1995
DOI: 10.1128/iai.63.12.4669-4674.1995
|View full text |Cite
|
Sign up to set email alerts
|

FimA, a major virulence factor associated with Streptococcus parasanguis endocarditis

Abstract: Adherence of microorganisms to damaged heart tissue is a crucial event in the pathogenesis of infective endocarditis. In the present study, we investigated the role of the FimA protein as a potential virulence factor associated with Streptococcus parasanguis endocarditis. FimA is a 36-kDa surface protein that is a recognized adhesin in the oral cavity where it mediates adherence to the salivary pellicle. An insertion mutant and a deletion mutant of S. parasanguis were employed in the rat model of endocarditis … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

1
61
0
2

Year Published

1998
1998
2023
2023

Publication Types

Select...
4
3
2

Relationship

0
9

Authors

Journals

citations
Cited by 155 publications
(65 citation statements)
references
References 27 publications
1
61
0
2
Order By: Relevance
“…Immunoelectron microscopy revealed that FimA was localized at the tips of the fimbriae . Moreover, FimA was demonstrated to be an important virulence determinant of S. parasanguinis-induced endocarditis, maybe playing a role in adherence to fibrin deposits associated with damaged cardiac valves (Burnette-Curley et al, 1995).…”
Section: Other Fimbrial Proteinsmentioning
confidence: 99%
“…Immunoelectron microscopy revealed that FimA was localized at the tips of the fimbriae . Moreover, FimA was demonstrated to be an important virulence determinant of S. parasanguinis-induced endocarditis, maybe playing a role in adherence to fibrin deposits associated with damaged cardiac valves (Burnette-Curley et al, 1995).…”
Section: Other Fimbrial Proteinsmentioning
confidence: 99%
“…Bacterial Nramp homologues, called MntH, are selective Mn transporters that play a role in the response to reactive oxygen species and may have a role in pathogenesis (Kehres et al, 2000;Makui et al, 2000). In addition, the ATP-binding cassette (ABC) family of Mn transporters (Claverys, 2001) was clearly shown to be important during infections caused by Enterococcus faecalis (Singh et al, 1998), Streptococcus pneumoniae and Streptococcus parasanguinis (Burnette-Curley et al, 1995;Berry and Paton, 1996) and Yersinia pestis (Bearden and Perry, 1999). Thus, Mn can be added to the in vivo growth requirements of many pathogens (Posey and Gherardini, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…In S. gordonii, which colonizes most oral cavity surfaces, the LraI polypeptide designated ScaA is a prominent cell-surface lipoprotein antigen (Kolenbrander et al, 1994) and has been implicated in interbacterial adhesion or coaggregation (Andersen et al, 1993). LraI polypeptides have also been implicated in adhesion of oral streptococci to salivary glycoproteins and fibrin (Ganeshkumar et al, 1991;Oligino and Fives-Taylor, 1993;Burnette-Curley et al, 1995), in binding of group B streptococci to laminin (Spellerberg et al, 1999), and in adhesion of pneumococci to epithelial cells (Berry and Paton, 1996). The homologous proteins FimA (S. parasanguinis), PsaA (S. pneumoniae), EfaA (Enterococcus faecalis) and SloC (S. mutans) have all been shown to be essential for virulence of bacteria in experimental animal models (Burnette-Curley et al, 1995;Berry and Paton, 1996;Singh et al, 1998;Kitten et al, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…LraI polypeptides have also been implicated in adhesion of oral streptococci to salivary glycoproteins and fibrin (Ganeshkumar et al, 1991;Oligino and Fives-Taylor, 1993;Burnette-Curley et al, 1995), in binding of group B streptococci to laminin (Spellerberg et al, 1999), and in adhesion of pneumococci to epithelial cells (Berry and Paton, 1996). The homologous proteins FimA (S. parasanguinis), PsaA (S. pneumoniae), EfaA (Enterococcus faecalis) and SloC (S. mutans) have all been shown to be essential for virulence of bacteria in experimental animal models (Burnette-Curley et al, 1995;Berry and Paton, 1996;Singh et al, 1998;Kitten et al, 2000). In S. gordonii, S. parasanguinis and S. pneumoniae the LraI polypeptide is encoded by the third gene of an operon that encodes the components of an ATP-binding cassette (ABC)-type transporter.…”
Section: Introductionmentioning
confidence: 99%