Fine needle aspiration biopsy of pediatric head and neck masses

Liu, Edmund S.; Bernstein, Joseph; Sculerati, Nancy; Wu, Horace

doi:10.1016/s0165-5876(01)00522-5

Cited by 66 publications

(40 citation statements)

References 7 publications

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“…The utility of FNA biopsy in children has been illustrated in many studies. [5][6][7][8][9][10] As reported by Howell, the use of FNA for superficial palpable lesions is gaining momentum in the pediatric patient population. 6 To date, research detailing application of FNA to lesions of the head and neck in pediatric populations and the number of cases evaluated are limited.…”

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confidence: 94%

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Evaluation of fine needle aspiration biopsy as a diagnostic tool in pediatric head and neck lesions

Dutta¹,

Awasthi²,

Agarwal³

et al. 2010

PLMI

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Background: Fine needle aspiration (FNA) biopsy is a well accepted diagnostic procedure and considered to be a valuable test for initial assessment of head and neck swellings in adults. The technique has gained popularity in the pediatric population over the last decade, with varying degrees of acceptance rates, accuracy, and results among pathologists. Objective: This study was performed to evaluate the utility of aspiration cytology as a first-line diagnostic tool in palpable head and neck masses in children, taking into account the diversity of lesions observed in this subset of the population. Cytologic analysis was correlated with histologic results for evaluating diagnostic accuracy wherever possible. The applicability of FNA biopsy in diagnosing pediatric malignant lesions was also evaluated. Methods: This retrospective study conducted from January 2008 to December 2009 screened all pediatric cases referred to the departments of pathology at two tertiary care hospitals in India. Data from a total of 662 children aged 0-15 years presenting with head and neck masses who underwent FNA biopsy were collected. Cytologic results were interpreted and analyzed according to anatomic site. The lesions were then categorized into inflammatory, infective, and neoplastic. Results: Of the 662 lesions, 23 cases were excluded due to inadequate material, thus the data for 639 cases were finally evaluated. Lymph node lesions predominated, accounting for 570 cases (89.2%), of which 412 (72%) cases were diagnosed as reactive and 91 (16%) cases as tubercular lymphadenitis. Other lesions aspirated were thyroid (18 cases, 2.8%), salivary gland (12 cases, 1.8%), and miscellaneous surface lumps (39 cases, 6.1%). Of all the cases, 628 (98.27%) were reported as benign and 11 (1.67%) as malignant. The positive predictive value of cytologic analysis in diagnosing malignancy was 100%, although exact typing of lesions was possible only on histopathologic examination. Conclusion: FNA biopsy is a sensitive and minimally invasive first-line investigation in the diagnosis of head and neck masses in children. It is highly accurate in isolating and determining potentially neoplastic lesions, thus guiding the way for cases which truly require excision biopsy or other second-line investigations.

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confidence: 94%

“…Moreover, some studies have limited their focus to features of malignant lesions, such as small round cell neoplasms or salivary gland lesions. [8][9][10] The range of lesions which can be reliably diagnosed by this method is rapidly expanding. Lack of need for sedation or general anesthesia is an additional benefit in the pediatric patient.…”

mentioning

confidence: 99%

Evaluation of fine needle aspiration biopsy as a diagnostic tool in pediatric head and neck lesions

Dutta¹,

Awasthi²,

Agarwal³

et al. 2010

PLMI

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“…4,5,7,9 In our study, we showed that ultrasound guidance increased the adequacy (diagnostic yield), sensitivity, and accuracy of neck mass FNC to 94%, 97%, and 96%, respectively. Most strikingly, the accuracy of diagnosing malignant neck masses reached 98% in our study, with a positive predictive value of 98% in 48 malignant cancers, including metastases (P = .023).…”

Section: Discussionmentioning

confidence: 49%

“…3 Therefore, a proper and minimally invasive means of diagnosing a neck mass is crucial for effective treatment planning. Two fine-needle biopsy (FNB) techniques have been widely used in clinical settings with promising diagnostic benefit as outpatient procedures [4][5][6][7] : fine-needle aspiration biopsy (FNA) and fine-needle capillary sampling biopsy (FNC). Of these, FNC, also known as the French biopsy technique, is a type of FNB technique that involves repetitive passes of a 25-gauge needle through the neck mass.…”

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confidence: 99%

How Diagnostic Is Ultrasound-Guided Neck Mass Biopsy (Fine-Needle Capillary Sampling Biopsy Technique)?

Lee

Chen

Sauk

et al. 2009

Journal of Ultrasound in Medicine

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Objective. The purpose of this study was to evaluate the diagnostic value of ultrasound-guided neck mass biopsy (fine-needle capillary sampling biopsy [FNC] The most biopsied location was in the lymph nodes (34.8%), followed by perithyroid soft tissue masses (28.0%). A 25-gauge needle was used most frequently (97.7%). A total of 41 biopsies were diagnostic for thyroid diseases (31.1%), with the most common being thyroid papillary carcinoma. We found metastases in 31 biopsies (23.5%). Following these 2 were 29 lymph node biopsies. No major complications were noted. Of the 132 neck masses biopsied, 8 were pathologically nondiagnostic (93.9% diagnostic yield), yielding sensitivity, specificity, and accuracy of greater than 95% (97.1%, 95.2%, and 95.8%, respectively). Conclusions. Ultrasound-guided FNC of neck masses is highly diagnostic. The diagnostic yield is especially high for detection of malignancy, including metastases. Together with a high clinical suspicion, ultrasound-guided needle biopsy should be performed to form a correct diagnosis and make appropriate management plans.

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“…The final diagnosis is established through pathological examination after excision, but fine needle aspiration biopsy (FNAB) from the mass can be performed for pre-diagnosis (6). In the studies conducted in USA over the past 20 years, it has been reported that the results of FNAB in pediatric cases are as correct as those in adult patients and FNAB protects patient from negative outcomes such as general anesthesia, pain, scar, wound infection, and delayed diagnosis (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Pediatric Mass Lesions of the Head and Neck Region and Fine-Needle Aspiration Biopsy Results

Eskı¹,

Akdoğan²,

Türkoğlu³

et al. 2016

Turk Arch Otorhinolaryngol

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Objective: 1. To provide a classification of pediatric mass of the head and neck region and evaluate their frequency. 2. To examine the findings of fine-needle aspiration biopsy (FNAB) in pediatric patients along with its contribution to diagnosis. Methods:Totally, 233 pediatric patients (125 boys and 108 girls) operated at Başkent University for head and neck mass were included. Clinical, radiological, and histopathological data were retrieved from medical records. Results:The mean age was 119±65 months, and the mean duration of follow-up was 75±49 months. Localization of the masses was as follows: 208 (89%) in the neck, 21 (9%) in the oral cavity, 2 (1%) in the neck and nasopharynx, and two (1%) in the larynx. The most common surgical procedure was open excisional biopsy (n=105, 45%) followed by cystic mass excision (n=72, 31%) and salivary gland excision (n=33, 14%). Based on histopathological findings, benign cystic lesions were the most common disease group (n=77, 33.1%), whereas reactive lymphadenopathy was the most common condition (n=36, 15%) when a single disease was considered. Infectious/inflammatory diseases, malignancies, and benign salivary gland diseases were present in 49 (21%), 24 (10.3%), and 22 (9.4%) patients, respectively. FNAB was performed in 29.8% of the patients with an accuracy of 90.3% (95% CI, 80.1-96.4). Conclusion:The differential diagnosis of head and neck masses during childhood includes a wide spectrum with the different conditions being benign cystic diseases of congenital origin and reactive lymphadenopathies. Owing to its high predictive value, FNAB represents a rapid and reliable method that can be commonly used in both adult and pediatric patients.

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Fine needle aspiration biopsy of pediatric head and neck masses

Cited by 66 publications

References 7 publications

Evaluation of fine needle aspiration biopsy as a diagnostic tool in pediatric head and neck lesions

Evaluation of fine needle aspiration biopsy as a diagnostic tool in pediatric head and neck lesions

How Diagnostic Is Ultrasound-Guided Neck Mass Biopsy (Fine-Needle Capillary Sampling Biopsy Technique)?

Pediatric Mass Lesions of the Head and Neck Region and Fine-Needle Aspiration Biopsy Results

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