Finding New Overlapping Genes and Their Theory (FOG Theory)

Scherer, Stephen W.; Neuhaus, Klaus; Bossert, Martin; Mir, Katharina; Keim, Daniel A.; Simon, Svenja

doi:10.1007/978-3-319-54729-9_5

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2023

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“…However, very short overlaps, which are used as translational coupling of open reading frames (ORFs) in a polycistronic operon, are not considered as overlapping genes here. The protein parts encoded in the short overlapping areas are minor only and normally do neither form a domain, nor have a function on protein level ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

“…In any case, the examples of established bacterial overlapping genes known to date suggest that such genes tend to be taxonomically restricted ( 21 , 22 , 24 ). Studies have shown that overlapping genes typically code for specialized rather than basic cellular functions ( 2 ). In addition, overlapping genes tend to have a larger degree of structural disorder compared to proteins encoded by non-overlapping genes ( 28 ) and it is assumed that overlapping genes emerge de novo through a process termed overprinting ( 29 , 30 ).…”

Section: Introductionmentioning

confidence: 99%

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