FIN56-Loaded Graphdiyne Nanoplatforms for Photothermal-Ferroptosis Synergistic Therapy Against Glioblastoma

Zhao, Lingxiao; He, Da-Long; Zhang, Qi; Gong, Zhiqiang; Ge, Ri-Le; Meng, J.; Ren, Hang; Fan, Yingcai; Wang, Zhan-You

doi:10.2139/ssrn.4300198

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…43,269,382 Classical III FINs deplete the GPX4 protein and CoQ 10 to induce ferroptosis, such as FIN56. 45,[466][467][468][469] Class IV FINs induce ferroptosis by augmenting the LIP, such as FINO 2 . 136 These tool compounds have made significant contributions to the understanding of the mechanism of ferroptosis due to their specificity towards ferroptosis.…”

Section: Systemic Drugsmentioning

confidence: 99%

Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies

Zhou,

Meng,

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate tumor suppressor mechanism and participates in the biological processes of tumors. Intriguingly, mesenchymal and dedifferentiated cancer cells, which are usually resistant to apoptosis and traditional therapies, are exquisitely vulnerable to ferroptosis, further underscoring its potential as a treatment approach for cancers, especially for refractory cancers. However, the impact of ferroptosis on cancer extends beyond its direct cytotoxic effect on tumor cells. Ferroptosis induction not only inhibits cancer but also promotes cancer development due to its potential negative impact on anticancer immunity. Thus, a comprehensive understanding of the role of ferroptosis in cancer is crucial for the successful translation of ferroptosis therapy from the laboratory to clinical applications. In this review, we provide an overview of the recent advancements in understanding ferroptosis in cancer, covering molecular mechanisms, biological functions, regulatory pathways, and interactions with the tumor microenvironment. We also summarize the potential applications of ferroptosis induction in immunotherapy, radiotherapy, and systemic therapy, as well as ferroptosis inhibition for cancer treatment in various conditions. We finally discuss ferroptosis markers, the current challenges and future directions of ferroptosis in the treatment of cancer.

show abstract

Section: Systemic Drugsmentioning

confidence: 99%

Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies

Zhou,

Meng,

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

show abstract

“…84,85 Moreover, the PCE of carbon-based nanomaterials is higher than that of gold nanoparticles. 86 To date, different kinds of carbon-based nanostructures have been developed as PTAs including carbon nanodots (CNDs), 87 also known as carbon quantum dots (CQDS), 88 carbon nanotubes (CNTs) 89 (including single-walled carbon nanotubes (SCNTs) and multi-walled carbon nanotubes (MCNTs)), carbon nano- Review Biomaterials Science diamonds (CNDs), 90 mesoporous carbon nanoparticles (MCNs), hollow carbon nanospheres (HCNs), 91 graphylene graphdiyne (GDY) 92 and graphene-based nanomaterials (GBNs) 93 (can be further divided into graphene with different layers, graphene oxide (GO) 94 and reduced graphene oxide (rGO) 95 ). In the following sections of this review, we discuss some of the carbon-based nanomaterials mentioned above.…”

Section: Introduction and Mechanism Of Photothermal Therapy (Ptt)mentioning

confidence: 99%

Photothermal therapy: a novel potential treatment for prostate cancer

Dong,

Xue,

Verma

et al. 2024

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

“… 11 Inorganic nanoparticles are mainly made of inorganic materials, such as graphene, carbon nanotubes, gold nanoparticles, silica nanoparticles, and iron oxide nanoparticles. 12–18 Many natural and synthetic polymers with good biocompatibility and low toxicity are used to prepare nanocarriers, such as polymer nanoparticles, polymer micelles, and dendrimers, to accurately deliver and improve the efficacy of drugs. 19–21 …”

Section: Introductionmentioning

confidence: 99%