“…Moreover, the Rapidity and non-invasive properties of Raman spectroscopy also enable its potential as an intraoperative inspection method to improve the EOR of glioma surgery, so as to improve surgical outcomes and promote patient prognosis ( 13 – 15 ). Numerous studies have reported the applicability of Raman spectroscopy in the diagnosis of several tumors, which include colorectal cancer ( 16 ), breast cancer ( 17 ), nasopharyngeal carcinoma ( 18 ), skin cancer ( 19 , 20 ), gastric cancer ( 21 ), and prostate cancer ( 22 ), etc. These studies show the prospect of Raman spectroscopy as a novel surgical adjunct to assist in the diagnosis of tumors, and the prominence of Raman spectroscopy in the diagnosis of these tumors and its specific properties - non-invasive, rapid, and accurate - makes it potentially capable of supporting neurosurgeons in the rapid identification of glioma boundaries during surgery ( 8 , 23 , 24 ).…”