Short-range correlations (SRC) in asymmetric nuclei with an unusual neutronto-proton ratio can be studied with quasi-free two-nucleon knockout processes following the collision between accelerated ions and a proton target. We derive an approximate factorized cross section for those SRC-driven p(A, p N 1 N 2 ) reactions. Our reaction model hinges on the factorization properties of SRC-driven A(e, e N 1 N 2 ) reactions for which strong indications are found in theory-experiment comparisons. In order to put our model to the test we compare its predictions with results of 12 C(p, p pn) measurements conducted at Brookhaven National Laboratory (BNL) and find a fair agreement. The model can also reproduce characteristic features of SRC-driven two-nucleon knockout reactions, like back-to-back emission of the correlated nucleons. We study the asymmetry dependence of nuclear SRC by providing predictions for the ratio of proton-proton to proton-neutron knockout cross sections for the carbon isotopes 9−15 C thereby covering neutron excess values (N − Z)/Z between -0.5 and +0.5.