Fine-needle aspiration biopsy diagnosis of small round cell tumors of childhood: A comprehensive approach

Akhtar, Mohammed; Iqbal, M A; Mourad, Walid A.; Ali, Mohammed Ashraf

doi:10.1002/(sici)1097-0339(199908)21:2<81::aid-dc2>3.0.co;2-a

Cited by 59 publications

(57 citation statements)

References 58 publications

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“…Distinctive cytologic features include background neuropil and Homer Wright pseudorosettes. 19,21,[23][24][25] Wilms tumor, or nephroblastoma, also occurs in a very young age group. Aspirate material demonstrates various combinations of blastema, epithelium, and stroma, but the blastema, which represents the small blue cell component, is present consistently.…”

Section: Differential Diagnosismentioning

confidence: 99%

Cytology of desmoplastic small round cell tumor

Crapanzano

Cardillo

Lin

et al. 2002

Cancer

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Section: Differential Diagnosismentioning

confidence: 99%

Cytology of desmoplastic small round cell tumor

Crapanzano

Cardillo

Lin

et al. 2002

Cancer

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“…The more common ones that can be counted as differentials in our case include peripheral neuroectodermal tumor, rhabdomyosarcoma, non-Hodgkin's lymphoma, neuroblastoma, nephroblastoma and desmoplastic small round cell tumour. 3 So the definitive diagnosis of most pediatric solid tumours requires extensive immunohistochemical markers because they often exhibit a nonspecific small round cell tumour phenotype. 4 …”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Bilateral Multifocal Breast Masses in a Child With Disseminated Rhabdomyosarcoma

Rehiman¹,

Jineesh²,

Rajendran³

et al. 2015

jemds

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Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence. Gross dissemination as multifocal solid masses to unusual sites such as breasts are rare, as we encountered in this case.In this report, we will be highlighting a rare case of disseminated rhabdomyosarcoma that presented as compressive thoracic myelopathy with bilateral multiple breast masses; which was diagnosed after radiological and histopathologic examination.

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“…Despite the frequency of neuroblastoma in children, to our knowledge the cytological criteria for diagnosis are poorly documented. 5,24,29 In these reports, FNA samples were described as hypercellular, and comprised of neuroblasts or differentiating cells with nuclear molding. Neuropil and rosettes were the most useful criteria for diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic information obtained on fine‐needle aspirates of primary neuroblastic tumors

Klijanienko

Couturier

Brisse

et al. 2011

Cancer Cytopathology

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BACKGROUND:The use of cytological material for diagnosis and prognosis in patients with neuroblastic tumors is poorly described in the literature. METHODS: A total of 129 patients with primary neuroblastic tumors underwent sampling with fine-needle aspiration for diagnosis and the evaluation of prognostic parameters. Of these, 125 (97%) were neuroblastomas or ganglioneuroblastomas and 4 (3%) were ganglioneuromas. Cellularity of the smears was assessed, as well as the percentage of neuroblasts versus stroma, maturation (differentiating/mature vs immature cells), the mitosis-karyorrhexis index (MKI), and the number of Homer Wright rosettes. The cytology samples were also analyzed for MYCN amplification, flow cytometric DNA index, and array comparative genomic hybridization. RESULTS: MYCN was found to be amplified in 35 (27%) cases. Strong correlations with overall survival were found for MYCN amplification in localized stages including IVs (P < .001), the percentage of neuroblasts versus stroma (P < .001), maturation (P ¼ .002), MKI (P < .001), and DNA index (P < .03). CONCLUSIONS: Poorly differentiated tumors with few stromal components and low numbers of differentiating/mature cells were found to be MYCN amplified. The authors propose a ''cytology prognostic score'' in which neuroblastomas comprised of predominantly neuroblastic elements with no differentiating cells and an MKI >; 2% are classified as high-risk tumors, regardless of their MYCN amplification status. The use of this proposed score would ensure accurate and optimal diagnostic and prognostic classifications of neuroblastic tumors in cases in which the histological biopsy is absent or inadequate for analysis. Cancer

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Fine-needle aspiration biopsy diagnosis of small round cell tumors of childhood: A comprehensive approach

Cited by 59 publications

References 58 publications

Cytology of desmoplastic small round cell tumor

Cytology of desmoplastic small round cell tumor

A Rare Case of Bilateral Multifocal Breast Masses in a Child With Disseminated Rhabdomyosarcoma

Diagnostic and prognostic information obtained on fine‐needle aspirates of primary neuroblastic tumors

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