Fine-needle aspiration biopsies of thyroid nodules

Abstract

Summary Objective: The purpose of the study was the characterization of adverse events (AEs) after fine-needle aspiration biopsies (FNABs) of thyroid nodules, as well as possible predisposing factors. Methods: A total of 205 patients, each of whom had undergone an FNAB of a thyroid nodule, were included in the study (15 of whom were taking anticoagulant medication). The thyroid nodules were classified according to the ultrasound criteria of the American Thyroid Association (ATA). The FNABs were carried out by four trained nuclear medicine specialists from two institutions. To detect AEs, all patients were asked to fill out a standardized self-assessment questionnaire. Results: Out of 205 patients, 189 (92 %) reported no AEs. Fourteen patients (6.8 %) had mild or moderate AEs, such as short-term pain at the puncture site. In two patients (1 %), the AEs were classified as significant, and required medical followup, which revealed an intrathyroid hematoma in one patient and dysphonia in the other. All AEs were reversible. None of the patients taking anticoagulants experienced any AEs. The parameters of age, sex, nodule volume, ATA nodule type, needle size, and physician performing the biopsy were not predisposing factors for side effects (p = 0.54, p = 0.73, p = 0.75, p = 0.94, p = 0.35, and p = 0.24, respectively). Conclusions: The vast majority of patients tolerated the FNAB very well. AEs were seldom observed. A small number of patients experienced AEs that required no intervention or could be self-managed by the patient. Considering the almost negligible risk of the procedure, FNAB should be increasingly used for the classification of thyroid nodules.

Semiquantitative Parameters in PSMA-Targeted PET Imaging with [18F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake

“…For the entire tumor burden, the following parameters were assessed: SUL mean , the maximum standardized uptake value corrected to lean body mass (SUL max ), SUV mean , tumor volume (TV) and the fractional tumor activity (FTA) in the VOI. The latter parameter is well-established in the literature and has also been referred to as tumor lesion (TL)-PSMA [21][22]. FTA was calculated as follows: [TV x SUV mean ].…”

Utilidad diagnóstica de citopatología para diagnóstico de nódulos tiroideos malignos en un hospital peruano

“…Así, tenemos que la punción aspiración con aguja fina (PAAF) es la prueba diagnóstica de primera línea para el estudio de los nódulos tiroideos, puesto que es mínimamente invasiva, rápida, la más precisa y costo-efectiva, recomendada a nivel internacional [4,5] . Esta técnica diagnóstica reduce las cirugías innecesarias [5] y no presenta eventos adversos importantes [6] . El resultado de la PAAF se informa utilizando el sistema de Bethesda para informar la citopatología de tiroides, que brinda seis categorías desde el I (no diagnóstica) hasta el VI (maligna).…”

“…El resultado de la PAAF se informa utilizando el sistema de Bethesda para informar la citopatología de tiroides, que brinda seis categorías desde el I (no diagnóstica) hasta el VI (maligna). Sin embargo, la sensibilidad y especificidad de esta prueba no es igual en todos los centros donde se la ejecuta, varía de 57,89 a 98,3% y de 30,9 a 98,05%, respectivamente [2,6,7] . La experiencia en el procedimiento y en la interpretación citopatológica son factores que influyen en el rendimiento de la PAAF.…”

Analysis of the Interreader Agreement on Structured Reports of Pelvic Multiparametric Magnetic Resonance Imaging Using the METastasis Reporting and Data System for Prostate Cancer (METRADS- P) Guidelines

“…Given that PCa initially and predominantly metastasizes to pelvic lymph nodes and bone, and that extrapelvic metastases in the absence of pelvic involvement are rare, 7,8 a routine pelvic examination is adequate for the metastasis detection and response evaluation for PCa patients. 9,10 In this setting, the researchers tailored a structured report for follow-up pelvic multiparametric MRI (mp-MRI), taking the MET-RADS-P template for reference. This was used with a cohort of patients with APC at the study site, mimicking a typical clinical workflow.…”