Filtration Surgery in the Treatment of Neovascular Glaucoma

Prognostic risk factors for failure of trabeculectomy with mitomycin C after vitrectomy

“…NVG has repeatedly been identified as a significant risk factor in the failure of filtering surgery, because continuous inflammation of the conjunctiva in eyes with NVG promotes an aggressive postoperative wound healing [7][8][9]. In agreement with those reports, we found by means of multivariable analysis (RR, 1.88; P = 0.049) that this type of glaucoma was an independent prognostic factor for failure of trabeculectomy in vitrectomized eyes.…”

Simultaneous increases in multiple proinflammatory cytokines in the aqueous humor in pseudophakic glaucomatous eyes

“…Numerous risk factors, including cataract surgery, are significantly associated with a poor surgical outcome of trabeculectomy, a representative surgical therapeutic modality against glaucoma. [2][3][4][5][6][7][8] We previously reported that even modern phacoemulsification could be a risk factor for the poor surgical outcome of mitomycin-C trabeculectomy. 6 One possible explanation for the poor outcome of trabeculectomy in cases with such risk factors might be prolonged inflammatory responses elicited by the surgical intervention.…”

Management of Neovascular Glaucoma

“…28 In a limited number of patients in whom it was not possible to perform PRP, GP alone has not proved to be beneficial in preventing synechial angle closure, and, at times, has caused increased inflammation and seemingly more rapid progression of angle NVA. The role of GP in the treatment of NVG is unclear.…”

“…Also, the presence of active neovascularization may lead to late bleb failure through conjunctival scarring at the filtration site. Using standard filtration techniques with preoperative PRP, surgical success (IOP less than 25 mm Hg on one medication or less) has been reported as 67% 28 and 77%.…”