Findings of the International Nosocomial Infection Control Consortium (INICC), Part III Effectiveness of a Multidimensional Infection Control Approach to Reduce Central Line—Associated Bloodstream Infections in the Neonatal Intensive Care Units of 4 Developing Countries

Abstract

Implementation of a multidimensional infection control approach was associated with a significant reduction in CLABSI rates in NICUs.

Clinical impact and cost-effectiveness of split-septum and single-use prefilled flushing device vs 3-way stopcock on central line–associated bloodstream infection rates in India: a randomized clinical trial conducted by the International Nosocomial Infection Control Consortium (INICC)

“…5 Within the scope of other studies addressing the burden of CLABSIs in India, the CLABSI rate in our 3WSC group was similar to the rate of 7.92 CLABSIs per 1000 CL-days found in a 2007 study. 3 In previous studies performed by INICC member hospitals, it was shown that the implementation of a 6-component multidimensional approach for CLABSI resulted in significant reductions in CLABSI rates in Argentina (45.9 vs 11.1 CLABSIs per 1000 CL-days), 13 in Mexico (46.3 vs 19.5 CLABSIs per 1000 CL-days), 12 in Turkey (22.7 vs 12.0 CLABSIs per 1000 CL-days), 9 in India (6.4 vs 3.9 CLABSIs per 1000 CL-days), 8 11 However, in none of the previous studies conducted by INICC the CLABSI rate was lower than 5.2 CLABSIs per 1000 CL-days, as was achieved in the SS þ SUF group. [8][9][10][11][12][13][14] This finding is consistent with the fact that according to the INICC, between 88% and 94% of hospitals in the developing world use 3WSC devices instead of SS þ SUF devices.…”

“…6,7 However, to date only 2 studies addressing this issue have been published, which showed higher CLABSI rates in pediatric ICUs in lower-middle-income countries compared with upper-middle-income countries, 6 and significantly higher CLABSI rates in neonatal ICU patients from low-income countries than in lower-middle or upper-middle-income countries. 7 In the developing countries, including India, 8 it has been demonstrated that CLABSI rates can be reduced by more than 50% [8][9][10][11][12][13][14] by adopting a multidimensional approach with the simultaneous implementation of 6 elements: (1) a bundle of interventions, (2) education, (3) outcome surveillance, (4) process surveillance, (5) feedback on CLABSI rates and consequences, and (6) performance feedback.…”

Central-line-associated bloodstream infections in a resource-limited South African neonatal intensive care unit

“…[5,6] Central-line care bundle elements include: hand hygiene, optimal catheter-site selection, maximal barrier precautions at insertion, chlorhexidine skin antisepsis, daily review of line necessity, sterile line access, use of closed needleless intravascular catheter systems and ensuring the line dressing stays clean and intact. [5,6] Reductions in NICU CLABSI rates have been achieved in developing countries, [7] but data from African NICUs are extremely limited. [2] Our study reports the first CLABSI surveillance programme data from a public sector NICU in South Africa (SA) and aims to identify risk factors for CLABSI in this setting.…”

Some aspects of nosocomial infections dissemination in intensive care units of different profile

“…Средняя продолжительность госпитализа-ции больше при микробиологически подтвержденном ин-фицировании крови (ИК) (15,5 дня и 4-67 дней) и клини-ческом сепсисе (14 и 3-48 дней), чем при отсутствии этих осложнений (4 дня и 2-134 дня). Госпитальная леталь-ность при отсутствии ИК при микробиологически под-твержденном ИК и клиническом сепсисе составила 22,7, 32,1 и 39,7% соответственно [18]. На территории России, по данным исследования CASCAT, этот показатель со-ставляет 5 случаев на 1000 дней катетеризации.…”