Fine‐needle aspiration biopsy of seminoma and dysgerminoma: Cytologic, histologic, and electron microscopic correlations

Akhtar, Mohammed; Ma, Ali; M, Huq; Bakry, Mohammed

doi:10.1002/dc.2840060206

Cited by 28 publications

(10 citation statements)

References 15 publications

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“…37 The germ cell tumors were also common in this study. The cells from dysgerminoma resembled closely the type 111 cells described by Akhtar et al 38 One of our teratomas was from mediastinum which was a rare neoplasm to be diagnosed preoperatively by FNA cytology. 39 Inflammatory lesions constituted a significant proportion of our cases.…”

Section: Discussionmentioning

confidence: 65%

Fine‐needle aspiration diagnosis of intra‐thoracic and intra‐abdominal lesions: Review of experience in the pediatric age group

Das

Pant

Rath

et al. 1993

Diagnostic Cytopathology

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Review of fine-needle aspiration (FNA) smears from 121 pediatric patients with intra-thoracic and intra-abdominal lesions revealed 42 (34.7%) cases of neoplasms, 35 (28.9%) cases of tuberculosis, 12 (9.9%) cases of non-tuberculous inflammations, 4 (3.3%) cases of benign cystic lesions, and 28 (23.1%) inadequate/inconclusive cases. The age of the patients ranged from 20 days to 18 yr. Ultrasound and/or CT study done in 105 cases localized the lesions in following common sites: lungs (19 cases), mediastinum (22 cases), liver (14 cases), intestines (11 cases), and lymph nodes (17 cases). The neoplastic lesions consisted of 39 malignant, one suspicious, and two benign neoplasms. Among the neoplasms, the small round cell tumors were the most frequent (27 cases), followed by germ cell tumors (eight cases) and miscellaneous neoplasms (seven cases). The common small round cell tumors were non-Hodgkins lymphoma (eight cases), hepatoblastoma (seven cases), neuroblastoma (five cases), and nephroblastoma (three cases). A combined clinical, imaging, and FNA cytology approach was found to be useful in arriving at a tissue diagnosis.

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Section: Discussionmentioning

confidence: 65%

Fine‐needle aspiration diagnosis of intra‐thoracic and intra‐abdominal lesions: Review of experience in the pediatric age group

Das

Pant

Rath

et al. 1993

Diagnostic Cytopathology

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“…The cytological features of mediastinal and gonadal seminomas are similar and well illustrated in the Papanicolaou‐stained smears of this case . Granulomas and giant cells, observed in variable numbers in some of these tumors, were not found in the smears or tissue sections prepared from this tumor.…”

Section: Discussionmentioning

confidence: 63%

Mediastinal seminoma: A case report with special emphasis on SALL4 as a new immunocytochemical marker

Iwamoto

Ishida

Yoshida

et al. 2012

Diagnostic Cytopathology

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Cytological diagnosis is a valuable method for detection of mediastinal tumors, and recent reports have shown the usefulness of fine-needle aspiration cytology for diagnosis of mediastinal tumors, including germ cell tumors. We report a case of mediastinal seminoma diagnosed intraoperatively by cytological examination of cystic fluid containing tumor cells. An anterior mediastinal tumor with cystic component was incidentally found in a 28-year-old Japanese male. Cytological examination of the cystic fluid at the time of tumor resection showed single and loose aggregates of large round to polygonal cells with large round nuclei, vesicular chromatin and nucleoli, and mild to moderate amounts of PAS-positive cytoplasm admixed with mature lymphocytes. A diagnosis of seminoma was made intraoperatively. On subsequent immunostaining, the tumor cells showed nuclear positivity for SALL4, a recently recognized germ cell marker that, in the appropriate setting, can be helpful to distinguish germ cell tumors from other mediastinal neoplasms, such as malignant lymphoma, thymoma, and thymic carcinoma.

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“…The tumor cells have round nuclei with a fine chromatin pattern and well-developed, usually single nucleoli. 4,5,11,[13][14][15][16][17][18] The amount and character of cytoplasm are quite variable. Most of the cells have moderate-to-abundant cytoplasm, which contains a few small, round lipid vacuoles.…”

Section: Seminoma/dysgerminomamentioning

confidence: 99%

Is it feasible to diagnose germ-cell tumors by fine-needle aspiration biopsy?

Akhtar

Dayel

1997

Diagn. Cytopathol.

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Fine needle aspiration biopsy is an extremely useful procedure for the diagnosis of germ cell tumors. Most of the subtypes can be easily recognized and differentiated from other subtypes. For difficult cases clinical pathologic correlation may be extremely helpful in establishing a precise diagnosis. Mixed germ cell tumors may cause some difficulty if one of the components is predominant. Immunohistochemistry may also play an important role in arriving at a definitive diagnosis. Diagn. Cytopathol. 16:72–77, 1997. © 1997 Wiley‐Liss, Inc.

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Fine‐needle aspiration biopsy of seminoma and dysgerminoma: Cytologic, histologic, and electron microscopic correlations

Cited by 28 publications

References 15 publications

Fine‐needle aspiration diagnosis of intra‐thoracic and intra‐abdominal lesions: Review of experience in the pediatric age group

Fine‐needle aspiration diagnosis of intra‐thoracic and intra‐abdominal lesions: Review of experience in the pediatric age group

Mediastinal seminoma: A case report with special emphasis on SALL4 as a new immunocytochemical marker

Is it feasible to diagnose germ-cell tumors by fine-needle aspiration biopsy?

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