Fine grade engineered microcrystalline cellulose excipients for direct compaction: Assessing suitability of different dry coating processes

Chen, Liang; He, Zizhou; Kunnath, Kuriakose; Zheng, Kai; Kim, Sangah; Davé, Rajesh N.

doi:10.1016/j.ejps.2020.105408

Cited by 14 publications

(6 citation statements)

References 34 publications

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“…Host particles were first weighed and then the amount of A200P needed to reflect the mass/mass ratio was added. For the test, 1.0% guest/host mass ratio was used with both host particles, which is a standard value used in literature [4,13,14,18,20,21]. Additionally, a 1.5% guest/host mass ratio and a 0.5% guest/host ratio were used for both FFL and MCC, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…The literature shows that the conical mill leads to dry coating of pharmaceutical powders as a continuous mode equipment [3,4,13,14,[18][19][20][21][22][23][24][25]. In some of those studies, the conical mill is compared to other types of equipment capable of dry coating [4,13,14]. The issue with these comparisons is that the processing time for some equipment is not equivalent.…”

Section: Batch Mode Experimentationsmentioning

confidence: 99%

“…The high intensity vibrational mixer sometimes, also referred to as the LabRam, uses acoustic Processes 2022, 10, 540 2 of 15 resonance to vibrate the chamber. The intense mixing generated in the equipment causes dry coating of the host particles [5,[14][15][16]. The fluid energy mill (FEM), uses a high-pressure gas to generate a vortex in its chamber.…”

Section: Introductionmentioning

confidence: 99%

“…The fluid energy mill (FEM), uses a high-pressure gas to generate a vortex in its chamber. Contacts between the particles and walls of the chamber at high velocity both grinds and dry coats the host particles [4,14,17]. Good results were obtained with these three types of equipment.…”

Section: Introductionmentioning

confidence: 99%

“…The MAIC and FEM are compatible with continuous mode manufacturing, but they each present some limitations. Another type of mill, the conical mill has also attracted the interest of some research groups for dry coating over the last ten years [3,4,13,14,[18][19][20][21][22][23][24]. Already used in the pharmaceutical industry for particle size reduction, this equipment has a conical chamber with a screen wall and an impeller at its center.…”

Section: Introductionmentioning

confidence: 99%

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A Continuous Conical-Mill Operation for Dry Coating of Pharmaceutical Powders: The Role of Processing Time

et al. 2022

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Over the last decade, the conical mill has emerged as a potential piece of equipment to use for continuous dry coating pharmaceutical powders. In this work, silicon dioxide was used as a guest particle on two excipients, fast flow lactose (FFL) and grade PH200 microcrystalline cellulose (MCC), for dry coating by a conical mill with a modified screen that permitted batch and continuous mode operation. Samples were pre-processed in a V-blender. SEM images, particle size distribution, and EDS mapping were used to characterise the treated powders. Pre-processed samples showed some discrete coating of the host particle. After batch processing, the samples were covered with a complete coating. When processed at high impeller speed, coating of FFL was a mix of A200P and FFL fines generated by attrition. Continuous mode processed samples, which had a lower processing time, were coated discretely and showed a better coating than the pre-processed samples. Increasing guest/host mass ratio with FFL host particle had a positive impact on the quality of the coating. These results help to build the case that the processing time of the conical mill is a key parameter to the success of the conical mill as dry coating equipment in the pharmaceutical industry.

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