Fine Needle Aspiration Cytology of Metastatic Olfactory Neuroblastoma

Fine Needle Aspiration Cytology of Metastatic Olfactory Neuroblastoma

“…3 Although not all authors described a fibrillary character to the cytoplasm, many did note a cytoplasmic network. 1,4 Single cells with elongated cytoplasm, described by Jobst et al, 5 were not a frequent finding and were less helpful for diagnosis in our case. Nuclear molding was variably noted.…”

“…Previous case reports that describe the cytologic findings of ONB strongly support our diagnosis. 1,[3][4][5][6]8 In general, the cytologic features of ONB mimic those of conventional neuroblastoma. [9][10][11][12][13] Overall, authors found single cells and cell groups with a variable number of rosettes or pseudorosettes.…”

“…While some suggestion of nuclear molding within small cell groups was present in our air-dried smears, on alcohol-fixed, H&E-stained slides there was nuclear overlapping in the cell groups rather than nuclear molding. Fagan 8 found nuclear molding infrequently, while Jobst and Collins 1,5 described it as occurring more commonly.…”

“…This tumor may occur at any age but is most common in adults. [1][2][3][4][5][6] It is slightly more frequent in females. 2 There is no racial predilection.…”

“…3 The cytomorphologic findings of metastatic ONB involving cervical lymph nodes were described in only two recent papers. 1,4 In this case report, we describe the cytologic findings of ONB metastatic to a cervical lymph node; it was successfully diagnosed by FNA and the cytologic features compared with the histologic features.…”