Fine Needle Aspiration Cytodiagnosis of Leiomyosarcoma of the Breast

Gupta, Raj K.; Kenwright, Diane; Naran, Sarla; Lallu, Sharda; Fauck, Robert

doi:10.1159/000328606

Cited by 20 publications

(14 citation statements)

References 25 publications

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“…Most reported cases of LMS of the breast have occurred in middleaged women 1,2,5,6 ; however, at least 2 reports 3,4 suggest that LMS may be more common in the male breast than is apparent. Bhagat and Kline 3 found 1 of 14 and Mondal and Mukherjee 4 found 2 of 12 malignant male breast neoplasms to be LMS.…”

Section: Discussionmentioning

confidence: 99%

“…FNA cytologic diagnosis of breast sarcomas is a challenging task, 2,5,6 and LMS of the breast has been mistaken cytologically for poorly differentiated carcinoma 6 and medullary carcinoma. 1 Tumors containing osteoclastlike giant cells have been mistaken for MC, and the diagnosis of malignant PT has been made on the assumption that the epithelial element may not be represented in the cytologic material.…”

Section: Discussionmentioning

confidence: 99%

“…6 A Bhagat-Kline 3 case, as well as ours, showed a polymorphous population of spindle, plump, polygonal and histiocytoid cells with vacuolated cytoplasm resembling MFH. Unlike Gupta et al, 2 we lacked cytologic material for the panel of immunostains that is mandatory for a conclusive cytologic diagnosis of LMS.…”

Section: Discussionmentioning

confidence: 99%

“…16 LMS of the breast may arise from muscular blood vessels or from smooth muscle around the nipple. 2,17 Tumors that are positive for SMA but not desmin may have their origin in myofibroblasts. 2 Once metastatic LMS has been excluded, treatment in these patients consists of wide excision or mastectomy.…”

Section: Discussionmentioning

confidence: 99%

“…2,17 Tumors that are positive for SMA but not desmin may have their origin in myofibroblasts. 2 Once metastatic LMS has been excluded, treatment in these patients consists of wide excision or mastectomy. 18 Axillary clearance, done in our case due to the differential diagnostic possibility of metaplastic carcinoma, can be avoided by combining IC with FNA cytology when …”

Section: Discussionmentioning

confidence: 99%

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Leiomyosarcoma of the Breast

Jayaram

Pailoor²,

Yip³

2005

Acta Cytologica

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Leiomyosarcoma of the Breast

Jayaram

Pailoor²,

Yip³

2005

Acta Cytologica

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Fine‐needle aspiration of leiomyosarcoma: A correlative cytohistopathological study of 96 tumors in 68 patients

Klijanienko

Caillaud²,

Lagacé

et al. 2003

Diagnostic Cytopathology

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To better define the cytological features of various leiomyosarcoma (LMS) variants, we reviewed the fine-needle aspiration material and the corresponding histologic sections of 96 tumors in 68 patients. Histological variants of LMS were as follows: 80 (83.3%) were of the classical/usual, seven (7.3%) were epithelioid, and nine (9.4%) were myxoid. Review of original cytology reports showed that 23 (24%) tumors were diagnosed as LMS and 69 (71.8%) as other types of malignancies. Two (2.1%) cases were reported as suspicious and two (2.1%) were unsatisfactory. The classical variants of LMS were characterized cytologically by various proportions of spindle-shaped, cohesive, small- or large-sized cells arranged in parallel alignment. Large spindle, round, binucleated, giant cells with intracytoplasmic granulations were frequently seen. Blunt-ended nuclei, intranuclear inclusions and mitotic figures were occasionally seen, as well as stromal fragments. The epithelioid tumors were composed of an admixture of small and large, spindle-shaped and round cells, also arranged in parallel alignment. Tumor cells with granular cytoplasm, blunt-ended nuclei, intranuclear inclusions, mitotic figures, fibrous or myxoid stroma were not observed. The myxoid tumors disclosed large amounts of background myxoid matrix containing large spindle-shaped and giant cells. Entities such as leiomyoma, malignant peripheral nerve sheath tumor, monophasic synovial sarcoma, and malignant fibrous histiocytoma should be considered in the differential diagnosis of LMS of the classical type. Epithelioid leiomyoma may share similar cytological features with epithelioid LMS. The cytological features of the myxoid variant of LMS can be easily confused with other types of benign and malignant mesenchymal tumors depicting degenerative myxoid changes and/or a myxoid matrix component.

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Leiomyosarcoma of the breast: A difficult diagnosis on fine‐needle aspiration biopsy

Wei

Hiotis

Garcı́a

et al. 2003

Diagnostic Cytopathology

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Leiomyosarcoma of the breast is rarely encountered in fine-needle aspiration (FNA) cytologic material. We report a case of primary leiomyosarcoma of the breast in a 52-yr-old female. Aspiration cytology showed large, dissociated round to spindle cells with abundant vacuolated cytoplasm, pleomorphic nuclei, prominent nucleoli, and occasional intranuclear cytoplasmic invaginations. Mitotic figures, osteoclast-like giant cells, and stromal fragments were identified. A diagnosis of malignant neoplasm representing either a sarcoma, a poorly differentiated carcinoma, or a metaplastic carcinoma was made. The patient underwent a wide excision of the lesion after negative work-up. Histologic examination and immunohistochemical studies established the diagnosis of leiomyosarcoma. This case is presented here because we feel that, although FNA cytology with eventual ancillary studies is a valuable diagnostic tool to evaluate any breast mass, malignant spindle cell neoplasms of the breast still represent a diagnostic challenge for the cytopathologist. Recognition of all cytologic features of leiomyosarcoma may help to formulate a correct diagnosis.

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Fine Needle Aspiration Cytodiagnosis of Leiomyosarcoma of the Breast

Cited by 20 publications

References 25 publications

Leiomyosarcoma of the Breast

Leiomyosarcoma of the Breast

Fine‐needle aspiration of leiomyosarcoma: A correlative cytohistopathological study of 96 tumors in 68 patients

Leiomyosarcoma of the breast: A difficult diagnosis on fine‐needle aspiration biopsy

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