Fine Needle Aspiration Cytology of Mammary Carcinoma with Choriocarcinomatous Features

Akbulut, Metin; Zekioğlu, Osman; Özdemir, Necmettin; Kapkaç, Murat

doi:10.1159/000325443

Cited by 10 publications

(12 citation statements)

References 18 publications

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“…In the literature, a right breast predilection was reported. However, in our case the tumour was located in the left breast 12,14 . In two cases, only positivity for ER and/or PR staining were reported, although these were negative in our case 7,15 .…”

Section: Resultscontrasting

confidence: 49%

Breast Carcinoma with Choriocarcinomatous Differentiation; a Rare Case

Oğuz

Dizdar

Altundağ

et al. 2014

European Journal of Case Reports in Internal Medicine

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Objectives: Breast carcinoma with choriocarcinomatous differentiation is a rare entity, generally presenting with high--grade disease and an aggressive clinical course with overall survival of less than a yearCase: A 69--year--old woman with a diagnosis of pT1N0M0 invasive ductal carcinoma with choriocarcinomatous differentiation received six cycles of adjuvant chemotherapy and is still disease free on the 23rd month after diagnosis, showing a better prognosis than most other cases reported in the literature. Conclusion:The reason for the poor prognosis for this type of breast carcinoma remains unclear.Standard chemotherapeutic agents administered for breast carcinoma may be used for choriocarcinomatous differentiation.

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Section: Resultscontrasting

confidence: 49%

Breast Carcinoma with Choriocarcinomatous Differentiation; a Rare Case

Oğuz

Dizdar

Altundağ

et al. 2014

European Journal of Case Reports in Internal Medicine

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“…Surgery is generally considered to be effective in treating BCCF. Although there are BCCF patients who presented with multiple metastases and a short survival period after surgery [7,10], the BCCF patients who had a disease-free survival period of more than 1 year all underwent surgical resection [3,8,9,14]. The two patients reported by Erhan et al who were disease-free 2 and 4 years after diagnosis also underwent surgical resection [3].…”

Section: Discussionmentioning

confidence: 99%

Breast carcinoma with choriocarcinomatous features: a case report and review of the literature

Zhu

Liu

et al. 2014

World J Surg Onc

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BackgroundBreast carcinoma with choriocarcinomatous features (BCCF) is a rare variant of breast cancer, characterized by high expression of human chorionic gonadotropin (HCG) in cancer cells such as multinucleated syncytiotrophoblast-like giant cells. The first case of BCCF was reported in 1981 by Saigo and Rosen. Only one case of BCCF was reported to show no component of breast ductal carcinoma, and only partially cancer cells, such as multinucleated syncytiotrophoblast-like giant cells, expressed HCG in all previous BCCF cases. Here, we report the first BCCF case without any component of breast ductal carcinoma in which HCG was found to express in all cancer cells.Case presentationA 32-year-old female patient presented with a small lump in her left breast 3 years prior. The mass was clinically suspected to be breast infiltrating ductal carcinoma based on breast excisional biopsy and magnetic resonance imaging findings. Due to rupture and bleeding of the left kidney, the left kidney excisional biopsy was performed. After a retrospective analysis of the initial excised breast cancer and breast cancer metastatic to the kidney, the cancer cells were positive for HCG by immunohistochemistry, and multinucleated or mononucleated giant cells resembled syncytiotrophoblastic and cytotrophoblastic cells which could be seen in a background of poor differentiated breast carcinoma and extensive necrosis and hemorrhage in the lesion. Thus, a final diagnosis of BCCF and BCCF metastatic to the kidney was made. After combination of surgical resection (the affected left breast and left kidney wereremoved) and consecutive chemotherapy consisting of docetaxel, epirubicin, cisplatin, lobaplatin, and capecitabine, the patient achieved favorable therapeutic efficacy (the HCG level returned to normal values, the metastatic lesions in the lungs disappeared, and the survival was 37 months). Capecitabine was very efficient and highly recommended due to its superior efficacy in reducing the HCG level and eliminating the metastatic lesions in the lungs.ConclusionsThis is the first report of a rare case of BCCF without any component of breast ductal carcinoma, featured by high expression of HCG in all cancer cells. Combination of surgery and chemotherapy (especially capecitabine) achieved a favorable therapeutic efficacy.

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“…This was an unusual case report of a breast carcinoma in a 55-year-old woman. Grossly, the 2.5-cm tumor was partially hemorrhagic and consisted of areas of invasive ductal carcinoma admixed with areas very similar to choriocarcinoma [7]. …”

Section: Discussionmentioning

confidence: 99%

Breast Carcinoma with Choriocarcinomatous Features: A Case Report

et al. 2013

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Nongestational choriocarcinoma differentiation is extremely rare in breast neoplasms. It is characterized by tumor cells similar to chorionic trophoblastic cells, which react with human placental lactogen and human chorionic gonadotropin (hCG). A 56-year-old woman presented with a palpable right breast mass without past history of trophoblastic tumors. An F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scan revealed one focus with low accumulation of FDG in the right breast (maximum standardized uptake value, 1.98). The patient underwent a right mastectomy and biopsy of sentinel nodes. Microscopically, the tumor was a typical invasive ductal carcinoma with multiple foci of choriocarcinoma features. Immunohistochemistry showed that the tumor cells resembling choriocarcinoma were positive for hCG antibody, but negative for HER2/neu, estrogen receptor, and progesterone receptor. A pathologic diagnosis of breast carcinoma with choriocarcinomatous features was made. To our knowledge, this is the first report of invasive carcinoma with choriocarcinomatous features and an unusual finding of low accumulation in an F-18 FDG PET/CT scan in Korea.

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Fine Needle Aspiration Cytology of Mammary Carcinoma with Choriocarcinomatous Features

Cited by 10 publications

References 18 publications

Breast Carcinoma with Choriocarcinomatous Differentiation; a Rare Case

Breast Carcinoma with Choriocarcinomatous Differentiation; a Rare Case

Breast carcinoma with choriocarcinomatous features: a case report and review of the literature

Breast Carcinoma with Choriocarcinomatous Features: A Case Report

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