In this paper, we present a model that relates epistemic practices and socio-scientific issues (SSI) in science education. In order to develop it, we establish interweavings between norms, practices, epistemic objectives, epistemic cognition, informal reasoning, epistemic practices and justified positioning. We suggest that epistemic cognition is the link between reasoning and epistemic practices. We present three epistemic goals that should guide work with epistemic practices when solving a SSI: recognising and using multiple lines of reasoning when solving the SSI, construction and evaluation of holistic arguments aiming to understand the multiple dimensions of the SSI and the development of sceptical investigations to resolve the SSI. The stated objectives contribute to the critical assessment and resolution of the SSI. We believe that for the construction of social norms in teaching environments with SSI, it should be considered that these questions do not require a “single” answer and, therefore, a space for reflection, awareness and justification of the different perspectives on the question must be allowed. The relationships established in this article contribute to research that aims to develop and analyse epistemic practices “in situ” in teaching contexts with SSI. In addition, they have the potential to provide support to teachers who wish to favour the occurrence of epistemic practices in a SSI approach.