Fine Needle Aspiration Biopsy in Central Giant Cell Lesion

Vargas, Pablo Agustı́n; Prado, Fabio Ornellas; Fregnani, Eduardo Rodrigues; Perez, Danyel Elias da Cruz; Lopes, Márcio Ajudarte; Moraes, Márcio de; Gerhard, Renê

doi:10.1159/000325991

Cited by 18 publications

(12 citation statements)

References 10 publications

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“…17,24,25 FNAC can be an important tool in the preoperative diagnosis of OKC, as this technique has a high rate of concordance with the histological diagnosis, 15 the latter being considered the gold standard in the definitive diagnosis of OKC. A variety of bone pathologies can present with a radiographic appearance similar to OKC and the differential diagnosis includes periapical and dentigerous cysts, ameloblastoma and giant cell lesion.…”

Section: Discussionmentioning

confidence: 99%

“…1 Cytokeratins (CKs) are a group of intermediate filaments mostly expressed by epithelial cells, which include a wide range of proteins, varying in molecular weight, acid/basic composition, and affinity. [11][12][13][14][15][16][17] Few studies have employed FNAC in the diagnosis of OKC. 8 Various reports describe the cytokeratin profile of the epithelia that line odontogenic cysts.…”

Section: Introductionmentioning

confidence: 99%

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Fine needle aspiration cytology as an additional tool in the diagnosis of odontogenic keratocyst

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fine needle aspiration cytology as an additional tool in the diagnosis of odontogenic keratocyst

et al. 2007

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“…Pain, trismus and swelling could not only suggest a malignant process but also a variety of infectious lesions and reactive processes (3,18,19). FNAC has been used for diagnosing tumors, infectious diseases and reactive disorders (20)(21)(22), and is frequently used as a helpful diagnostic tool in soft tissue masses located in the head and neck, and its use in salivary glands, oral cavity, lymph nodes, thyroid glands, as well as bone lesions in the jaws is well documented (20)(21)(22)(23)(24). Baden (25) and Persson and Domanski (26) made diagnosis of the tongue metastasis from uterus by FNAC.…”

Section: Discussionmentioning

confidence: 99%

Oral metastasis of uterine carcinoma: Case report and 83-year review of this uncommon occurrence

de¹,

H²,

Brum³

et al. 2012

Arch Oncol

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Uterine cervix cancer is the second most common female cancer and the third most common cause of female cancer mortality. The disease spreads into the surrounding tissues by direct infiltration, whereas, spread by hematogenous dissemination is relatively unusual and the involvement of oral and maxillofacial region is extremely rare in gynecological cancer. A 72-year-old Chinese woman was referred to our dental clinic with a 4-month history of a painful and gradually expanding swelling in oral cavity associated with a severe limitation of mouth opening. The submucosa was fibro-elastic with normal mucosal covering on the left side of the soft palate that extended up to the palatoglossal arch, measuring 2.5 cm in maximum diameter. Fine needle aspiration cytology was performed on the nodule and the cytological diagnosis was consistent with undifferentiated carcinoma. An incisional biopsy was performed and the diagnosis of undifferentiated carcinoma of primary unspecified location was made. The patient’s son reported that his mother had been experiencing the return of her “menstrual cycle” so we referred her to the gynecologist who detected a lesion in the cervix uteri, bigger than the one in the oral cavity. Both lesions had the same histological and immunohistochemical profile prompting us to report this case as carcinoma of the cervix uteri that metastasized to the oral cavity. Unfortunately, the patient died 24 months after the initial diagnosis of the oral metastasis. The patient received sessions of radiotherapy exclusively in both lesions. The review of literature showed that oral metastasis from uterine cervix carcinoma is rare, indicating poor prognosis and that the correlation of clinical medical history, laboratory, imagenological, cytological, histopathological and immunohistochemical exams are essential for achievement of the precise diagnosis

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“…Although the regular histopathological evaluation of this lesion does not pose difficulties for its correct diagnosis, the use of fine-needle aspiration cytology (FNAC) for the primary diagnosis of CGCG has been advocated, since this method has been proven safe and efficient, causing less injury to the patient, what is especially important for pediatric patients and cases of lesions located in esthetic regions (5)(6)(7). In addition, the conventional surgical management of CGCG usually causes major esthetic defects (2).…”

Section: Introductionmentioning

confidence: 99%

Fine Needle Aspiration Cytology and Intralesional Steroid Injection in a Central Giant Cell Granuloma Affecting the Gingiva: A New Clinical Approach

et al. 2013

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Central giant cell granuloma (CGCG) is a benign jaw lesion predominantly found in the mandible of young female patients with a variable clinical behavior. Although surgical management is regarded as the main treatment modality for this lesion, the use of intralesional injections of steroids has been recently advocated for its treatment. In addition to this conservative management, the use of fine needle aspiration cytology (FNAC) for diagnosing CGCGs has been proven a safe and efficient approach, especially useful in cases with lesions located in esthetic regions. Herein, it is described a case of CGCG extending to the overlying gingiva of a 15-year-old male patient diagnosed by FNAC and subsequently treated with intralesional injections of a solution of triamcinolone acetonide and ethanolamine oleate that led to an important clinical remission, allowing a more conservative surgical procedure for preservation of gingival esthetics. Therefore, both procedures can be considered as management options for CGCG of the jaws.

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Fine Needle Aspiration Biopsy in Central Giant Cell Lesion

Cited by 18 publications

References 10 publications

Fine needle aspiration cytology as an additional tool in the diagnosis of odontogenic keratocyst

Fine needle aspiration cytology as an additional tool in the diagnosis of odontogenic keratocyst

Oral metastasis of uterine carcinoma: Case report and 83-year review of this uncommon occurrence

Fine Needle Aspiration Cytology and Intralesional Steroid Injection in a Central Giant Cell Granuloma Affecting the Gingiva: A New Clinical Approach

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