FilmArray GI-panel performance for the rapid and multiple detection of gastrointestinal microorganisms in foodborne illness outbreaks in Shenzhen during 2018–2019

Hu, Pengwei; Liu, Chuyun; Ruan, Jiawen; Meng, Yuan; Ju, Changyan; Ma, Yanping; Yuan, Yueming; Chen, Hui; Yu, Mei; Duan, Yueqiang

doi:10.1016/j.meegid.2020.104607

Cited by 8 publications

(6 citation statements)

References 22 publications

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“…The pathogenic factors of acute gastroenteritis include viruses, bacteria, parasites, toxins and metals. Acute gastroenteritis is most commonly seen in patients infected with at least one pathogen through food intake ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

Economic Burden and Influencing Factors of Acute Gastroenteritis in China: A Population-Based Face to Face Survey in 2018

Huo

Gao

Wang

et al. 2022

Front. Public Health

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BackgroundAcute gastroenteritis is an important and highly prevalent public health problem worldwide. The purpose of this study was to assess the economic burden of disease and its influencing factors in patients with acute gastroenteritis in Heilongjiang Province, China.MethodsA multi-stage stratified random sampling method was used in a face-to-face household survey in 2018. Demographic and socioeconomic characteristics, clinical symptoms, suspicious dietary history, and disease treatment information were collected from 19,647 respondents. One-way analysis of variance and multiple stepwise regression analysis were used to investigate the factors associated with the economic burden of acute gastroenteritis. Quantitative risk analysis and sensitivity analysis were performed to estimate the uncertainty and risk factors of the economic burden of acute gastroenteritis.ResultsThe total economic burden of patients with acute gastroenteritis was 63,969.22 CNY (Chinese Yuan), of which the direct economic burden accounted for 63.82%; the per capita economic burden was 131.35 CNY per month. Age, region, disease duration, and disease treatment were the main factors significantly associated with the economic burden of acute gastroenteritis (P < 0.05). The average economic burden of patients with acute gastroenteritis was approximately 571.84 CNY/person (95% CI: 227–1,459). Sensitivity analysis showed that the greatest impact was from the indirect economic burden.ConclusionsAcute gastroenteritis brings a substantial health burden to patients due to its high incidence. The economic burden of self-purchased drugs and the indirect economic burden of patients cannot be ignored. To better estimate the economic burden of acute gastroenteritis in China, further studies on the pathogen-specific economic burden of acute gastroenteritis are required.

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Section: Introductionmentioning

confidence: 99%

Economic Burden and Influencing Factors of Acute Gastroenteritis in China: A Population-Based Face to Face Survey in 2018

Huo

Gao

Wang

et al. 2022

Front. Public Health

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“…Samples collected ( n = 113) included rectal swabs or stool samples from case-patients ( n = 76) and food handlers ( n = 11), food samples ( n = 19), and kitchenware (cutting boards, serving plates, refrigerator, and mayonnaise mixing bowl; n = 7) from the nursery canteen. Stool samples from 10 cases with severe symptoms were processed using the FilmArray GI panel (BioFire Diagnostics, Salt Lake City) multiplex PCR as previously described ( Hu et al, 2020 ). All samples were enriched and screened for common foodborne pathogens including Salmonella , Shigella , Vibrio parahaemolyticus , Vibrio cholerae , Staphylococcus aureus , Escherichia coli O157:H7, enterotoxigenic Escherichia coli , enteropathogenic Escherichia coli , enteroinvasive Escherichia coli , enterohemorrhagic Escherichia coli , Bacillus cereus , group A Streptococcus , and Listeria monocytogenes , as previously described ( Hu et al, 2008 ).…”

Section: Methodsmentioning

confidence: 99%

Rapid Multilateral and Integrated Public Health Response to a Cross-City Outbreak of Salmonella Enteritidis Infections Combining Analytical, Molecular, and Genomic Epidemiological Analysis

et al. 2022

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On September 21, 2019, the Shenzhen and Dongguan Centers for Disease Control and Prevention received notification of a large cluster of suspected gastroenteritis involving primarily children who sought medical care at hospitals throughout two adjacent cities in China, Shenzhen, and Dongguan. A joint outbreak response was promptly initiated across jurisdictions in a concerted effort between clinical microbiologists, epidemiologists, and public health scientists. Concurrently, multiplex PCRs were used for rapid laboratory diagnosis of suspected cases; epidemiological investigations were conducted to identify the outbreak source, complemented by near real-time multicenter whole-genome analyses completed within 34 h. Epidemiological evidence indicated that all patients had consumed egg sandwiches served on September 20 as snacks to children and staff at a nursery in Dongguan, located near Shenzhen. Salmonella Enteritidis was isolated from case-patients, food handlers, kitchenware, and sandwiches with kitchen-made mayonnaise. Whole-genome single-nucleotide polymorphism (SNP)-based phylogenetic analysis demonstrated a well-supported cluster with pairwise distances of ≤1 SNP between genomes for outbreak-associated isolates, providing the definitive link between all samples. In comparison with historical isolates from the same geographical region, the minimum pairwise distance was >14 SNPs, suggesting a non-local outbreak source. Genomic source tracing revealed the possible transmission dynamics of a S. Enteritidis clone throughout a multi-provincial egg distribution network. The efficiency and scale with which multidisciplinary and integrated approaches were coordinated in this foodborne disease outbreak response was unprecedented in China, leading to the timely intervention of a large cross-jurisdiction Salmonella outbreak.

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“…Durante a investigação clínico-epidemiológica de um paciente com DTAs é importante valorizar dados sobre hábitos alimentares, consumo de alimentos suspeitos ou refeições incrimináveis, tempo de doença clínica, existência de outros familiares ou comensais com a mesma sintomatologia. A fim de facilitar o diagnóstico etiológico provável nas DTAs, é comum estudar agrupando-as a partir da observação de sinais e sintomas (síndromes clínicas) que surgem mais precocemente ou são predominantes (Hu et al, 2020).…”

Section: Alimento Causador Do Surto N %unclassified

Análise epidemiológica dos surtos de Doenças Transmitidas por Alimentos (DTAs) no estado do Piauí entre os anos de 2015 a 2019

Sousa

Costa²,

Rodrigues³

et al. 2021

RSD

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O presente trabalho teve como objetivo analisar o perfil epidemiológico dos surtos por doenças transmitidas por alimentos no estado do Piauí entre os anos de 2015 a 2019. Foram utilizadas informações do banco de dados do Sistema de Informação de Agravos de Notificação (SINAN), por meio do programa TABNET, recorrendo ao meio eletrônico. Por se tratar de um banco de dados de domínio público, disponibilizados pelo Sistema Único de Saúde (SUS), não houve necessidade de submeter o trabalho ao Comitê de Ética e Pesquisa (CEP). Trata-se de um estudo descritivo, ecológico, retrospectivo, de abordagem quantitativa de dados secundários. Os dados analisados referentes aos surtos de Doenças Transmitidas por Alimentos (DTAs) no estado do Piauí, notificados entre os anos de 2015 a 2019, evidenciaram um grande número de subnotificações, poucas identificações laboratoriais, apenas 12,5%, consequentemente tornando mínima a caracterização dos agentes etiológicos e impossibilitando a classificação das DTAs. Além disso na maioria dos casos 78,95 % o alimento causador do problema de saúde é ignorado, contribuindo para o desconhecimento da origem e impedindo ações de controle de produção e dificulta o esclarecimento da população quanto aos cuidados que devem tomar a fim de diminuir os riscos.

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FilmArray GI-panel performance for the rapid and multiple detection of gastrointestinal microorganisms in foodborne illness outbreaks in Shenzhen during 2018–2019

Cited by 8 publications

References 22 publications

Economic Burden and Influencing Factors of Acute Gastroenteritis in China: A Population-Based Face to Face Survey in 2018

Economic Burden and Influencing Factors of Acute Gastroenteritis in China: A Population-Based Face to Face Survey in 2018

Rapid Multilateral and Integrated Public Health Response to a Cross-City Outbreak of Salmonella Enteritidis Infections Combining Analytical, Molecular, and Genomic Epidemiological Analysis

Análise epidemiológica dos surtos de Doenças Transmitidas por Alimentos (DTAs) no estado do Piauí entre os anos de 2015 a 2019

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