Film-Forming Polymers for Tooth Erosion Prevention

Augusto, Marina Gullo; Scaramucci, Taís; Campos, Tiago Moreira Bastos; Aoki, Idalina Vieira; Schlueter, Nadine; Borges, Alessandra Bühler

doi:10.3390/polym14194225

Cited by 4 publications

(1 citation statement)

References 96 publications

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“…The following 5 polymers were tested: Acrylic acid crosslinked with allyl sucrose or allyl pentaerythritol (Polyacrylic acid -PA, Carbopol 980, Noveon, Cleveland, USA), Chitosan 80/500 (Chitosan, Heppe Medical Chitosan GmbH, Halle, Germany), Sodium linear polyphosphate (LPP, Merck Millipore, Darmstadt, Germany), Gantrez MS-955 (Poly methyl/vinyl/ether and maleic anhydride -PVM/MA, Ashland Specialty Ingredients, Ashland, USA), and Propylene glycol alginate (PGA, Sidley Chemical Co., Linyi, Shandong, China). The solutions were prepared with 3 different concentrations of polymers (1 g/L, 3 g/L, and 5 g/L) [Augusto et al, 2022] and with 2 pHs (native pH and adjusted pH to 4.5), in order to find the condition with the best potential for modifying the pellicle for protection against dental erosion. The pH of 4.5 was chosen because it is the value commonly found in some commercially available mouth rinses [Grandizoli et al, 2022].…”

Section: Test Solutionsmentioning

confidence: 99%

Film-Forming Polymers for Inhibition of Hydroxyapatite Dissolution: A Screening Study

Sakae,

Prado,

Bezerra

et al. 2023

Caries Res

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The aim of this study was to evaluate the effect of film-forming polymer solutions of different concentrations and pH values, either associated or not with sodium fluoride (F; 225 ppm F-), when applied during the initial stage of salivary pellicle formation, to prevent the dissolution of hydroxyapatite (HA), which was determined by the pH-stat method. Polyacrylic acid (PA), Chitosan, Sodium linear polyphosphate (LPP), Polyvinyl methyl ether/maleic anhydride (PVM/MA) and Propylene glycol alginate (PGA) were tested in three concentrations (lower, medium, higher), two pH values (native or adjusted) and either associated or not with F. Distilled water, F and stannous ion+fluoride (Sn/F; 225 ppm F- and 800 ppm Sn2+, as SnCl2) solutions were the controls, totalizing 63 groups. Hydroxyapatite crystals were pre-treated with human saliva for 1 min to allow pellicle formation, then immersed in the experimental solutions (1 min), and exposed to saliva for another 28 min. Subsequently they were added to a 0.3% citric acid solution (pH=3.8), connected to a pH-stat system that added aliquots of 28 μl 0.1 N HCl for a total reaction time of 5 min. Data were analyzed with one-way ANOVA and Tukey’s tests (α=0.05). For PA alone, the concentrations of 0.1% (native pH), 0.06% and 0.08% (both pH adjusted) showed significantly lower HA dissolution than the negative control. PA concentrations of 0.1% and 0.08%, of both pH values, improved the effect of F against HA dissolution to a near-identical value as Sn/F. All solutions containing Chitosan and LPP significantly reduced HA dissolution in comparison with the control. For Chitosan, the concentration of 0.5% (in both pH values) improved the effect of F. LPP at 0.5% (native pH) and all associations of LPP with F outperformed the effect of F. Some PVM/MA solutions significantly reduced HA dissolution, but PVM/MA could not improve the protection of F. PGA was incapable of reducing HA dissolution, or improving F effect. It was concluded that Chitosan, LPP and some PA and PVM/MA solutions used alone, were capable of reducing HA dissolution. Only PA, Chitosan and LPP were able to enhance fluoride protection, but for PA and Chitosan, this was influenced by the polymer concentration.

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Section: Test Solutionsmentioning

confidence: 99%

Film-Forming Polymers for Inhibition of Hydroxyapatite Dissolution: A Screening Study

Sakae,

Prado,

Bezerra

et al. 2023

Caries Res

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Effect of combining aminomethacrylate and fluoride against erosive and abrasive challenges on enamel and dentin

Augusto,

da Silva,

Lotto

et al. 2024

European J Oral Sciences

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This study evaluated the effect of solutions containing aminomethacrylate copolymer (AA) and sodium fluoride (F; 225 ppm F−) or fluoride plus stannous chloride (FSn; 225 ppm F−, 800 ppm Sn2+) against enamel and dentin erosion/abrasion. Solutions F, FSn, AA, F+AA, FSn+AA, and deionized water as negative control were tested. Bovine enamel and dentin specimens (n = 13/solution/substrate) underwent a set of erosion‐abrasion cycles (0.3% citric acid [5 min, 4×/day], human saliva [1 h, 4×/day], brushing [15 s, 2×/day], and treatments [2 min, 2×/day]) for each of five days. Initial enamel erosion was evaluated using Knoop microhardness after the first and second acid challenge on day 1, and surface loss with profilometry after day 5. KOH‐soluble fluoride was assessed. Data were analyzed with ANOVA/Tukey tests. The combination of fluoride and AA resulted in higher protection against enamel erosion, whereas this was not the case for the combination of AA and FSn. All treatments protected against enamel and dentin loss. The lowest surface loss values were observed with F+AA and FSn+AA. The polymer did not significantly influence the KOH‐soluble fluoride formation on enamel/dentin specimens. The aminomethacrylate copolymer effectively enhanced the efficacy of sodium fluoride against initial erosion and improved the control of enamel and dentin wear of F and FSn solutions.

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Effect of a 1.1% NaF toothpaste containing Sr/F-doped bioactive glass on irradiated demineralized dentin: an in vitro study

Gesprasert,

Kettratad,

Nimmano

et al. 2024

BMC Oral Health

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Objective Patients receiving head and neck radiation are at high risk for radiation caries. This study aimed to evaluate the remineralizing effects of an experimental 1.1% NaF (5000 ppmF) toothpaste containing Sr/F-doped bioactive glass nanoparticles (BAG or B) on demineralized irradiated dentin. Materials and methods Fluoride concentration and pH stability of materials upon mixing with water were assessed using a fluoride-specific electrode ( n = 3) for up to 3 months. Elemental release of materials in water was determined using ICP-OES ( n = 3). Fourteen extracted molars were irradiated with a cumulative dose of 70 Gy. Each tooth was sectioned into 4 specimens ( n = 14/group), demineralized, and subjected to pH cycling for 14 days. Groups were treated with Prevident (PV), E5000, E5000B, and deionized water twice daily. Remineralization was assessed using ATR-FTIR (mineral-to-collagen ratio) ( n = 14). Mineral precipitation was additionally examined with SEM-EDX. The in vitro cytotoxicity of the materials on L929 mouse fibrosarcoma was evaluated with the MTT test ( n = 3). Kruskal-Wallis test, followed by Dunn’s procedure, was used to compare the data between groups. Result PV demonstrated greater pH and fluoride release stability than the experimental materials. E5000B exhibited a slight reduction of fluoride release ( p < 0.01, R²=0.656) and an increase in pH with time ( p = 0.006, R²=0.233). The highest increase in mineral-to-collagen ratio at 14 days was detected with PV ( p < 0.05). E5000B also showed a significantly higher ratio than E5000 ( p = 0.014). SEM-EDX detected mineral precipitation on dentin treated with PV and E5000B but not in E5000 and DI. The cell viability of PV (56%) was significantly lower than that of E5000 (94%) and E5000B (89%) ( p < 0.05). Conclusion The use of 5000 ppm fluoride toothpaste enhanced the remineralization of irradiated demineralized dentin, highlighting a potentially valuable strategy for preventing radiation caries. Adding bioactive glass further promoted remineralization but may require formulation adjustments to maintain toothpaste stability for clinical use.

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Film-Forming Polymers for Tooth Erosion Prevention

Cited by 4 publications

References 96 publications

Film-Forming Polymers for Inhibition of Hydroxyapatite Dissolution: A Screening Study

Film-Forming Polymers for Inhibition of Hydroxyapatite Dissolution: A Screening Study

Effect of combining aminomethacrylate and fluoride against erosive and abrasive challenges on enamel and dentin

Effect of a 1.1% NaF toothpaste containing Sr/F-doped bioactive glass on irradiated demineralized dentin: an in vitro study

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