maps, data deficiencies are addressed by using interpolation methods. The objective of this study was to obtain high-accuracy VTEC (Vertical Total Electron Content) information to analyze TEC anomalies as precursors to earthquakes. We propose an innovative approach: employing alternative mathematical surfaces for VTEC calculations, leading to enhanced change analytical interpretation for anomaly detections. Within the scope of the application, the second-degree polynomial method, kriging (point and block model), the radial basis multiquadric, and the thin plate spline (TPS) methods were implemented as interpolation methods. During a 49-day period, the TEC values were computed at three different IGS stations, generating 1176 hourly grids for each interpolation model. As reference data, the ionospheric maps produced by the CODE (Center for Orbit Determination in Europe) Analysis Center were used. This study’s findings showed that, based on statistical values, the TPS model offered more accurate results than other methods. Additionally, it has been observed that the peak values in TEC calculations based on polynomial surfaces are eliminated in TPSs.