Films based on soy protein-agar blends for wound dressing: Effect of different biopolymer proportions on the drug release rate and the physical and antibacterial properties of the films

Abstract

No single material can provide all requirements for wound dressings. Here, we evaluated the influence of different soy protein isolate and agar proportions (3:1, 1:1, and 1:3) in blend films on some of their physical-chemical and antibacterial properties to elucidate their potential as wound dressings. The films were synthesized by the gel casting method and ciprofloxacin hydrochloride was incorporated into the films. Films were characterized based on their surface morphology, water uptake ability, and weight loss profile. Also, the ciprofloxacin hydrochloride release kinetics was quantified spectrophotometrically. The antibacterial effect was evaluated against Staphylococcus aureus and Pseudomonas aeruginosa strains. The soy protein isolate-agar ratio affected the water uptake of the films and the release profile of ciprofloxacin hydrochloride but not the weight loss profile. The amount of drug released decreased near 80% because of the decrease in agar content in the films. The release kinetics of ciprofloxacin hydrochloride data best fitted to the Korsmeyer-Peppas model, suggesting that the mechanism of drug release was mainly of the diffusion type. All ciprofloxacin hydrochloride-releasing soy protein isolate-agar films strongly inhibited the cell viability of the bacterial strains studied. We concluded that water uptake and ciprofloxacin hydrochloride release can be controlled by changing the soy protein isolate-agar proportion. The proportions did not lead to changes in the antibacterial strength of the films.

pH‐activated polymeric profragrances for dual‐controllable perfume release

“…Inspired by fitting with kinetic models of drug release in solution, we employed three classic kinetic models to fit above release performance of all obtained polymer profragrances 38‐42 . As imitated, three classical dissolution‐diffusion mathematical kinetic models Zero Order kinetics (Q = kt + C), First Order kinetics (Q = C[1−e −kt ]), and Korsmeyer–Peppas kinetics (Q = kt n + C) were illustrated to describe kinetic release behaviors of polymer fragrance delivery system in solution (Figure 4B–D, Figure 4F–H, Figure 4J–L).…”

Marine Polysaccharides for Wound Dressings Application: An Overview

“…The drug was released abruptly within the first 2 h, followed by a slowrelease period of 2 weeks. Furthermore, the diffusive release period and amount of drug could be controlled by adjusting the agar content [191]. Agar gels also achieve high drug loading capacity while meeting proper mechanical strength and biocompatibility [192].…”

Applications of Biopolymers for Drugs and Probiotics Delivery

“…When used as an encapsulating agent, the larger the mass of agar in the beads, the denser the matrix formed and the lower the transfer of drug molecules through the beads. Similarly, the beads that contain a lower percentage of agar in the composition have a higher water content, which explains the rapid rate of drug release [ 131 ]. Therefore, agar can be used for the development of sustained-release dosage systems because it is a natural, inert, non-toxic, renewable, biocompatible, and inexpensive material.…”