Fine Needle Aspiration Biopsy of Primary Breast Myxofibrosarcoma

Klopčič, Ulrika; Lamovec, Janez; Luzar, Boštjan

doi:10.1159/000325095

Cited by 18 publications

(20 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7). Intranuclear inclusions are not specific to adenomyoepithelioma, but have been described in benign proliferative breast lesions [67], male breast carcinoma [68], myofibroblastoma [69] and myxofibrosarcoma [70]. Mild-to-moderate nuclear atypia is not uncommon and has led to FP diagnosis.…”

Section: Biphasic Tumorsmentioning

confidence: 99%

Indeterminate and Erroneous Fine-Needle Aspirates of Breast with Focus on the ‘True Gray Zone': A Review

2013

View full text Add to dashboard Cite

Objective: To review our experience and the literature on inconclusive/erroneous fine-needle aspirates (FNAs) of breast with the focus on the ‘true gray zone'. To describe the cytology, differential diagnosis, pitfalls and limitations of common and rare lesions. Study Design: We conducted a literature search focusing on breast FNAs with statistical data of C3 and C4 categories including false-positive and false-negative cases. Similar data from 2003 to 2009 was obtained from our institution. Results: C3 and C4 categories account for 3-17% of breast FNAs. Contributing factors are technical difficulties, inexperienced pathologists interpreting FNAs of breast and overlap of cytologic features of certain benign and malignant conditions; this last, ‘true gray zone' accounts for 2% of cases. Fibroadenoma, proliferative breast lesions, gynecomastia, infiltrating and in situ low-grade adenocarcinomas and tubular, cribriform, lobular and mucinous carcinomas are the most common problematic lesions. Granular cell tumor, adenomyoepithelioma, pregnancy-related lesions, fat necrosis, inflammatory and radiation changes, adenoid cystic carcinoma, spindle-cell lesions and Phyllodes tumor are less common. Conclusion: Inconclusive/erroneous FNAs of breast due to the ‘true gray zone' are rare. Most are due to the overlapping cytologic features of some benign and malignant conditions. Practical features that may help arrive at the correct diagnoses are elucidated.

show abstract

Section: Biphasic Tumorsmentioning

confidence: 99%

Indeterminate and Erroneous Fine-Needle Aspirates of Breast with Focus on the ‘True Gray Zone': A Review

2013

View full text Add to dashboard Cite

show abstract

“…Intranuclear inclusions are not specific to AMEs, but have been described in benign proliferative breast lesions, [20][21][22] male breast carcinoma, 23 myofibroblastoma, 24 and myxofibrosarcoma. 25 Intranuclear inclusions in benign proliferative epithelial breast lesions, whether intracytoplasmic invaginations or helioid bodies have been described in 50% of benign hyperplasias but not in atypical hyperplasias or ductal carcinomas in situ. Their presence in addition to other cytologic and architectural features may be used to arrive at the correct diagnosis.…”

Section: Biphasic Cell Population With Focal Nuclear Atypia and Intramentioning

confidence: 99%

Inconclusive or erroneous fine‐needle aspirates of breast with adequate and representative material: A cytologic/histologic study

Shabb

Boulos

Chakhachiro

et al. 2013

Diagnostic Cytopathology

View full text Add to dashboard Cite

Adequately cellular and representative fine-needle aspirates (FNAs) of breast have a high diagnostic accuracy. There is, however, a recognized category designated as "gray zone" where a definitive diagnosis cannot be reached. We reviewed our experience in this category to identify useful diagnostic parameters. Twenty-four such FNAs with surgical follow-up were retrieved from AUBMC files (2003-2009). Cytology slides were reviewed blindly. All cases were females, 29-73 years. There were three erroneous and 21 inconclusive diagnoses. The majority (15) was invasive adenocarcinomas: two cribriform, four tubular, one lobular, and eight not otherwise specified. The remaining cases were papillary and fibroepithelial tumors (three each), ductal carcinoma in situ, cribriform (two), and one adenomyoepithelioma (AME). Useful diagnostic features included: (1) Biphasic cell population with focal nuclear atypia and intranuclear and cytoplasmic vacuolar inclusions (AME). (2) Complex clusters of epithelial cells with cribriform architecture (cribriform carcinoma). (3) Rigid tubular epithelial structures with abrupt change in diameter, ending in pointed tips with abnormal branching (tubular carcinoma). (4) Cellular stromal fragments (fibroepithelial tumors). (5) Papillary fibrovascular cores, columnar cells, and three-dimensional papillary epithelial fragments (papillary tumors). Myoepithelial cells classically described in benign aspirates were not always a discriminatory factor. The "gray zone" in breast FNA is usually due to overlapping cytologic features of some benign and malignant lesions. Useful distinguishing cytologic features are described.

show abstract

“…Practically, however, the lesions reported in the breast with diffuse myxoid stromal changes are: superficial angiomyxoma [9], nodular mucinosis (first reported as nerve sheath myxoma) [16,17], nodular fasciitis (myxoid variant) [18], neurofibroma (myxoid variant) [19,20], myofibrolastoma (myxoid variant) [21,22], myxofibrosarcoma [23], myxoid liposarcoma [24], and mucocele-like tumors [15]. A list of these lesions, including their main clinico-pathological features, is provided in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Clinico-pathological features of breast myxoma: report of a case with histogenetic considerations

2010

View full text Add to dashboard Cite

We herein report the clinical, radiological, and pathological findings of a rare case of myxoma occurring in the breast parenchyma of a 75-year-old female. The tumor was incidentally detected at a mammographic screening and, ultrasonographically, presented as an ovoid mass. Histologically, an encapsulated hypocellular, myxoid tumor with low vascularization was evident. Neoplastic cells were round- to spindle/stellate-shaped and stained with vimentin and focally with calponin. We emphasize that morphology remains preeminent in the diagnosis of a breast myxoma, while immunohistochemistry may assist in ruling out other tumor entities. Differential diagnosis with all benign and malignant myxoid lesions, primarily occurring in the breast, is provided. The histogenesis of breast myxoma is unknown. The lack of expression of desmin, alpha-smooth muscle actin, CD34, CD99, CD10, bcl-2 protein, and estrogen/progesterone/androgen receptors, all markers characteristically expressed by "the benign spindle cell tumors of the mammary stroma," would suggest that breast myxoma does not fall into this tumor category and that its putative precursor mesenchymal cell resides in the interlobular stroma.

show abstract

Fine Needle Aspiration Biopsy of Primary Breast Myxofibrosarcoma

Cited by 18 publications

References 12 publications

Indeterminate and Erroneous Fine-Needle Aspirates of Breast with Focus on the ‘True Gray Zone': A Review

Indeterminate and Erroneous Fine-Needle Aspirates of Breast with Focus on the ‘True Gray Zone': A Review

Inconclusive or erroneous fine‐needle aspirates of breast with adequate and representative material: A cytologic/histologic study

Clinico-pathological features of breast myxoma: report of a case with histogenetic considerations

Contact Info

Product

Resources

About