Fine and ultrafine atmospheric particulate matter at a multi-influenced urban site: Physicochemical characterization, mutagenicity and cytotoxicity

Landkocz, Yann; Ledoux, Frédéric; André, Véronique; Cazier, Fabrice; Genevray, Paul; Dewaele, Dorothée; Martin, Perrine; Lepers, Capucine; Verdin, Anthony; Courcot, Lucie; Boushina, Saâd; Sichel, François; Gualtieri, Maurizio; Shirali, Pirouz; Courcot, Dominique; Billet, Sylvain

doi:10.1016/j.envpol.2016.11.054

Cited by 73 publications

(47 citation statements)

References 81 publications

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“…In the upper part of the flow chart, the BChemical and particle characterization^is displayed. About 70% of the publications characterize the chemical composition of the particle extracts [3,7,10,12,[17][18][19]. Out of these 55 publications in 30 articles, also particle characteristics were considered, with the Baverage PM concentration^mentioned most often [10, 19, 27, 29, 31, 34-36, 39, 40, 43, 46, 48, 50-53, 57-59, 63, 66, 67], the shape of the particles was analyzed in 12 publications [3,12,18,28,34,36,38,43,44,53,57,71], and the surface chemistry was considered only in 4 publications [7,18,19,70].…”

Section: Overview On Studiesmentioning

confidence: 99%

“…About 70% of the publications characterize the chemical composition of the particle extracts [3,7,10,12,[17][18][19]. Out of these 55 publications in 30 articles, also particle characteristics were considered, with the Baverage PM concentration^mentioned most often [10, 19, 27, 29, 31, 34-36, 39, 40, 43, 46, 48, 50-53, 57-59, 63, 66, 67], the shape of the particles was analyzed in 12 publications [3,12,18,28,34,36,38,43,44,53,57,71], and the surface chemistry was considered only in 4 publications [7,18,19,70]. Accordingly, 24 publications did not characterize chemicals attached to the particles [9,11,, and only 7 out of these 24 publications considered other particle characteristics [72,76,78,80,82,87,89], with Baverage PM concentration^being mentioned most often.…”

Section: Overview On Studiesmentioning

confidence: 99%

“…Often, only extracts of filter-sampled material are prepared and either the organic or the aqueous phase was subjected to testing for biological effects (e.g., [9][10][11]). By this procedure, the particles as well as other compounds are omitted from testing leading to a potential underestimation of the biological effects of combustionderived particles [7,12].…”

Section: Introductionmentioning

confidence: 99%

“…For combustion-derived particles, it has likewise been observed that sample collection, extraction from the filters, and resuspension in media may alter their toxicological properties [17]. The importance of considering combustion-derived particles in their entity for the evaluation of toxicity, in order to be able to also elucidate mixture effects, is emphasized in the literature [12,18,19], however difficult to test.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

From the air to the water phase: implication for toxicity testing of combustion-derived particles

Schmidt

Altenburger

Kühnel

2017

Biomass Conv. Bioref.

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The biological effects of airborne particulate matter (PM) in humans stimulated many research activities in recent years. One type of particles contributing to PM are those derived from combustion processes. By using in vitro test systems for assessing the toxic effects of those particles, the transfer into liquid media is necessary. Thus the question arises, how the transfer of airborne particles into liquid suspensions should be realized and how the exposure of test organisms/cells to the particles can be done and monitored with regard to concentration and stability. Further, the characterization of the airborne particles regarding their composition seems to be of importance in order to understand the induced biological effects. Hence, this review gathers and evaluates results from in vitro and ecotoxicity studies, where the introduction of airborne particles into liquids is required. The aim was to learn on the current practice and recommend on the design of toxicity studies in the future. In total, about 80 papers were retrieved by literature search that deal with the assessment of biological effects of combustion-derived particles or their constituents. The papers were evaluated in detail with regard to the methodology applied. From this evaluation and based on expert knowledge regarding nanoparticle testing, recommendations for the assessment of PM applying toxicological assays were developed. To provide guidance, essential criteria are developed that should help in preparation, testing, and during the evaluation phase of toxicological assays. We further advise whole particle testing, complemented by testing of particle extracts and washed particles.

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Section: Overview On Studiesmentioning

confidence: 99%

Section: Overview On Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

From the air to the water phase: implication for toxicity testing of combustion-derived particles

Schmidt

Altenburger

Kühnel

2017

Biomass Conv. Bioref.

View full text Add to dashboard Cite

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“…Several epidemiological studies have demonstrated that exposure to carbonaceous particulate matter (CPM) can lead to the development of pulmonary malfunctions, respiratory symptoms, cardiovascular diseases and increased hospital admission (Dockery et al, 1993;Schwartz et al, 1994;Pope et al, 2002, Czövek et al, 2012Longhin et al, 2016;Landkocz et al, 2017). Diesel engine exhaust has been classified as carcinogenic to humans (Group 1) by the World Health Organization (WHO) International Agency for Research on Cancer (IARC) (IARC, 2012).…”

Section: Introductionmentioning

confidence: 99%

Optical Properties, Chemical Composition and the Toxicological Potential of Urban Particulate Matter

Pintér

Utry

Ajtai

et al. 2017

Aerosol Air Qual. Res.

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This paper discusses the diurnal variation and the interdependences between the physical, chemical and toxicological characteristics of atmospheric carbonaceous particulate matter (CPM) and co-emitted gaseous components. Measurements were carried out at two different urban sites during a 2-month period. On-line measured parameters were optical absorption coefficients (OAC), total number concentration (TNC), mass concentration of CPM and the concentration of gaseous species (CO, NO x and BTEX). Off-line analyses were carried out on filters collected with 6-hour time resolution. The concentrations of elemental carbon (EC), organic carbon (OC), total carbon (TC), levoglucosan (LG) and polycyclic aromatic hydrocarbons (PAH) were determined. The ecotoxicity of CPM was assessed by the Vibrio Fischeri marine bioluminescence inhibition bioassay (ISO 21338:2010). We found (r > 0.498) positive and wavelength dependent correlation between the CPM related parameters based on optical response (OAC, AAE) and thermal stability (TC, EC, OC, OC/TC). We also revealed weak (r = 0.309) or moderate (r = 0.448) correlation between the AAE and the ecotoxicity data indicating that carbonaceous fraction of the ambient particulate matter has ecotoxicological impact. Based on the determined correlations, we propose the applicability of the AAE determined by multi wavelength photoacoustic measurements as a possible candidate for first-screening the toxicological impact of optically active carbonaceous ambient particulate matter. The strengths and the limitations of this methodology are both discussed here.

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Comparative mutagenic activity of atmospheric particulate matter from limeira, stockholm, and kyoto

Maselli

Giron

Lim

et al. 2019

Environ and Mol Mutagen

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Atmospheric particulate matter (PM) organic fractions from urban centers are frequently mutagenic for the Salmonella/microsome assay. This mutagenicity is related to both primary and secondary pollutants, and meteorological conditions have great influence on the secondary pollutant's formation. Our objective was to compare the mutagenicity of atmospheric total suspended particulates (TSP) from three cities with marked different meteorological conditions and TSP concentrations: Limeira (Brazil) with 99.0 μg/m3, Stockholm (Sweden) with 6.2 μg/m3, and Kyoto (Japan) with 28.0 μg/m3. For comparison, we used the same batch of filters, sample extraction method, and Salmonella/microsome testing protocol with 11 strains of Salmonella with and without metabolic activation. Samples were collected during winter and pooled into one single extract representing each city. All samples were mutagenic for all tested strains, except for TA102. Based on the strain's selectivity, nitroarenes, polycyclic aromatic hydrocarbons, and aromatic amines play a predominant role in the mutagenicity of these samples. The mutagenic potencies expressed by mass of extracted organic material (EOM; revertants/μg EOM) were similar (~twofold difference) among the cities, despite differences in meteorological conditions and pollution sources. In contrast, the mutagenic potencies expressed by air volume (rev/m3) varied ~20‐fold, with Limeira > Kyoto ≈ Stockholm. These results are the first systematic assessment of air mutagenicity from cities on three continents using the same protocols. The results confirm that the mutagenic potency expressed by EOM mass is similar regardless of continent of origin, whereas the mutagenic potency expressed by air volume can vary by orders of magnitude. Environ. Mol. Mutagen. 2019. © 2019 Wiley Periodicals, Inc.

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Fine and ultrafine atmospheric particulate matter at a multi-influenced urban site: Physicochemical characterization, mutagenicity and cytotoxicity

Cited by 73 publications

References 81 publications

From the air to the water phase: implication for toxicity testing of combustion-derived particles

From the air to the water phase: implication for toxicity testing of combustion-derived particles

Optical Properties, Chemical Composition and the Toxicological Potential of Urban Particulate Matter

Comparative mutagenic activity of atmospheric particulate matter from limeira, stockholm, and kyoto

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