Fine anatomy of neurosecretory cells in the human gingiva

Luzardo-Baptista, Mario J.; García‐Tamayo, Jorge

doi:10.1016/0030-4220(74)90346-6

Cited by 6 publications

(4 citation statements)

References 26 publications

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“…First, individual Merkel cells are present in significant numbers in all regions of the gingival mucosa. This finding differs from earlier reports in humans (Nikai et al, 1971;Luzardo-Baptista, 1974) and rats (Nikai et al, 1971) in which Merkel cells were stated to be relatively scarce in gingival mucosa.…”

Section: Discussioncontrasting

confidence: 99%

“…Merkel cells have been described by a number of investigators in a variety of anatomical setings including opossum snout skin (Munger, 19651, rat vibrissae (Patrizi and Munger, 1966), human Haarscheibe (Smith, 1967, 19701, touch corpuscles in cat hairy skin (Iggo and Muir, 19691, human oral mucosa (Hashimoto, 19721, and monkey hard palate (Munger, 1975; Garant, 1980). Only a few investigators (Nikai et al, 1971;Hashimoto, 1972; Luzardo-Baptista, 1974) have described the Merkel cell in gingival mucosa, and it has been concluded by most (Nikai et al, 1971; Luzardo-Baptista, 1974) that Merkel cells in this location are rare.…”

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confidence: 99%

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The morphology and distribution of Merkel cells in primate gingival mucosa

Turner

1983

Anat. Rec.

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The morphology and distribution of Merkel cells in primate gingival mucosa have been studied by correlated light and electron microscopic techniques. The gingival mucosa is composed of a stratified squamous epithelium with a dense underlying connective tissue stroma. The epithelium inter-digitates with the underlying connective tissue forming long interconnected rete ridges. Merkel cells and their associated axons are abundant in gingival mucosa where they are located, either individually or in clusters, at the base of epithelial rete ridges. These cells have an identical morphology to Merkel cells described by others in the hard palate, hairy skin, glabrous skin and eyelid. While individual Merkel cells are found throughout the gingival mucosa, Merkel cell clusters are most numerous in the mandibular lingual gingival mucosa. When correlating this finding with data from other investigators, it appears that Merkel cell clusters are located preferentially in the masticatory mucosa in intimate contact with the tongue and thus may function as an important source of somatosensory feedback providing valuable information regarding the position of the tongue in the oral cavity.

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Section: Discussioncontrasting

confidence: 99%

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confidence: 99%

The morphology and distribution of Merkel cells in primate gingival mucosa

Turner

1983

Anat. Rec.

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“…Merkel cells contain numerous neurosecretory granules that may liberate transmitter substance across the synapse-like cleft between cells and adjacent nervc fibers [73][74][75]. Functionally, these cells are supposed to have some neurosecretory activity and are now considered as a part of the APUD system [76,77], althouglno secretory polypeptide hormone has been identified in it until now.…”

Section: Discussionmentioning

confidence: 99%

Pigmented squamous cell carcinoma of the oral mucosa - with special reference to the role of non-keratinocytes in tumors and tumorous conditions.

Ide

Kusuhara

Ohnuma

et al. 1981

The Journal of Nihon University School of Dentistry

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“…22] and rats [22] and is identical to the ultrastructure of Merkel nerve endings in the skin (7|. Luzardo-Baptista and Garcia-Tamayo [18] and Wilgram [27] suggest that Merkel cells in the mucosa func tion through neurosecretion. Hashimoto [ 10] and Nikai et al [22] point out the similarity between Merkel cells with their osmiophilic granules and the endocrine cells of the adrenal medulla.…”

Section: Discussionmentioning

confidence: 70%

The Sensory Innervation of the Gingiva and Mucosa in <i>Monodelphis domestica</i>: An Ultrastructural Study

Schulze¹,

Spaethe²,

Halata³

1993

Cells Tissues Organs

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The location and structure of sensory nerve endings was examined in the mucosa and in the gingiva propria adjacent to the third premolar of Monodelphis domestica by light and electron microscopy. The mucous membrane of the gingiva propria is covered with a stratified keratinized squamous epithelium. The mucous membrane of the adjacent inner aspect of the lip and of the vestibulum oris were covered with a nonkeratinized squamous epithelium. Free nerve endings, Merkel nerve endings and lamellated corpuscles were found in all the examined areas. Free nerve endings were located in the connective tissue papillae between the epithelial cones, in the basal layer of the epithelium and directly under the epithelium of the cones. They were innervated by myelinated A-delta- and nonmyelinated C-fibers. The basal layer of the first three to four epithelial cones of the gingiva propria contained single or groups of Merkel nerve endings. The epithelial cones of the oral mucous membrane contained five times more Merkel nerve endings than those of the vestibular mucous membrane. Lamellated corpuscles were mainly found in the plica sublingualis. In the connective tissue below the epithelial cones of the mucous membranes they usually occur with a perineural capsule, in the connective tissue papillae between the cones they occur without a perineural capsule. In the latter position they resemble the Meissner corpuscles of glabrous skin. The density of receptors in the oral mucous membrane of the lower jaw of M. domestica implies that this richly innervated mechanoreceptive area acts as an antagonist of the tongue and provides important information during mastication.

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Fine anatomy of neurosecretory cells in the human gingiva

Cited by 6 publications

References 26 publications

The morphology and distribution of Merkel cells in primate gingival mucosa

The morphology and distribution of Merkel cells in primate gingival mucosa

Pigmented squamous cell carcinoma of the oral mucosa - with special reference to the role of non-keratinocytes in tumors and tumorous conditions.

The Sensory Innervation of the Gingiva and Mucosa in <i>Monodelphis domestica</i>: An Ultrastructural Study

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