Marine Polysaccharides for Wound Dressings Application: An Overview

Abstract

Wound dressings have become a crucial treatment for wound healing due to their convenience, low cost, and prolonged wound management. As cutting-edge biomaterials, marine polysaccharides are divided from most marine organisms. It possesses various bioactivities, which allowing them to be processed into various forms of wound dressings. Therefore, a comprehensive understanding of the application of marine polysaccharides in wound dressings is particularly important for the studies of wound therapy. In this review, we first introduce the wound healing process and describe the characteristics of modern commonly used dressings. Then, the properties of various marine polysaccharides and their application in wound dressing development are outlined. Finally, strategies for developing and enhancing marine polysaccharide wound dressings are described, and an outlook of these dressings is given. The diverse bioactivities of marine polysaccharides including antibacterial, anti-inflammatory, haemostatic properties, etc., providing excellent wound management and accelerate wound healing. Meanwhile, these biomaterials have higher biocompatibility and biodegradability compared to synthetic ones. On the other hand, marine polysaccharides can be combined with copolymers and active substances to prepare various forms of dressings. Among them, emerging types of dressings such as nanofibers, smart hydrogels and injectable hydrogels are at the research frontier of their development. Therefore, marine polysaccharides are essential materials in wound dressings fabrication and have a promising future.

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

“…Moreover, the antimicrobial activity might be altered due to the intrinsic characteristics of chitosan or the synergy of polymer and active ingredients [69]. A variety of these strategies have been studied; chitosan-coating of MPs and NPs, chitosan-functionalized systems, encapsulated chitosan, hybrid systems including chitosan, and surface modification of drug delivery systems [8,22,[70][71][72]. Moreover, the preparation method can tailor the properties of chitosan to improve the suitability of formulation for the specific routes of application [8,73].…”

“…Generally, chitosan is considered nontoxic as well as biocompatible and biodegradable and already frequently utilized in delivery systems and scaffolds intended for topical administration [71]. Several products comprising chitosan are already approved by the U.S. Food and Drug Administration for certain applications [42], such as wound dressings and sponges with hemostatic properties and could be found on the market [361].…”

Nutritional Therapy in Persons Suffering from Psoriasis

“…Recent reports indicate a beneficial effect of probiotic supplementation in patients with psoriasis [ 69 , 70 ] Polysaccharides, which are components of dietary fibre, show prebiotic effects, beneficially altering the intestinal microflora. Studies by Takahashi et al [ 60 ] and other reports [ 71 , 72 ] indicate that fucoidan, a sulfated polysaccharide found in the cell walls of brown seaweed, exhibits anticoagulant, anticancer, immunomodulatory, and apoptosis-inducing effects. Fucoidan has also been found to have a positive effect on the intestinal barrier and the composition of the bacterial flora, as well as improving the course of psoriasis [ 60 ].…”

Recent Advances in Functional Polymer Materials for Energy, Water, and Biomedical Applications: A Review

“…Actually, bioactive natural polymers, such as chitosan, alginate, carrageenan, and various polysaccharide extracts from plants were grafted onto various textile biomaterials, including implants and wound dressings. Successful chemical grafting without altering the different mechanical, swelling, and microbiological properties of the grafted biopolymers afforded excellent and promising functionalized textile biomaterials with enhanced physical, bacterial, and biological performance [195][196][197][198][199][200][201][202][203][204][205][206][207][208].…”